anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) Antibodies

ADAMTS4 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Kits (44) and ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ADAMTS4 240913 Q8BNJ2
ADAMTS4 9507 O75173
ADAMTS4 66015 Q9ESP7
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Antibodies at antibodies-online.com

Showing 10 out of 152 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Anti-ADAMTS4 antibody, Western blotting Lane 1: Rat Brain Tissue Lysate Lane 2: Mouse Brain Tissue Lysate 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Western blot analysis of ADAMTS4 using anti-ADAMTS4 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours.   Lane 1: Recombinant Human ADAMTS4 Protein 0.5ng  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-ADAMTS4 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for ADAMTS4 at approximately 58KD. The expected band size for ADAMTS4 is at 53KD. 100 μg Log in to see 4 to 6 Days
$280.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-ADAMTS4 Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate Rabbit Anti-ADAMTS4 Antibody  Paraffin Embedded Tissue: Human Kidney Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Host: RabbitTarget Name: Adamts4Antibody Dilution: 1.0ug/mlSample Tissue: Rat Kidney Host:  Rabbit  Target Name:  Adamts4  Antibody Dilution:  1.0ug/ml  Sample Type:  Rat Kidney 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-ADAMTS4 Antibody (C-term) (ABIN391642) in mouse cerebellum tissue lysates (35 µg/lane). ADAMTS4 (arrow) was detected using the purified polyclonal antibody. Anti-ADAMTS4 Antibody (C-term) at 1:2000 dilution + Human lung lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 90 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:2000 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Anti-ADAMTS4 antibody  ABIN1048289 IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-ADAMTS4 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p) Anti-ADAMTS4 antibody  ABIN1048290 IHC staining of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-ADAMTS4 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p) Anti-ADAMTS4 antibody  ABIN1048291 IHC staining of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-ADAMTS4 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of extracts of hela cell line, using ADAMTS4 antibody,the lane on the left is blocked by antigen peptide. ABIN6277245 at 1/100 staining Mouse brain tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-ADAMTS4 Antibody (C-term) in mouse cerebellum tissue lysates (35ug/lane). ADAMTS4 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details

Top referenced anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Antibodies

  1. Cow (Bovine) Polyclonal ADAMTS4 Primary Antibody for IHC, WB - ABIN2776877 : Lee, Hwang, Park, Lee, Park, Kang, Lee, Kim, Park, Park: Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina. in Journal of clinical pathology 2011 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal ADAMTS4 Primary Antibody for ELISA, IHC (p) - ABIN5518725 : Chen, Bai, Liao, Peng, Wu, Wang, Zeng, Xie: Electrospun poly(L-lactide)/poly(?-caprolactone) blend nanofibrous scaffold: characterization and biocompatibility with human adipose-derived stem cells. in PLoS ONE 2013 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal ADAMTS4 Primary Antibody for WB - ABIN3043192 : Liu, Tian, Zhou, Wang, Gou, Zhang, Wang, Shen, Zhang, Zhang: Protective effect of calcitonin on lumbar fusion-induced adjacent-segment disc degeneration in ovariectomized rat. in BMC musculoskeletal disorders 2016 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal ADAMTS4 Primary Antibody for WB - ABIN391642 : Tortorella, Pratta, Liu, Abbaszade, Ross, Burn, Arner: The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal ADAMTS4 Primary Antibody for ELISA, IHC - ABIN6259788 : Zhou, Lu, Chen, Ge, Chen, Xu, Shi, Dai, Li, Ju, Cao, Qin, Chen, Teng, Jiang: AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice. in Scientific reports 2017 (PubMed)

More Antibodies against ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Interaction Partners

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclampsia group.

  2. ADAMTS4 was associated macrophages infiltration and polarization in the tumor microenvironment of CRC and ADAMTS4 knockdown had no inhibitory implications on cell proliferation and invasion in vitro, but significantly attenuated tumor growth in vivo.

  3. ADAMTS4 expression was upregulated during carotid atherosclerotic plaque development. Serum levels of ADAMTS4 were associated with increased plaque vulnerability in both symptomatic and asymptomatic patients with carotid artery stenosis.

  4. methylation status of the ADAMTS4 gene is altered in patellar tendinopathy

  5. HipHop-based pharmacophore modeling and virtual screening of the Maybridge database to identify novel ADAMTS-4 inhibitors. These novel lead compounds act as potent and specific inhibitors for the ADAMTS-4 enzyme and could have therapeutic potential in the treatment of OA.

  6. ADAMTS-4 protein expression increased in cartilage tissue from spinal tuberculosis patients.

  7. Using in vitro approaches and cultured breast cancer cell lines authors demonstrate that Fibulin-2 is a better substrate for ADAMTS-5 than it is for ADAMTS-4. Fibulin-2 degradation is associated to an enhancement of the invasive potential of T47D, MCF-7 and SK-BR-3 cells.

  8. ADAMTS4 and ADAMTS15 were upregulated in symptomatic uterine leiomyomas.

  9. The SNP rs4233367 in the exon of ADAMTS-4 gene may be associated with lumbar disc degeneration.

  10. Single Nucleotide Variants of Candidate Genes in Aggrecan Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes

  11. Results show that ADAMTS4 mRNA is the target of mir-1268a and its expression might be modified by MIR-1268a rs28599926 polymorphism in hepatocellular carcinoma.

  12. we investigated whether important polymorphisms in the ADAMTS4 and ADAMTS5 genes affect osteoarthritis (OA) susceptibility. ADAMTS4 and ADAMTS5 genotypes were determined using the ABI Prism StepOnePlus Real-Time system. Our findings suggest that the ADAMTS4 (rs4233367 and rs11807350) and ADAMTS5 (rs226794 and rs2830585) variants examined may not contribute to susceptibility to knee OA in the Turkish population.

  13. ADAMTS4 expression is significantly upregulated in human masticatory mucosa during wound healing

  14. ADAMTS4 may have a role in the pathogenesis by causing increased oxidative and inflammatory environment in preterm premature rupture of membranes .

  15. in degenerative intervertebral discs, IL1b upregulates NFkB, MMP13 and ADAMTS4

  16. progesterone acts via the progesterone receptor to modulate ADAMTS 1 and 4 levels in ovarian cancer cell lines.

  17. ADAMTS4 may be responsible for the pathogenesis of atherosclerosis. ADAMTS4 serum levels were also higher in diabetic cases. There is an association between ADAMTS4 and TGFb1 serum levels in the progression of atherosclerosis in coronary artery disease.

  18. Evaluate ADAMTS-4 and ADAMTS-5 immunohistochemical expression in human TMJ discs from patients affected by internal derangement.

  19. These data demonstrate that the antibody is specific to ADAMTS4 and ADAMTS5 and inhibits their aggrecanase activity at molecular and cellular levels.

  20. ADAMTS4 is largely associated with synapses, and is the main brevican-processing protease.

Cow (Bovine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. ADAMTS4 participates in the regulation of muscle development in cattle.

  2. aggrecanase activity (a) is responsible for early TNFalpha-dependent aggrecan cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.

  3. ADAMTS4 and ADAMTS5 are inhibited by alpha2-macroglobulin

  4. identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5

ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) Antigen Profile

Protein Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Gene names and symbols associated with ADAMTS4

  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (Adamts4) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif, 4 (Adamts4) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif 4 (Adamts4) antibody
  • 3830423K05 antibody
  • ADAM-TS4 antibody
  • ADAMTS-2 antibody
  • ADAMTS-4 antibody
  • ADAMTS4 antibody
  • ADMP-1 antibody
  • mKIAA0688 antibody

Protein level used designations for ADAMTS4

A disintegrin and metalloproteinase with thrombospondin motifs 4 , ADAM-TS 4 , ADAMTS-4 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 , aggrecanase-1 , ADAM-TS4 , Aggrecanase , a disintegrin and metallopeptidase with thrombospondin motifs 4 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 , ADMP-1 , ADAM metallopeptidase with thrombospondin type 1 motif, 4 , A disintegrin and metalloproteinase with thrombospondin motifs 4-like , disintegrin and metalloproteinase with thrombospondin motifs 2 , a disintegrin and metalloproteinase with thrombospondin motifs 4

GENE ID SPECIES
240913 Mus musculus
9507 Homo sapiens
66015 Rattus norvegicus
286806 Bos taurus
457453 Pan troglodytes
488651 Canis lupus familiaris
719927 Macaca mulatta
100033914 Equus caballus
100409334 Callithrix jacchus
100008765 Oryctolagus cuniculus
100482466 Ailuropoda melanoleuca
100606067 Nomascus leucogenys
100712995 Cavia porcellus
101106565 Ovis aries
100461178 Pongo abelii
100858999 Gallus gallus
Selected quality suppliers for anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) Antibodies
Did you look for something else?