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Mints are necessary for activity-induced APP (show APP Proteins) and PS1 (show PSEN1 Proteins) trafficking and provide insight into the cellular fate of APP (show APP Proteins) in endocytic pathways essential for Abeta (show APP Proteins) production.
Aberrant MINT2 methylation in body fluids may predict peritoneal micrometastasis for gastric cancer (GC) patients, which is a potential poor prognostic factor in GC.
a significant difference was shown for APBA2 gene expression of peripheral lymphocytes between Chinese Han Tourette syndrome (TS) group and healthy controls idicating the APBA2 gene is a promising peripheral blood biomarker that discriminates between patients with TS and healthy subjects
Amyloid beta A4 precursor protein-binding family A member 2 contains a potent neuronal promoter whose activity may be regulated by DNA methylation (show HELLS Proteins) and glucocorticoid receptor (show NR3C1 Proteins) [alpha], paired box protein 5 (show CAPS Proteins).
The co-occurrence of two nonsynonymous mutations in both affected siblings in a single family, each transmitted from a different unaffected parent, suggest a role for APBA2 mutations in rare individuals with ASD (show ARSD Proteins).
APBA2 were genes activated in early endometrial endometrioid carcinoma (stages I-II).
X11beta-mediated reduction in cerebral Abeta (show APP Proteins) is associated with cognition and long-term potentiation in Alzheimer's disease APPswe transgenic mice.
Interaction of transcriptional coactivators with Mint1 or Mint2 prevents nuclear localization and transactivation of the transduction network mediated by amyloid precursor protein (show APP Proteins).
The APBA2 gene has been found to map to a more telomeric location in chromosome 15q13 than previously found, and is partially duplicated within the broader region located approximately 5 Mb distal to the intact locus.
hXB51 isoforms regulate Abeta (show APP Proteins) generation differently, either enhancing it by modifying the association of X11L with APP (show APP Proteins) or suppressing it in an X11L-independent manner
Results indicate that both X11 and X11L exert largely in brain neurons, but X11 may also function in peripheral tissues.
X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice
X11L suppresses the amyloidogenic but not amyloidolytic processing of APP (show APP Proteins) in regions of the brain such as the hippocampus, which express significant levels of X11L.
shuttled between the cytoplasm and nucleus, the former more effectively than the latter; leptomycin B (LMB) induced substantial nuclear accumulation of EGFP-X11L
X11s associate primarily with APP (show APP Proteins) molecules that are outside of DRM (show GREM1 Proteins), that the dissociation of APP (show APP Proteins)-X11/X11L complexes leads to entry of APP (show APP Proteins) into DRM (show GREM1 Proteins), and that cleavage of uncomplexed APP (show APP Proteins) by BACE (show BACE Proteins) within DRM (show GREM1 Proteins)
This study suggested X11L is involved in the development of neuronal circuits that contribute to conflict resolution.
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene.
amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like)
, amyloid beta (A4) precursor protein-binding, family A, member 2
, amyloid beta A4 precursor protein-binding, family A, member 2
, amyloid beta A4 precursor protein-binding family A member 2
, X11-like protein
, adapter protein X11beta
, neuron-specific X11L protein
, neuronal munc18-1-interacting protein 2
, phosphotyrosine-binding/-interacting domain (PTB)-bearing protein
, Mint 2
, neuronal Munc18-1-interacting protein 2
, amyloid beta (A4) precursor protein-binding family A member 2 (X11-like)