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anti-Human SLC25A37 Antibodies:
anti-Rat (Rattus) SLC25A37 Antibodies:
anti-Mouse (Murine) SLC25A37 Antibodies:
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RNA-sequencing and Reverse transcriptase PCR showed higher expression of a specific isoform of SLC25A37 in SF3B1 (show SF3B2 Antibodies)-mutant patients, a crucial importer of Fe(2+) into the mitochondria
Compares and contrasts all the known human SLC25A (show SLC25A25 Antibodies)* genes and includes functional information.
Data show that abnormal MFRN1 expression can contribute to erythropoietic protoporphyria (show FECH Antibodies) phenotype in some patients, probably by causing a reduction in FECH (show FECH Antibodies) activity.
hypoxia induces the expression of mitoferrin mRNAs through separate mechanisms in erythroid cells
impaired mitochondrial [Fe-S] cluster biogenesis in Mfrn1(gt/gt (show FABP6 Antibodies)) cells results in elevated IRP1 (show ACO1 Antibodies) RNA-binding that attenuates ALAS2 (show ALAS2 Antibodies) mRNA translation and protoporphyrin accumulation
Mitoferrin 1 can cause anemia and protoporphyria (show FECH Antibodies).
The transcription factor GATA-1 (show GATA1 Antibodies) controls expression of Mitoferrin 1 in development of mammals
Fech (show FECH Antibodies) forms an oligomeric complex with Mfrn1 and Abcb10 (show ABCB10 Antibodies) to synergistically integrate mitochondrial iron importation and use for heme biosynthesis.
Erythroblasts generated from murine embryonic stem cells null for Mfrn (also known as Slc25a37) show maturation arrest with severely impaired incorporation of 55Fe into haem [mitoferrin]
Mitoferrin 1 and mitoferrin 2 (show SLC25A28 Antibodies) contribute to mitochondrial iron delivery in a variety of cells.
Data show that the binding domain of Mfrn1-Abcb10 (show ABCB10 Antibodies) interaction maps to the N terminus of Mfrn1.
SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009
solute carrier family 25, member 37
, erythroid-specific mitochondrial mitoferrin
, mitochondrial iron transporter 1
, protein frascati
, mitochondrial solute carrier protein
, predicted protein of HQ2217
, mitochondrial carrier domain containing protein RGD1359361
, mitochondrial solute carrier-like protein
, mitoferrin 1
, solute carrier family 25 member 37