ATIC Products
(5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC))
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This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009].
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Featured ATIC Categories
ATIC Antibodies
High quality antibodies with extensive validation data.
ATIC Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ATIC Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN7145576
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN6260111
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), ICC
Validations
- (3)
Cat. No.
ABIN2855541
Quantity
100 μL
Datasheet
Datasheet
Recommended ATIC ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6226403
Quantity
96 tests
Datasheet
Datasheet
Recommended ATIC Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345986
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3086774
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3086775
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our ATIC products
: "Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides." in: Journal of proteome research, Vol. 13, Issue 11, pp. 5250-61, (2014) (PubMed).: "5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase." in: The Journal of biological chemistry, Vol. 280, Issue 47, pp. 39582-93, (2005) (PubMed).
: "AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC." in: American journal of human genetics, Vol. 74, Issue 6, pp. 1276-81, (2004) (PubMed).
: "The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate ..." in: The Journal of biological chemistry, Vol. 277, Issue 25, pp. 22168-74, (2002) (PubMed).
Synonyms and alternative names related to ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase L homeolog (atic.L), bifunctional purine biosynthesis protein PurH (purH), bifunctional purine biosynthesis protein purH (purH), Bifunctional purine biosynthesis protein purH (purH), Bifunctional purine biosynthesis protein PurH (purH), 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (Atic), 2610509C24Rik, AA536954, AICAR, AICARFT, AW212393, IMPCHASE, PURH, purHProtein level used designations for ATIC
- bifunctional purine biosynthesis protein PurH
- bifunctional purine biosynthesis protein purH
- Bifunctional purine biosynthesis protein purH
- Bifunctional purine biosynthesis protein PurH
- 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase
- AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme
- AICARFT/IMPCHASE
- bifunctional purine biosynthesis protein PURH
- phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
- 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase, ATIC
- aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase
- aminoimidazole-4-carboxamide ribonucleotidetransformylase/IMP cyclohydrolase
- bifunctional purine biosynthesis protein
Did you look for something else?
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- ATG9A
- ATG7
- ATG5
- ATG4D
- ATG4C
- ATG4B
- ATG4A
- ATG4-2
- ATG3
- ATG2B
- ATG2A
- ATG29
- ATG19
- ATG16L2
- ATG16L1
- ATG14
- ATG13
- ATL1
- ATL2
- ATL3
- Atlastin-2
- ATM
- ATM Interactor
- ATOH1
- ATOH8
- Atonal Homolog 7
- ATOX1
- ATP Synthase Subunit beta
- ATP Synthase Subunit gamma
- ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit E
- ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1A
- ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B
- ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4
- ATP-Binding Cassette, Sub-Family D (Ald), Member 3
- ATP-Binding Protein p29
- ATP-Dependent Clp Protease Proteolytic Subunit 3
- ATP10
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