anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) Antibodies

ADAMTS4 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Kits (49) and ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ADAMTS4 240913 Q8BNJ2
ADAMTS4 9507 O75173
ADAMTS4 66015 Q9ESP7
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Top anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Antibodies at antibodies-online.com

Showing 10 out of 170 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-ADAMTS4 Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate Rabbit Anti-ADAMTS4 Antibody  Paraffin Embedded Tissue: Human Kidney Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB <b>Host: </b>Rabbit<br><b>Target Name: </b>Adamts4<br><b>Antibody Dilution: </b>1.0ug/ml<br><b>Sample Tissue: </b>Rat Kidney Host:  Rabbit  Target Name:  Adamts4  Antibody Dilution:  1.0ug/ml  Sample Type:  Rat Kidney 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Western blot analysis of ADAMTS4 using anti-ADAMTS4 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours.   Lane 1: Recombinant Human ADAMTS4 Protein 0.5ng  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-ADAMTS4 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for ADAMTS4 at approximately 58KD. The expected band size for ADAMTS4 is at 53KD. 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-ADAMTS4 Antibody (C-term) (ABIN391642) in mouse cerebellum tissue lysates (35 µg/lane). ADAMTS4 (arrow) was detected using the purified polyclonal antibody. Anti-ADAMTS4 Antibody (C-term) at 1:2000 dilution + Human lung lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 90 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:2000 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated IHC, IHC (p) Anti-ADAMTS4 antibody  ABIN1048289 IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p) Anti-ADAMTS4 antibody  ABIN1048291 IHC staining of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p) Anti-ADAMTS4 antibody  ABIN1048290 IHC staining of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-ADAMTS4 Antibody (C-term) in mouse cerebellum tissue lysates (35ug/lane). ADAMTS4 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Bat Rabbit Un-conjugated IHC, IHC (p) Human Heart (formalin-fixed, paraffin-embedded) stained with ADAMTS4 antibody ABIN625840 at 12 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p) Human Heart (formalin-fixed, paraffin-embedded) stained with ADAMTS4 antibody ABIN290074 at 2.6 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$484.00
Details

ADAMTS4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Antibodies

  1. Cow (Bovine) Polyclonal ADAMTS4 Primary Antibody for IHC, WB - ABIN2776877 : Lee, Hwang, Park, Lee, Park, Kang, Lee, Kim, Park, Park: Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina. in Journal of clinical pathology 2011 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal ADAMTS4 Primary Antibody for WB - ABIN391642 : Tortorella, Pratta, Liu, Abbaszade, Ross, Burn, Arner: The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 Pubmed References

More Antibodies against ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Interaction Partners

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. This study demonstrated that ADAMTS-4 is a new marker of mature oligodendrocytes contributing to the myelination processes and thus to the control of motor capacities.

  2. results demonstrate for the first time that ADAMTS4 contributes to diet induced atherosclerosis in ApoE (show APOE Antibodies)(-/-) mice

  3. the reduction of ADAMTS-4 activity during the progression of ALS pathology may be an adaptive change to mitigate its neurodegenerative impact in CNS tissues

  4. Results show that ADAMTS15 (show ADAMTS15 Antibodies) and ADAMTS4 not only exhibit unique cellular expression patterns in the brain but their developmental upregulation by these cell types coincides with critical aspects of neural development

  5. aggrecan (show ACAN Antibodies) and brevican (show BCAN Antibodies) proteolysis is compensated in Adamts4-/- or Adamts5 (show ADAMTS5 Antibodies)-/- mice by ADAMTS (show ADAMTS1 Antibodies) proteoglycanase (show MMP3 Antibodies) family members but a threshold of versican (show Vcan Antibodies) proteolysis is sensitive to the loss of a single ADAMTS (show ADAMTS1 Antibodies) proteoglycanase (show MMP3 Antibodies) during spinal cord injury

  6. ADAMTS4 has roles in melanoma growth and angiogenesis in mice

  7. The serine protease (show F2 Antibodies) tissue plasminogen activator (tPA (show PLAT Antibodies)) and two matrix metalloproteinases, ADAMTS-4 and ADAMTS-5 (show ADAMTS5 Antibodies), were identified as Reelin (show RELN Antibodies) cleaving enzymes.

  8. ADAMTS-4 cleaves Reelin (show RELN Antibodies) in an isoform-specific manner. Among ADAMTS-4 isoforms, p50 (show LSP1 Antibodies) cleaves the N-t site only, while p75 (show NGFR Antibodies) cleaves both sites.

  9. Data demonstrate that Adamts1 (show ADAMTS1 Antibodies) and Adamts4 play redundant and essential roles in perinatal kidney development.

  10. Drastic down-regulation of Adamts4 observed at both E16 (show SLC7A5 Antibodies) and E18; RT-PCR revealed post-natal reduction in expression (Adamts4, 1/3). Results suggest down-regulation of gene is important factor in normal odontogenesis in dental papillae.

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. ADAMTS4 was associated macrophages infiltration and polarization in the tumor microenvironment of CRC (show CALR Antibodies) and ADAMTS4 knockdown had no inhibitory implications on cell proliferation and invasion in vitro, but significantly attenuated tumor growth in vivo.

  2. ADAMTS4 expression was upregulated during carotid atherosclerotic plaque development. Serum levels of ADAMTS4 were associated with increased plaque vulnerability in both symptomatic and asymptomatic patients with carotid artery stenosis.

  3. methylation status of the ADAMTS4 gene is altered in patellar tendinopathy

  4. HipHop-based pharmacophore modeling and virtual screening of the Maybridge database to identify novel ADAMTS-4 inhibitors. These novel lead compounds act as potent and specific inhibitors for the ADAMTS-4 enzyme and could have therapeutic potential in the treatment of OA.

  5. ADAMTS-4 protein expression increased in cartilage tissue from spinal tuberculosis patients.

  6. Using in vitro approaches and cultured breast cancer cell lines authors demonstrate that Fibulin-2 (show FBLN2 Antibodies) is a better substrate for ADAMTS-5 (show ADAMTS5 Antibodies) than it is for ADAMTS-4. Fibulin-2 (show FBLN2 Antibodies) degradation is associated to an enhancement of the invasive potential of T47D, MCF-7 and SK-BR-3 cells.

  7. ADAMTS4 and ADAMTS15 (show ADAMTS15 Antibodies) were upregulated in symptomatic uterine leiomyomas.

  8. The SNP rs4233367 in the exon of ADAMTS-4 gene may be associated with lumbar disc degeneration.

  9. Single Nucleotide Variants of Candidate Genes in Aggrecan (show ACAN Antibodies) Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes

  10. Results show that ADAMTS4 mRNA is the target of mir (show MLXIP Antibodies)-1268a and its expression might be modified by MIR (show MLXIP Antibodies)-1268a rs28599926 polymorphism in hepatocellular carcinoma.

Cow (Bovine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. ADAMTS4 participates in the regulation of muscle development in cattle.

  2. aggrecanase activity (a) is responsible for early TNFalpha (show TNF Antibodies)-dependent aggrecan (show ACAN Antibodies) cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.

  3. ADAMTS4 and ADAMTS5 (show ADAMTS5 Antibodies) are inhibited by alpha2-macroglobulin (show A2M Antibodies)

  4. identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5 (show ADAMTS5 Antibodies)

ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) Antigen Profile

Protein Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Gene names and symbols associated with ADAMTS4

  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (Adamts4) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif, 4 (Adamts4) antibody
  • ADAMTS like 4 (ADAMTSL4) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif 4 (Adamts4) antibody
  • 3830423K05 antibody
  • ADAM-TS4 antibody
  • ADAMTS-2 antibody
  • ADAMTS-4 antibody
  • ADAMTS4 antibody
  • ADMP-1 antibody
  • mKIAA0688 antibody

Protein level used designations for ADAMTS4

A disintegrin and metalloproteinase with thrombospondin motifs 4 , ADAM-TS 4 , ADAMTS-4 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 , aggrecanase-1 , ADAM-TS4 , Aggrecanase , a disintegrin and metallopeptidase with thrombospondin motifs 4 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 , ADMP-1 , ADAM metallopeptidase with thrombospondin type 1 motif, 4 , A disintegrin and metalloproteinase with thrombospondin motifs 4-like , disintegrin and metalloproteinase with thrombospondin motifs 2 , a disintegrin and metalloproteinase with thrombospondin motifs 4

GENE ID SPECIES
240913 Mus musculus
9507 Homo sapiens
66015 Rattus norvegicus
286806 Bos taurus
457453 Pan troglodytes
488651 Canis lupus familiaris
719927 Macaca mulatta
100033914 Equus caballus
100409334 Callithrix jacchus
100008765 Oryctolagus cuniculus
100482466 Ailuropoda melanoleuca
100606067 Nomascus leucogenys
100514576 Sus scrofa
100712995 Cavia porcellus
101106565 Ovis aries
100461178 Pongo abelii
100858999 Gallus gallus
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