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Mouse (Murine) Monoclonal UNC13A Primary Antibody for IP, ELISA - ABIN1742276
Martín, Durroux, Ciruela, Torres, Pin, Sánchez-Prieto: The metabotropic glutamate receptor mGlu7 activates phospholipase C, translocates munc-13-1 protein, and potentiates glutamate release at cerebrocortical nerve terminals. in The Journal of biological chemistry 2010
Show all 6 Pubmed References
Human Polyclonal UNC13A Primary Antibody for ICC, IP - ABIN1742277
Rinetti, Schweizer: Ubiquitination acutely regulates presynaptic neurotransmitter release in mammalian neurons. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Show all 3 Pubmed References
This study demonstrated that the population specific rare variants of UNC13A may modulate survival in ALS in United kingdom.
Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder
UNC13A rs12608932 is a risk factor for ALS and a modifying factor for survival and disease progression rate in a Spanish cohort.
Munc13-1, on account of its role in both insulin (show INS Antibodies) and neurotransmitter exocytosis and through its binding properties, may be an important factor contributing to the development or progression of diabetic neuropathy.
UNC13A provides a novel link between amyotrophic lateral sclerosis and frontotemporal dementia and identifies changes in neurotransmitter release and synaptic function as a converging mechanism in the pathogenesis of ALS (show IGFALS Antibodies) and FTD (show FTL Antibodies)-TDP.
CAPS1 (show CAPS Antibodies) binds to the full-length of cytoplasmic syntaxin-1 (show STX1A Antibodies) with preference to its "open" conformation, whereas Munc13-1 binds to the first 80 N-terminal residues of syntaxin-1 (show STX1A Antibodies).
This study demonistrated that UNC13A influences survival in Italian amyotrophic lateral sclerosis patients.
Our results further corroborate the role of UNC13A in amyotrophic lateral sclerosis pathogenesis.
Here, we report that, like Rab3A (show RAB3A Antibodies), RIM (show RBBP8 Antibodies) and Munc13 (show UNC13B Antibodies) are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux
Results do not provide evidence of an association between a variant in the UNC13A gene and susceptibility to sporadic Amyotrophic lateral sclerosis in a French homogeneous population.
SIGNIFICANCE STATEMENT: DBA (show RPS19 Antibodies)/2J and C57BL/6J mice have been used to understand the genetic mechanisms controlling behaviors related to a number of psychiatric illnesses. However, the fundamental neurobiological mechanisms producing these behavioral characteristics remain unresolved. Here we identify a critical family of presynaptic proteins differentially expressed by these strains that control strain-dependent synaptic ph
Munc13-2 (show UNC13B Antibodies) is recruited to synapses by the AZ protein ELKS1.
Munc13-2 (show UNC13B Antibodies) plays a fundamental role in large dense-core vesicle exocytosis, but in contrast to synapses lacking Munc13s, the corresponding chromaffin cells do not exhibit a vesicle docking defect.
Data demonstrate that Munc13-1 and DOC2B (show DOC2B Antibodies) have different effects on network activity and that by enhancing asynchronous release, DOC2B (show DOC2B Antibodies) exerts its properties to increase spiking activity and elevate synchronization between neurons within network bursts
Munc13-1 isoform is functionaly redundant in cytotoxic T lymphocytes.
betaARs couple to a cAMP/Epac (show RAPGEF3 Antibodies)/PLC (show HSPG2 Antibodies)/Munc13-1/Rab3a (show RAB3A Antibodies)/RIM1a (show RIMS1 Antibodies)-dependent pathway to enhance glutamate (show GRIN1 Antibodies) release at cerebrocortical nerve terminals.
Our data establish Munc13-1 as a major presynaptic target of Ca(2 (show CA2 Antibodies)+)-Calmodulin signaling and show that the Ca(2 (show CA2 Antibodies)+)-Calmodulin-Munc13-1 complex is a pivotal component of the molecular machinery that determines short-term synaptic plasticity characteristics.
The Munc13 (show UNC13B Antibodies) gene family encodes molecules located at the synaptic active zone that regulate the reliability of synapses to encode information over a wide range of frequencies in response to action potentials.
This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis.
protein unc-13 homolog A
, UNC-13 homolog 1
, protein unc-13 homolog B
, unc-13 homolog A
, unc13 homolog 1