ABCE1 antibody
This anti-ABCE1 antibody is a Rabbit Polyclonal antibody detecting ABCE1 in WB. Suitable for Human, Mouse and Rat.
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Catalog No. ABIN5708515
Quick Overview for ABCE1 antibody (ABIN5708515)
Target
ABCE1 (RLI1)
(ABC Transporter E Family Member 1 (RLI1))
Reactivity
Human, Mouse, Rat
Host
Rabbit
Clonality
Polyclonal
Application
Western Blotting (WB)
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Purification
- Antigen affinity purified
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Immunogen
- Amino acids K419-D599 from the human protein were used as the immunogen for the ABCE1 antibody.
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Isotype
- IgG
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Application Notes
- Western blot: 0.5-1 μg/mL
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Restrictions
- For Research Use only
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Buffer
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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Storage
- -20 °C
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Storage Comment
- After reconstitution, the ABCE1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- ABCE1 (RLI1) (ABC Transporter E Family Member 1 (RLI1))
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Alternative Name
- ABCE1 / ATP binding cassette E1
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Background
- ATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumorcell proliferation and antiapoptosis.
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UniProt
- P61221
Target
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