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Findings demonstrate that miR (show MLXIP Proteins)-1238 inhibit the proliferation of NSCLC cells at least partly via repression of LHX2, shedding light on the mechanistic interaction of miR (show MLXIP Proteins)-1238 and LHX2 in NSCLC carcinogenesis.
Results show that LHX2 is overexpressed in pancreatic ductal adenocarcinoma cells and is involved in promoting cancer cell proliferation and enhanced tumor development.
Lhx2 directly regulates tanycyte specification and differentiation in the hypothalamus.
This study demonistrated that LHx2 regulates the development of the forebrain hem system.
The data indicate a dual role of Lhx2 during EMT (show ITK Proteins) and tumor progression: by inducing the expression of PDGF-B (show PDGFB Proteins), Lhx2 provokes an autocrine PDGF-B (show PDGFB Proteins)/PDGFRbeta loop required for cell migration, invasion and metastatic dissemination
The findings indicate that LHX2 regulates the transcription of downstream intrinsic and extrinsic molecules that are essential for early neural differentiation.
These results suggest that if LHX2 is involved in pituitary hormone (show CGA Proteins) deficiency associated with posterior pituitary and ocular defects, it would be a rare cause of this disease condition.
Mutations in LHX2 do not represent a frequent cause of micro/anophthalmia.
A large cohort of patients with schizencephaly, some with features of septo-optic dysplasia, were sequenced for mutations in LHX2, HESX1 (show HESX1 Proteins) and SOX2 (show SOX2 Proteins).
Lhx2 expression during porcine fetal and postnatal pituitary development showed a gradual increase from fetal day (f) 40 to postnatal day (p) 8 followed by a slight decrease to p230 (show TNC Proteins).
Lack of Lhx2/Lhx9 function as well as increased Wnt signaling alter the expression of the thalamus specific cell adhesion factor pcdh10b and lead subsequently to a striking anterior-posterior disorganization of the caudal forebrain.
Lhx2 may mediate an alternative or parallel pathway for control of cellular proliferation in the developing forebrain via Six3.
LHX2 is a key component of the control network for producing neurons that will participate in cortical circuitry
We found that expression of Emx2 (show EMX2 Proteins) and Lhx2 initiated between neuronal progenitor and neuronal precursor stages. As far as the sensory neurons of the vomeronasal organ are concerned, Meis1 (show MEIS1 Proteins) and Meis2 (show MEIS2 Proteins) were only expressed in the apical layer, together with Gnai2 (show GNAI2 Proteins), but not in the basal layer.
Lhx2 is required for maintenance of the corneal epithelial cell compartment and the limbal barrier.
The ectopic expression of Lhx2 in OP9 cells (OP9-Lhx2) accelerates the hematopoietic differentiation of PSCs.
Conditional knock-out of Lhx2 resulted in down-regulation of Notch (show NOTCH1 Proteins) pathway genes in retinal glia.
These studies define essential roles for Lhx2 in glial wedge, hippocampal commissure, and corpus callosum formation, and suggest that defects in radial glial wedge progenitors can give rise to corpus callosum.
CTIP2 transcription factor maintains stem cells in hair follicle and alters LHX2 expression.
Lhx2 regulates the timing of beta-catenin (show CTNNB1 Proteins)-dependent cortical neurogenesis.
Lhx2 controls neocortical area patterning by regulating downstream genetic and epigenetic regulators that drive the acquisition of molecular properties in cortical plate neurons.
Lhx2 acts as a negative regulator of osteoclast formation in vitro and in vivo.
This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.
LIM homeobox protein 2
, LIM homeodomain
, LIM/homeobox protein Lhx2
, LIM HOX gene 2
, homeobox protein LH-2
, LIM homeobox 2
, LIM homeodomain type transcription factor Lhx2
, LIM homeo box protein 2