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This study demonstrated that identified genetic overlap between Alzheimer Disease disease and immune-mediated diseases, implicating the HLA locus and IPMK in the pathobiology of Alzheimer Disease.
a severe loss of IPMK in the striatum of Huntington disease (show HTT Proteins) patients and in several cellular and animal models of the disease, is reported.
A hereditary form of small intestinal carcinoid associated with a germline mutation in IPMK.
Future research should focus on the hitherto unknown non-conventional import of IPMK and the potential impact of its dysregulation on IPMK signaling pathways regulating cellular growth and proliferation.
Knockdown of expression and/or inhibition of function of phospholipase Cgamma1, inositol polyphosphate multikinase, which generates inositol 1,3,4,5-tetrakisphosphate (InsP) and InsP, and inositol hexakisphosphate kinase 1 (show IP6K1 Proteins)/2
Our findings implicate IPMK in a transcript-selective mRNA export pathway controlled by phosphoinositide turnover that preserves genome integrity in humans.
Results suggest that inositol polyphosphate multikinase (IPMK) acts as a transcriptional coactivator for p53 (show TP53 Proteins) and that it is an integral part of the p53 (show TP53 Proteins) transcriptional complex facilitating cell death.
overview of possible roles of IPMK in regulation of metabolism: IPMK appears to mediate activation of mammalian target of rapamycin (mTOR (show FRAP1 Proteins)) in response to essential amino acids. IPMK appears to mediate hypothalamic control of food intake. [REVIEW]
Data show that inositol polyphosphate multikinase (IPMK) interacts with the nuclear receptor steroidogenic factor 1 (SF-1 (show NR5A1 Proteins)) and phosphorylates its bound ligand Phosphatidylinositol 4,5-bisphosphate (PIP (show PIP Proteins)).
Phosphorylation of S284 by protein kinase CK2 (show CSNK2A1 Proteins) significantly decreases nuclear targeting of IPMK in HEK (show EPHA3 Proteins)-293 cells.
metformin-mediated activation of AMP (show TMPRSS5 Proteins)-Activated Protein Kinases was impaired in the absence of IPMK.
Inositol polyphosphate multikinase is a coactivator for serum response factor-dependent induction of immediate early (show JUN Proteins) genes.
Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early (show JUN Proteins) gene induction.
IPMK regulates glucose signaling to AMPK (show PRKAA1 Proteins) in a pathway whereby glucose activates phosphorylation of IPMK at tyrosine 174 enabling the enzyme to bind to AMPK (show PRKAA1 Proteins) and regulate its activation.
Data show that in MEFs lacking IPMK, synthesis of IP5 and IP7 is abolished, but IP6 (show GPRIN2 Proteins) formation is reduced about 90%.
Inositol polyphosphate multikinase (Ipk2) plays a major role in the synthesis of inositol polyphosphate messengers derived from inositol 1,4,5-trisphosphate in embryogenesis and normal development.
This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19.
inositol polyphosphate multikinase
, inositol 1,3,4,6-tetrakisphosphate 5-kinase
, inositol polyphosphate kinase 2