Browse our anti-Unc-13 Homolog A (C. Elegans) (UNC13A) Antibodies

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anti-Unc-13 Homolog A (C. Elegans) Antibodies (UNC13A)
On www.antibodies-online.com are 11 Unc-13 Homolog A (C. Elegans) (UNC13A) Antibodies from 7 different suppliers available. A total of 11 Unc-13 Homolog A (C. Elegans) products are currently listed.
Synonyms:
2410078G03Rik, Munc13-1, Munc13-2, Unc13a, Unc13h1, Unc13h2
list all antibodies Gene Name GeneID UniProt
UNC13A 23025 Q9UPW8
UNC13A 382018 Q4KUS2
UNC13A 64829 Q62768

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Top referenced anti-Unc-13 Homolog A (C. Elegans) Antibodies

  1. Mouse (Murine) Monoclonal UNC13A Primary Antibody for IP, ELISA - ABIN1742276 : Martín, Durroux, Ciruela, Torres, Pin, Sánchez-Prieto: The metabotropic glutamate receptor mGlu7 activates phospholipase C, translocates munc-13-1 protein, and potentiates glutamate release at cerebrocortical nerve terminals. in The Journal of biological chemistry 2010 (PubMed)
    Show all 6 references for 1742276

  2. Human Polyclonal UNC13A Primary Antibody for ICC, IP - ABIN1742277 : Rinetti, Schweizer: Ubiquitination acutely regulates presynaptic neurotransmitter release in mammalian neurons. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 (PubMed)
    Show all 3 references for 1742277

More Antibodies against Unc-13 Homolog A (C. Elegans) Interaction Partners

Human Unc-13 Homolog A (C. Elegans) (UNC13A) interaction partners

  1. Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder

  2. UNC13A rs12608932 is a risk factor for ALS and a modifying factor for survival and disease progression rate in a Spanish cohort.

  3. Munc13-1, on account of its role in both insulin (show INS Antibodies) and neurotransmitter exocytosis and through its binding properties, may be an important factor contributing to the development or progression of diabetic neuropathy.

  4. UNC13A provides a novel link between amyotrophic lateral sclerosis and frontotemporal dementia and identifies changes in neurotransmitter release and synaptic function as a converging mechanism in the pathogenesis of ALS (show IGFALS Antibodies) and FTD (show FTL Antibodies)-TDP.

  5. CAPS1 (show CAPS Antibodies) binds to the full-length of cytoplasmic syntaxin-1 (show STX1A Antibodies) with preference to its "open" conformation, whereas Munc13-1 binds to the first 80 N-terminal residues of syntaxin-1 (show STX1A Antibodies).

  6. This study demonistrated that UNC13A influences survival in Italian amyotrophic lateral sclerosis patients.

  7. Our results further corroborate the role of UNC13A in amyotrophic lateral sclerosis pathogenesis.

  8. Here, we report that, like Rab3A (show RAB3A Antibodies), RIM (show RBBP8 Antibodies) and Munc13 (show UNC13B Antibodies) are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux

  9. Results do not provide evidence of an association between a variant in the UNC13A gene and susceptibility to sporadic Amyotrophic lateral sclerosis in a French homogeneous population.

  10. rs12608932 Single Nucleotide Polymorphism is located at 19p13.3 and maps to a haplotype block within the boundaries of UNC13A, which regulates the release of neurotransmitters such as glutamate (show GRIN1 Antibodies) at neuromuscular synapses.

Mouse (Murine) Unc-13 Homolog A (C. Elegans) (UNC13A) interaction partners

  1. Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder

  2. SIGNIFICANCE STATEMENT: DBA (show RPS19 Antibodies)/2J and C57BL/6J mice have been used to understand the genetic mechanisms controlling behaviors related to a number of psychiatric illnesses. However, the fundamental neurobiological mechanisms producing these behavioral characteristics remain unresolved. Here we identify a critical family of presynaptic proteins differentially expressed by these strains that control strain-dependent synaptic ph

  3. Munc13-2 (show UNC13B Antibodies) is recruited to synapses by the AZ protein ELKS1.

  4. Munc13-2 (show UNC13B Antibodies) plays a fundamental role in large dense-core vesicle exocytosis, but in contrast to synapses lacking Munc13s, the corresponding chromaffin cells do not exhibit a vesicle docking defect.

  5. Data demonstrate that Munc13-1 and DOC2B (show DOC2B Antibodies) have different effects on network activity and that by enhancing asynchronous release, DOC2B (show DOC2B Antibodies) exerts its properties to increase spiking activity and elevate synchronization between neurons within network bursts

  6. Munc13-1 isoform is functionaly redundant in cytotoxic T lymphocytes.

  7. betaARs couple to a cAMP/Epac (show RAPGEF3 Antibodies)/PLC (show HSPG2 Antibodies)/Munc13-1/Rab3a (show RAB3A Antibodies)/RIM1a (show RIMS1 Antibodies)-dependent pathway to enhance glutamate (show GRIN1 Antibodies) release at cerebrocortical nerve terminals.

  8. CAPS1 (show CAPS Antibodies) binds to the full-length of cytoplasmic syntaxin-1 (show STX1A Antibodies) with preference to its "open" conformation, whereas Munc13-1 binds to the first 80 N-terminal residues of syntaxin-1 (show STX1A Antibodies).

  9. Our data establish Munc13-1 as a major presynaptic target of Ca(2 (show CA2 Antibodies)+)-Calmodulin signaling and show that the Ca(2 (show CA2 Antibodies)+)-Calmodulin-Munc13-1 complex is a pivotal component of the molecular machinery that determines short-term synaptic plasticity characteristics.

  10. The Munc13 (show UNC13B Antibodies) gene family encodes molecules located at the synaptic active zone that regulate the reliability of synapses to encode information over a wide range of frequencies in response to action potentials.

Unc-13 Homolog A (C. Elegans) (UNC13A) Antigen Profile

Antigen Summary

This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis.

Alternative names and synonyms associated with Unc-13 Homolog A (C. Elegans) (UNC13A)

  • unc-13 homolog A (C. elegans) (UNC13A) antibody
  • unc-13 homolog A (C. elegans) (Unc13a) antibody
  • unc-13 homolog B (C. elegans) (Unc13b) antibody
  • 2410078G03Rik antibody
  • Munc13-1 antibody
  • Munc13-2 antibody
  • Unc13a antibody
  • Unc13h1 antibody
  • Unc13h2 antibody

Protein level used designations for UNC13A

protein unc-13 homolog A , UNC-13 homolog 1 , munc13 , protein unc-13 homolog B , unc-13 homolog A , unc13 homolog 1

GENE ID SPECIES
23025 Homo sapiens
382018 Mus musculus
64829 Rattus norvegicus
22249 Mus musculus
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