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Browse our Feline Leukemia Virus Subgroup C Cellular Receptor 1 Proteins (FLVCR1)

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Feline Leukemia Virus Subgroup C Cellular Receptor 1 Proteins (FLVCR1)
On www.antibodies-online.com are 5 Feline Leukemia Virus Subgroup C Cellular Receptor 1 (FLVCR1) Proteins from 2 different suppliers available. Additionally we are shipping Feline Leukemia Virus Subgroup C Cellular Receptor 1 Antibodies (50) and many more products for this protein. A total of 59 Feline Leukemia Virus Subgroup C Cellular Receptor 1 products are currently listed.
Synonyms:
9630055N22Rik, AXPC1, FLVCR, Flvcr1, MFSD7B, PCA, PCARP, si:ch211-147d7.6
list all proteins Gene Name GeneID UniProt
FLVCR1 28982 Q9Y5Y0
FLVCR1 226844  

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Feline Leukemia Virus Subgroup C Cellular Receptor 1 Proteins (FLVCR1) by Origin

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More Proteins for Feline Leukemia Virus Subgroup C Cellular Receptor 1 Interaction Partners

Human Feline Leukemia Virus Subgroup C Cellular Receptor 1 (FLVCR1) interaction partners

  1. RPS19 (show RPS19 Proteins)-downregulated erythroleukemia cells show reduced FLVCR1a and FLVCR1b mRNA levels associated with heme overload.

  2. Flvcr1 regulates differentiation of erythroid progenitors by controlling intracellular heme accumulation.

  3. both HIF2alpha (show EPAS1 Proteins) and ETS1 (show ETS1 Proteins) are involved in the transcriptional regulation of Flvcr1a and that HIF2alpha (show EPAS1 Proteins) is absolutely required for Flvcr1a induction upon hypoxia

  4. FLVCR1 mutants failed to fold properly in the ER, were rapidly degraded in the lysosomes, and therefore, could not export heme out of cells. Thus, accumulation of heme in FLVCR1-mutant cells could cause cellular toxicity.

  5. Study identified sequence variants in the known disease-causing genes SLC6A3 (show SLC6A3 Proteins) and FLVCR1, and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6, BRAT1 (show C7orf27 Proteins), SNIP1 (show SNIP1 Proteins), CRADD (show CRADD Proteins), and HARS (show HARS Proteins).

  6. Posterior column ataxia (show USP14 Proteins) with retinitis pigmentosa is caused by mutations in FLVCR1.

  7. relative protein expression of 2 heme transporters, Feline Leukemia Virus, Subgroup C, Receptor 1 (FLVCR1) and Breast Cancer Resistance Protein, was assessed in placental tissue in relation to maternal/neonatal iron status and placental iron concentration

  8. These results suggest that aberrant FLVCR1 causes a selective degeneration of a subpopulation of neurons in the retina and the posterior columns of the spinal cord via dysregulation of heme or iron homeostasis.

  9. hemopexin (show HPX Proteins) directly interacts with FLVCR

  10. the FLVCR gene on 1q31 is not involved in Diamond-Blackfan anemia in families studied

Mouse (Murine) Feline Leukemia Virus Subgroup C Cellular Receptor 1 (FLVCR1) interaction partners

  1. study found that primary and immortalized murine macrophages downregulate Flvcr mRNA levels upon LPS (show TLR4 Proteins) stimulation; findings point to a new role for FLVCR and heme export in macrophages responses to infection and inflammation

  2. These studies identify a novel and unexpected role for FLVCR, a major facilitator superfamily metabolite transporter, in T cell development

  3. Flvcr1a maintains a free heme pool that regulates heme synthesis and degradation as well as cytochromes P450 (show POR Proteins) expression and activity.

  4. FLVCR is redundant in stem cells but has critical and contrasting stage-specific roles in discrete hematopoietic lineages

  5. Hemochromatosis (show HFE Proteins) is associated not only with excessive accumulation of free iron in the retina and retinal pigment epithelium but also with excessive accumulation of heme.

  6. data show that FLVCR exports heme & is required by erythroid progenitors to complete terminal differentiation; data show that FLVCR functions in macrophage heme-iron recycling and that systemic iron balance involves heme-iron trafficking via FLVCR

Feline Leukemia Virus Subgroup C Cellular Receptor 1 (FLVCR1) Protein Profile

Protein Summary

This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome.

Alternative names and synonyms associated with Feline Leukemia Virus Subgroup C Cellular Receptor 1 (FLVCR1)

  • feline leukemia virus subgroup C cellular receptor 1 (FLVCR1)
  • feline leukemia virus subgroup C cellular receptor 1 (flvcr1)
  • feline leukemia virus subgroup C cellular receptor (FLVCR)
  • major facilitator superfamily domain containing 7B (Mfsd7b)
  • 9630055N22Rik protein
  • AXPC1 protein
  • FLVCR protein
  • Flvcr1 protein
  • MFSD7B protein
  • PCA protein
  • PCARP protein
  • si:ch211-147d7.6 protein

Protein level used designations for FLVCR1

feline leukemia virus subgroup C cellular receptor 1 , feline leukemia virus subgroup C receptor-related protein 1 , feline leukemia virus subgroup C receptor-related protein 1-like , feline leukemia virus subgroup C cellular receptor , eline leukemia virus subgroup C cellular receptor 1

GENE ID SPECIES
421365 Gallus gallus
490285 Canis lupus familiaris
533317 Bos taurus
562595 Danio rerio
100022877 Monodelphis domestica
100050536 Equus caballus
100217398 Sus scrofa
100358453 Oryctolagus cuniculus
100407159 Callithrix jacchus
100442230 Pongo abelii
100492275 Xenopus (Silurana) tropicalis
100606448 Nomascus leucogenys
710008 Macaca mulatta
28982 Homo sapiens
457724 Pan troglodytes
493854 Felis catus
226844 Mus musculus
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