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Mouse (Murine) Lactoferrin Protein expressed in Human Cells - ABIN2008272
Azzam, Goertz, Fritts, Jonas: Natural products and chronic hepatitis C virus. in Liver international : official journal of the International Association for the Study of the Liver 2007
Because microbes actively target lactoferrin to acquire iron, we propose that the emergence of antimicrobial activity provided a pivotal mechanism of adaptation sparking evolutionary conflicts via acquisition of new protein functions.
Most of the variation in the ability of human apo (show C9orf3 Proteins)-hLf (show EPAS1 Proteins) to kill Streptococcus pneumoniae is dependent on the variation in the binding of apo (show C9orf3 Proteins)-hLf (show EPAS1 Proteins) to surface PspA and this binding is dependent on variation in PspA as well as variation in capsule which may enhance killing by reducing the binding of apo (show C9orf3 Proteins)-hLf (show EPAS1 Proteins) to PspA.
These observations suggest that lactoferrin serves as an intrinsic inhibitor of NETs release into the circulation. Thus, lactoferrin may represent a therapeutic lead for controlling NETs release in autoimmune and/or inflammatory diseases.
3 LTF tag SNPs were genotyped; allele A was found to be significantly less frequent in the polarization group, conferring a protective effect against caries experience. Results might contribute to the understanding of the genetic control of caries susceptibility.
Fecal lactoferrin (FL), as a noninvasive and screening marker, has a high specificity and a modest specificity during the diagnosis of suspected inflammatory bowel disease (IBD).
Lactoferrin modulates parameters of sperm function. The inhibition of gamete interaction by LF could be partially explained by the decrease in sperm d-mannose-binding sites. The presence of the LF promoted sperm capacitation in vitro.
This study showed that recombinant lactoferrin had antibacterial activity on Salmonella infection.
LTF C-lobe contributes to its anti-tumor activity.
M-860 induces the activation of huPMNs partially through TLR4 (show TLR4 Proteins) ... M-860 is thus a powerful tool to analyze the expression and function of human mbLTF, which will further our understanding of the roles of LTF in health and disease.
LF triggered CREB1 (show CREB1 Proteins) phosphorylation in IL-1beta (show IL1B Proteins)-induced Human articular chondrocytes apoptosis through AKT1 (show AKT1 Proteins) signaling.
Bovine lactoferrin SNPs -270T>C and -156A>G showed close linkage disequilibrium (r(2)=0.76). The SNP -190G>A showed a significant association with SCS (show TWIST1 Proteins), and individuals with genotype GG had higher SCS (show TWIST1 Proteins) than genotypes AG and AA.
Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin (show BDNF Proteins) factor (BDNF (show BDNF Proteins)) signaling pathway.
Results from this study indicated the probable role played by Lactoferrin promoter to serve as candidate gene for mastitis susceptibility among indigenous and crossbred milch cattle.
Supplementation with lactoferrin (1,600 mg/kg per day) effectively suppressed the increase in transepidermal water loss, reduction in skin hydration, aberrant epidermal hyperplasia, and cell apoptosis induced by UV irradiation.
Bovine Lf can capture and terminate the cycle of ROS (show ROS1 Proteins) production by heme iron. Luminal iron binding properties of Lf might assist in regulating excess levels of stored iron and down-regulate ferritin (show FTL Proteins) production and associated pro-inflammatory signaling.
The results showed potent stimulation of the proliferative response of PBMC by bovine lactoferrin, associated with the induction of proinflammatory cytokines only in the case of colostral bovine lactoferrin.
Lactoferrin (10 and 100 mug/mL) effectively inhibits apoptosis of primary rat osteoblasts by upregulating IGF-I (show IGF1 Proteins) expression.
The the association between single nucleotide polymorphism (A/C) in position -28 located in the TATA box of LTF gene and the lactoferrin concentration in bovine milk secreted by healthy and infected udders.
This study showed that neutrophils from periparturient heifers show impairment of COX-2 (show PTGS2 Proteins) mRNA expression and lactoferrin, suggesting that these mechanisms may contribute to immunosuppression in cows around calving.
results suggest a two-step mechanism, whereby LfcinB induces TIMP-1 (show TIMP1 Proteins) through an IL-11 (show IL11 Proteins)-dependent pathway involving transcription factor AP-1 (show JUN Proteins) and STAT3 (show STAT3 Proteins).
Data indicate that lactoferrin uptake across duodenum by glyceraldehyde-3-phosphate dehydrogenase (GAPDH (show GAPDH Proteins)).
Results show that LTF gene expression is downregulated in colorectal cancer tumors and its knock out in mouse model of colitis-associated colorectal dysplasia suggests its protective role in colorectal mucosal immunity and inflammation.
Data show that the expression of several genes encoding salivary antimicrobial proteins, such as secretory leukocyte peptidase inhibitor (SLPI (show SLPI Proteins)), S100A8 (show S100A8 Proteins), and lactotransferrin, was reduced due to myeloid differentiation dactor 88 (MyD88 (show MYD88 Proteins)) deficiency.
Lactoferrin dampens high-fructose corn syrup-induced hepatic manifestations of the metabolic syndrome in a murine model.
We conclude that lactotransferrin represents a late stage differentiation marker of neutrophils, macrophages and distinct subtypes of dendritic cells.
The variations in lactoferrin expression levels during developmental stages may be related to its regulatory role in mouse mammary gland immunity.
the present work indicated that LF stimulated MC3T3-E1 preosteoblast differentiation mainly through LRP1 (show LRP1 Proteins)-independent PKA and p38 (show CRK Proteins) signaling pathways.
Studie indicate that in iCre knock-in line, the iCre is expressed from endogenous lactoferrin (Ltf) promoter.
administration of lactoferrin led to autopotentiated increased expression of the LTF gene. The decreased lactoferrin mRNA levels in association with obesity and diabetes were replicated in mice adipose tissue
The up-regulation of lactorferrin in the brains of the transgenic mouse model of Alzheimer's disease provides evidence of an important role for lactoferrin in alzheimer disease-affected brain tissues
lactoferrin was found in the cytoplasm of principal cells in the corpus and cauda of the epididymis in peri (show PLIN1 Proteins)- and post-pubertal, but not pre-pubertal stallions. Further, lactoferrin binds to sperm, suggesting a role for protection or regulation of sperm.
These data indicate that clinically normal skin of horses affected by CHS is not characterized by modified maintenance levels of lactoferrin mRNA.
this paper shows that recombinant lactoferrin peptide LF-6 produced with intein technology has both antibacterial and immunomodulatory activity in mice
We propose that lactoferrin functions in the immune defense of the small intestinal mucosa by targeting the population of T cells in the lamina propria
Involvement of HSP27 (show HSPB1 Proteins) and lactoferrin in porcine endometrium and neutrophils activity.
Growth performance of animal pups is enhanced by directly feeding the genetically engineered milk containing enriched pLF protein in transgenic mice.
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, growth-inhibiting protein 12
, neutrophil lactoferrin
, N lobe
, minisatellite 10r detected by probe MMS10
, allergen Gal d III
, ovotransferrin BB type
, ovotransferrin BC type
, ovotransferrin CC type
, serum transferrin