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Polymorphisms in CYBRD1 modulates iron phenotype in HFE (show HFE Proteins) p.C282Y homozygous hemochromatosis (show HFE Proteins).
Letter: report mutations in CYBRD1 promoter in and possible role in iron hemostasis in patients with porphyria cutanea tarda.
In Africans with iron overload not related to the HFE (show HFE Proteins) gene, the possible involvement of the SLC40A1 (show SLC40A1 Proteins) and CYBRD1 genes was demonstrated for the first time.
Duodenal cytochrome b present in human erythrocytes may contribute to their ability to reduce extracellular monodehydroascorbate.
Functional characterization of Cybrd1 heme groups and iron/ascorbate metabolism.
The results of this study confirm that Dcytb can act as a ferric reductase that stimulates iron uptake in Caco-2 cells.
It was concluded that Cybrd1 is the primary iron-regulated duodenal ferric reductase in the gut (show GUSB Proteins) and that it is necessary for optimal iron metabolism.
Increased iron absorption reported in early hypoxia could be accounted for in part by the enhancement of Dcytb expression by Hif-2alpha (show EPAS1 Proteins) in the duodenum.
Regulatory defects in liver and intestine implicate abnormal hepcidin (show HAMP Proteins) and Cybrd1 expression in hemochromatosis (show HFE Proteins).
Dcytb, DMT1 (show SLC11A2 Proteins), Ireg1 (show SLC40A1 Proteins) and transferrin receptor 1 (show TFR Proteins) have roles in iron transport and hemolysis
Iron absorption genes(Dcytb,IREG1 (show SLC40A1 Proteins),DMT1 (show SLC11A2 Proteins))were expressed at lower levels in mouse caecum and colon than in the duodenum. They are regulated by body iron requirements.
loss of Cybrd1 had little or no impact on body iron stores, even in the setting of iron deficiency; other mechanisms must be available for the reduction of dietary iron
cybrd1 is nonessential in mice
Dcytb plays a physiological role in both iron and copper uptake, through divalent metal transporter 1 (DMT1 (show SLC11A2 Proteins)) and copper transporter 1 (show SLC31A1 Proteins), respectively.
This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption.
cytochrome b reductase 1
, cytochrome b561 family, member A2
, duodenal cytochrome b
, ferric-chelate reductase 3