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HLA-DQB1 (show HLA-DQB1 Proteins)/HLA-DQA2 rs9275328 may play a part in influencing the systemic lupus erythematosis susceptibility in Malays and Chinese in Malaysia.
HLA-DQA2 and HLA-DQB2 genes are expressed in human Langerhans cells and encode a new HLA class II molecule.
Parkinson's disease-associated SNP4 is correlated (r2=0.95) with variants that are associated with HLA-DQA2 expression.
Results indicate that two SNPs rs9468925 in HLA-C/HLA-B and rs2858881 in HLA-DQA2 were repeatedly selected in all models, suggesting that multiple loci outside PSOR1 (show S100A7 Proteins) locus were associated with psoriasis.
a significant single nucleotide polymorphism , rs3998159, between HLA-DQB1 (show HLA-DQB1 Proteins) and HLA-DQA2 was identified in patients with asthma
This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells.
DX alpha chain
, HLA class II histocompatibility antigen, DQ alpha 2 chain
, HLA class II histocompatibility antigen, DQ(6) alpha chain
, MHC class II DQA2