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Interaction between the tripartite NGL-1, netrin-G1 (show NTNG1 Proteins) and LAR (show PTPRF Proteins) adhesion complex promotes development of excitatory synapses.
NGL-1 is most abundant in the striatum and the cerebral cortex--the intermediate and final targets, of thalamocortical axons; surface-bound NGL-1 stimulates, but soluble NGL-1 disrupts, the growth of embryonic thalamic axons.
Axonal NGL-1 transneuronally determines lamina-specific subdendritic segments.
NGL1 is a specific binding partner for netrin G1 (NTNG1\; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003
leucine rich repeat containing 4 protein
, leucine-rich repeat-containing protein 4
, netrin-G1 ligand
, leucine-rich repeat-containing protein 4C
, netrin g1 ligand