anti-5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC) Antibodies

ATIC encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. Additionally we are shipping ATIC Proteins (12) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ATIC 471 P31939
ATIC 108147 Q9CWJ9
ATIC 81643 O35567
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Top anti-ATIC Antibodies at antibodies-online.com

Showing 10 out of 89 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-ATIC Antibody Titration:  1.25ug/ml  Positive Control:  HepG2 cell lysate ATIC is supported by BioGPS gene expression data to be expressed in HepG2 Sample Type: 1. Hamster CHO K1 cells (20ug)2. HeLa skin cells(20ug)3. HEK273 cells (20ug)4. Human Skin Fibroblats (100ug)Primary Dilution: 1:800Secondary Antibody: Clean-Blot IP detection Reagent and KitSecondary Dilution: 1:2000Image Submitted By: V. Skopova, M. ZikanovaInstitute of Inherited Metabolic Disorders, Charles University in Prague and General Hopspital in Prague 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Rabbit Un-conjugated IHC, WB Human kidney 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IF, IHC, WB 100 μL Log in to see 16 Days
$366.77
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: Hep G2 , 7.5% SDS PAGE ATIC antibody antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using ATIC, antibody at 1:100 dilution. 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: ATIC Antibody [NBP1-89192] - Staining of human cell line A-431 shows positivity in plasma membrane & cytoplasm. Immunohistochemistry-Paraffin: ATIC Antibody [NBP1-89192] - Staining of human colon shows strong cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Cow Mouse Un-conjugated IHC, IHC (p), WB Anti-ATIC antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN962072 concentration 10 ug/ml. Anti-ATIC antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Fruit Fly Rabbit Un-conjugated WB 100 μg Log in to see 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of Hepg2 whole cell lysates, using ATIC Antibody. The lane on the left is treated with the antigen-specific peptide. Western blot analysis of extracts from HepG2, using ATIC Antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Mouse Un-conjugated WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ATIC (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-ATIC. 0.1 mL Log in to see 2 to 3 Days
$451.00
Details
Human Mouse Un-conjugated WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ATIC (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-ATIC. 0.1 mL Log in to see 2 to 3 Days
$451.00
Details

Top referenced anti-ATIC Antibodies

  1. Fruit Fly (Drosophila melanogaster) Monoclonal ATIC Primary Antibody for IHC (fro), WB - ABIN533582 : Bulock, Beardsley, Anderson et al.: The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate ... in The Journal of biological chemistry 2002 (PubMed)
    Show all 3 Pubmed References

More Antibodies against ATIC Interaction Partners

Human 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC) interaction partners

  1. ATIC acts as an oncogenic gene that promotes survival, proliferation and migration by targeting AMPK-mTOR-S6 K1 signaling

  2. The AICARFT site is capable of independently binding both nucleotide and folate substrates with high affinity however no evidence for positive cooperativity in binding could be detected using the model ligands employed in this study.

  3. Pediatric Osteosarcoma patients with ATIC 347C>G exhibited a good histologic response to chemotherapy

  4. The ATIC 347 C/G polymorphism may be associated with non-responsiveness to and or toxicity of methotrexate in Caucasian rheumatoid arthritis patients.

  5. ATIC 347C>G gene polymorphism may be associated with the development of MTX induced gastrointestinal adverse events.

  6. genotyping of ATIC rs2372536 and ITPA rs1127354 variants or measuring ITPA activity could be useful to predict methotrexate response in children with juvenile idiopathic arthritis.

  7. This study shows that polymorphisms on genes related to the metabolic pathway of pemetrexed, especially, ATIC and GGH genes, would have a therapeutic implication in pemetrexed-treated patients with lung adenocarcinoma

  8. Our data show that ATIC is in complex with insulin receptor (IR)and siRNA-mediated partial knockdown of ATIC in HEK293 cells, decreases IR tyrosine phosphorylation and regulates IR endocytosis. Insulin stimulation and ATIC knockdown readily increase level of AMPK-Thr172 phosphorylation in IR complexes.ATIC depletion delayed insulin response of Glut2 translocation in HEK293 cells and decreased AKT-Ser473 phosphorylation.

  9. Single nucleotide polymorphisms in ATIC gene is associated with acute graft-versus-host disease.

  10. MTHFR, DHFR and ATIC genetic variants can be considered as pharmacogenetic markers of outcome in RA patients under MTX monotherapy.

  11. study suggests that MTHFR C677T and ATIC T675C genotyping combined with clinicopathological data may help to identify patients whom will not benefit from MTX treatment and, therefore, assist clinicians in personalizing RA treatment

  12. Results proved in cultured skin fibroblasts from patients with AICA-ribosiduria that various mutations of ATIC destabilize to various degrees purinosome assembly.

  13. The kinetic mechanism of the human bifunctional enzyme ATIC

  14. crystal structure of ATIC

  15. Deficiency in AICAR transformylase is associated with severe neurological defects and congenital blindness

  16. Polymorphisms of reduced folate carrier,aminoimidazole carboxamide ribonucleotide transformylase,and thymidylate synthase genes contribute to the therapeutic response in rheumatoid arthritis patients to methotrexate.

  17. AS160 is a common target of insulin, IGF-1, EGF, PMA and AICAR, these stimuli induce distinctive patterns of phosphorylation and 14-3-3 binding, mediated by at least four protein kinases.

  18. ATIC associated with nucleophosmin-ALK, and its phosphorylation required ALK activity. ALK-mediated ATIC phosphorylation enhanced its enzymatic activity.

ATIC Antigen Profile

Protein Summary

This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.

Gene names and symbols associated with ATIC

  • 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase L homeolog (atic.L) antibody
  • bifunctional purine biosynthesis protein PurH (purH) antibody
  • bifunctional purine biosynthesis protein purH (purH) antibody
  • Bifunctional purine biosynthesis protein purH (purH) antibody
  • Bifunctional purine biosynthesis protein PurH (purH) antibody
  • 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) antibody
  • 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (Atic) antibody
  • 2610509C24Rik antibody
  • AA536954 antibody
  • AICAR antibody
  • AICARFT antibody
  • AW212393 antibody
  • IMPCHASE antibody
  • purH antibody

Protein level used designations for ATIC

bifunctional purine biosynthesis protein PurH , bifunctional purine biosynthesis protein purH , Bifunctional purine biosynthesis protein purH , Bifunctional purine biosynthesis protein PurH , 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase , AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme , AICARFT/IMPCHASE , bifunctional purine biosynthesis protein PURH , phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase , 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase, ATIC , aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase , aminoimidazole-4-carboxamide ribonucleotidetransformylase/IMP cyclohydrolase , bifunctional purine biosynthesis protein

GENE ID SPECIES
735175 Xenopus laevis
1064322 Tropheryma whipplei TW08/27
1795643 Rhodopirellula baltica SH 1
3726377 Carboxydothermus hydrogenoformans Z-2901
3852615 Salinibacter ruber DSM 13855
4056143 Baumannia cicadellinicola str. Hc (Homalodisca coagulata)
4289939 Hyphomonas neptunium ATCC 15444
6413645 Cellvibrio japonicus Ueda107
6944185 Coprothermobacter proteolyticus DSM 5265
6945486 Dictyoglomus thermophilum H-6-12
7355505 Thermomicrobium roseum DSM 5159
8213748 Teredinibacter turnerae T7901
8220261 Neorickettsia risticii str. Illinois
8867387 Deferribacter desulfuricans SSM1
8984725 Bacillus megaterium QM B1551
8996427 Salinibacter ruber M8
9115672 Bacillus megaterium DSM 319
9399564 Leuconostoc gasicomitatum LMG 18811
9444476 Clostridium ljungdahlii DSM 13528
9486490 Candidatus Nitrospira defluvii
9728858 Streptococcus pneumoniae 670-6B
9773527 Paenibacillus polymyxa E681
9796745 Arthrobacter arilaitensis Re117
9902632 Rothia dentocariosa ATCC 17931
9904419 Gardnerella vaginalis ATCC 14019
10101946 Candidatus Blochmannia vafer str. BVAF
10974211 Zobellia galactanivorans
471 Homo sapiens
396091 Gallus gallus
488513 Canis lupus familiaris
100170854 Sus scrofa
506343 Bos taurus
108147 Mus musculus
81643 Rattus norvegicus
100346623 Oryctolagus cuniculus
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