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DYN (show PDYN ELISA Kits)-A(2-17) interacts with orexin A in the paraventricular hypothalamic nucleus to modulate food intake in mice.
Awake dynamics and brain-wide direct inputs of hypothalamic MCH (show PMCH ELISA Kits) and orexin/hypocretin networks have been discovered.
Histamine Transmission Modulates the Phenotype of Murine Narcolepsy Caused by Orexin Neuron Deficiency
observation that inhibition of the Orexin-1 receptor signaling blunted binge-like Ethanol, and saccharin drinking suggests that reward-related Orexin circuits participate in the consumption of salient reinforcers regardless of calories.
Results suggest that exercise produces antidepressant effects via suppression of Hcrt/Orx and melanin-concentrating hormone (show PMCH ELISA Kits) neural systems in the basolateral amygdala
Hcrt neuronal activity and Hcrt-mediated stress responses were inhibited by the satiety hormone leptin (show LEP ELISA Kits).
This study demonstrated that the GABAergic input property of orexin neurons responds rapidly to sleep deprivation.
sleep deprivation or increasing wakefulness by rescue of orexinergic neurons in APP (show APP ELISA Kits)/PS1 (show PSEN1 ELISA Kits) mice lacking orexin increased the amount of amyloid beta pathology in the brain.
orexin activates the mTOR (show FRAP1 ELISA Kits) pathway, a central regulator of cell growth and metabolism, in the mouse brain and cell lines that express GPCRs, OX1R (show HCRTR1 ELISA Kits), or OX2R (show CD200R1 ELISA Kits)
This study demonistrated that absence of the Hcrt peptide has gender-specific effects. In contrast, Hcrt-ataxin mice and human narcoleptics, with loss of the whole Hcrt cell, show weight gain in both sexes.
actigraphy gives additional information about the stabilization of sleep in patients with narcolepsy type 1; very low hypocretin levels associate with more wake intruding into sleep
There was also a negative correlation between Epworth sleepiness scale scores and orexin levels in Prader-Willi syndrome patients. Decreased cerebrospinal fluid orexin levels in Prader-Willi syndrome may play an important role in severity of obesity and excessive daytime sleepiness.
orexin system may be involved even in the earliest stages of AD, resulting in prolonged sleep latency, reduced sleep efficiency, and REM (show REM1 ELISA Kits) sleep impairment.
Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation is highly unlikely to be caused by mutations in the exons of the gene for hypocretin.
Data indicate a positive correlation of nesfatin-1 (show NUCB2 ELISA Kits) and a negative correlation of orexin-A with body mass index.
This study showed that orexin A induced autophagy through the ERK (show EPHB2 ELISA Kits) pathway in HCT116 human colon cancer cells.
This is the first time a seasonal variation of hcrt-1 levels has been shown, demonstrating that the hcrt system is, like other neurotransmitter systems, subjected to long term modulation
Significantly reduced csf (show CSF2 ELISA Kits) levels of hypocretin-1 were found in cluster headache patients compared with controls.
Results from homology and docking modeling show two alternative binding modes for orexin-A into orexin 1 receptor in concordance with what is known of G protein coupled receptors activation in general and the mutational data.
Patients with schizophrenia had a significantly higher plasma HCRT level than healthy controls. Patients in the high-orexin subgroup had significantly fewer negative and disorganized symptoms, and tended to have fewer perseverative errors.
The aim of the study was to determine by immunochemistry the expression of leptin (show LEP ELISA Kits), orexin A and orphanin FQ (show PNOC ELISA Kits) in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow.
first evidence for the expression of oxA and ox1R (show HCRTR1 ELISA Kits) in the vestibular glands of mammalian genital tract
The impact of the phase of the estrous cycle on the observed changes in plasma orexin levels in domestic pigs.
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.
Hypocretin (orexin) neuropeptide
, orexin A
, orexin B