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ATIC encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. Additionally we are shipping ATIC Proteins (12) and and many more products for this protein.
Showing 10 out of 90 products:
Fruit Fly (Drosophila melanogaster) Monoclonal ATIC Primary Antibody for IHC (p), WB - ABIN2477543
Rattan, Giri, Singh, Singh: 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. in The Journal of biological chemistry 2005
ATIC acts as an oncogenic gene that promotes survival, proliferation and migration by targeting AMPK (show PRKAA1 Antibodies)-mTOR (show FRAP1 Antibodies)-S6 K1 signaling
The AICARFT site is capable of independently binding both nucleotide and folate substrates with high affinity however no evidence for positive cooperativity in binding could be detected using the model ligands employed in this study.
Pediatric Osteosarcoma patients with ATIC 347C>G exhibited a good histologic response to chemotherapy
The ATIC 347 C/G polymorphism may be associated with non-responsiveness to and or toxicity of methotrexate in Caucasian rheumatoid arthritis patients.
ATIC 347C>G gene polymorphism may be associated with the development of MTX (show MTX1 Antibodies) induced gastrointestinal adverse events.
genotyping of ATIC rs2372536 and ITPA (show ITPA Antibodies) rs1127354 variants or measuring ITPA (show ITPA Antibodies) activity could be useful to predict methotrexate response in children with juvenile idiopathic arthritis.
This study shows that polymorphisms on genes related to the metabolic pathway of pemetrexed, especially, ATIC and GGH (show GGH Antibodies) genes, would have a therapeutic implication in pemetrexed-treated patients with lung adenocarcinoma
Our data show that ATIC is in complex with insulin receptor (IR (show INSR Antibodies))and siRNA-mediated partial knockdown of ATIC in HEK293 cells, decreases IR tyrosine phosphorylation and regulates IR endocytosis. Insulin (show INS Antibodies) stimulation and ATIC knockdown readily increase level of AMPK (show PRKAA1 Antibodies)-Thr172 phosphorylation in IR complexes.ATIC depletion delayed insulin (show INS Antibodies) response of Glut2 (show SLC2A2 Antibodies) translocation in HEK293 cells and decreased AKT (show AKT1 Antibodies)-Ser473 phosphorylation.
Single nucleotide polymorphisms in ATIC gene is associated with acute graft-versus-host disease.
MTHFR (show MTHFR Antibodies), DHFR (show DHFR Antibodies) and ATIC genetic variants can be considered as pharmacogenetic markers of outcome in RA patients under MTX (show MTX1 Antibodies) monotherapy.
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.
bifunctional purine biosynthesis protein PurH
, bifunctional purine biosynthesis protein purH
, Bifunctional purine biosynthesis protein purH
, Bifunctional purine biosynthesis protein PurH
, 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase
, AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme
, bifunctional purine biosynthesis protein PURH
, phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
, 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase, ATIC
, aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase
, aminoimidazole-4-carboxamide ribonucleotidetransformylase/IMP cyclohydrolase
, bifunctional purine biosynthesis protein