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Human RAB3A Protein expressed in Escherichia coli (E. coli) - ABIN667484
Brondyk, McKiernan, Fortner, Stabila, Holz, Macara: Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A. in Molecular and cellular biology 1995
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Rab3a accelerates cell proliferation by increasing cyclin D1 (show CCND1 Proteins) expression, enhances anti-cancer drug resistance, and increases tumorigenicity and self-renewal of glioma cells.
Data indicate that exocytic stimuli promote ADP ribosylation factor 6 (ARF6 (show ARF6 Proteins)) activation, which accomplishes exocytosis by stimulating Rab3A GTP-Binding Protein.
Five compounds which possess good inhibitory activity and may act as potential high affinity inhibitors against Rab3A active site were identified
alpha-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity
Rab27 (show RAB27A Proteins) and Rab3 sequentially regulate human sperm dense-core granule exocytosis.
Myo5a (show MYO5A Proteins) and Rab3A are direct binding partners and interact on synaptic vesicles and the Myo5a (show MYO5A Proteins)/Rab3A complex is involved in transport of neuronal vesicles
Mutation screening of the RAB3A gene in 47 individuals with autism provided no evidence that DNA variants in this gene are associated with autism.
Cholesterol content regulates acrosomal exocytosis by enhancing Rab3A plasma membrane association.
In conclusion, we have found no evidence for RAB3A conferring susceptibility on mental retardation in the Han Chinese population.
Initiates exocytosis in acrosome when prenylated and activated with guanosine triphosphate (GTP (show AK3 Proteins)).
Rab3A might function as a marker of cortical granules and participates in cortical granule exocytosis in mouse eggs.
Rab3a deficiency promotes constitutive secretion and underlies selective impairment of Ca(2 (show CA2 Proteins))-dependent release of alpha-MSH
Rab3a deletion restores excitatory/inhibitory imbalance in synapsin II (show SYN2 Proteins)(-) hippocampal slices.
betaARs couple to a cAMP/Epac (show RAPGEF3 Proteins)/PLC (show HSPG2 Proteins)/Munc13-1/Rab3a/RIM1a-dependent pathway to enhance glutamate (show GRIN1 Proteins) release at cerebrocortical nerve terminals.
key role of Rab3a proteins control the balance between secretory vesicle biogenesis and degradation, and suggest that the ablation of this protein probably changes the nature of the reservoir of secretory vesicles available for regulated exocytosis.
Data show diminished actin plasticity in the cell processes of Rab3A knockout (KO) podocytes.
these findings suggest a crucial role of Rab3A in delivering vesicles to Ca2 (show CA2 Proteins)+ -dependent release sites at ribbon synapses.
Rab3A in the GTP (show AK3 Proteins) bound conformation prevents activity-dependent facilitation of exocytosis in bovine adrenal chromaffin cells
Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
ras-related protein Rab-3C
, RAB3D, member RAS oncogene family
, RAB3A, member RAS oncogene family
, ras-related protein Rab-3A
, RAS-associated protein RAB3A
, Ras-related small GTP binding protein 3A
, SMG P25A