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|Antigen||Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Antibodies|
|Conjugate||This CBL antibody is un-conjugated Alternatives|
Dot Blot (DB), Immunocytochemistry (ICC), Western Blotting (WB)
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Product Details anti-CBL AntibodyTarget Details CBL Application Details Handling Images
|Cross-Reactivity (Details)||Other species not studied.|
|Purification||Protein G affinity chromatography|
|Immunogen||CBL antibody was raised in mouse using recombinant Human Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (Cbl)|
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|Alternative Name||CBL (CBL Antibody Abstract)|
|Background||The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. Synonyms: Monoclonal CBL antibody, Anti-CBL antibody, Cas-Br-M (murine) ecotropic retroviral transforming sequence antibody, CBL2 antibody, C-CBL antibody, RNF55 antibody.|
|Research Area||Cancer, Transcription Factors, Proteolysis / Ubiquitin, DNA/RNA|
|Pathways||TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals|
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WB: 0.2-2 µg/mL
Optimal conditions should be determined by the investigator.
|Restrictions||For Research Use only|
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|Buffer||CBL antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).|
|Precaution of Use||This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.
|Storage Comment||Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.|
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