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ATIC Products

(5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC))

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This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009].

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Featured ATIC Categories

ATIC Antibodies

High quality antibodies with extensive validation data.

ATIC Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ATIC Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7145576
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN6260111
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, IHC (p), ICC
Validations
  • (3)
Cat. No. ABIN2855541
Quantity 100 μL
Datasheet Datasheet

Recommended ATIC ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6226403
Quantity 96 tests
Datasheet Datasheet

Recommended ATIC Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1345986
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3086774
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3128527
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our ATIC products

Genovese, Gualandi, Taddia, Marverti, Pirondi, Marraccini, Perco, Pelà, Guerrini, Amoroso, Esposito, Martello, Ponterini, DArca, Costi: "Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides." in: Journal of proteome research, Vol. 13, Issue 11, pp. 5250-61, (2014) (PubMed).

Rattan, Giri, Singh, Singh: "5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase." in: The Journal of biological chemistry, Vol. 280, Issue 47, pp. 39582-93, (2005) (PubMed).

Marie, Heron, Bitoun, Timmerman, Van Den Berghe, Vincent: "AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC." in: American journal of human genetics, Vol. 74, Issue 6, pp. 1276-81, (2004) (PubMed).

Bulock, Beardsley, Anderson et al.: "The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate ..." in: The Journal of biological chemistry, Vol. 277, Issue 25, pp. 22168-74, (2002) (PubMed).

Synonyms and alternative names related to ATIC

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase L homeolog (atic.L), bifunctional purine biosynthesis protein PurH (purH), bifunctional purine biosynthesis protein purH (purH), Bifunctional purine biosynthesis protein purH (purH), Bifunctional purine biosynthesis protein PurH (purH), 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (Atic), 2610509C24Rik, AA536954, AICAR, AICARFT, AW212393, IMPCHASE, PURH, purH

Protein level used designations for ATIC

  • bifunctional purine biosynthesis protein PurH
  • bifunctional purine biosynthesis protein purH
  • Bifunctional purine biosynthesis protein purH
  • Bifunctional purine biosynthesis protein PurH
  • 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase
  • AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme
  • AICARFT/IMPCHASE
  • bifunctional purine biosynthesis protein PURH
  • phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
  • 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase, ATIC
  • aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase
  • aminoimidazole-4-carboxamide ribonucleotidetransformylase/IMP cyclohydrolase
  • bifunctional purine biosynthesis protein
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