ADAMTS4 antibody

Catalog No. ABIN7072947

Product Details anti-ADAMTS4 Antibody

Target: ADAMTS4 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAMTS4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse ADAMTS4

Application Details

Application Notes: IHC/IF (M,R) 1:500-1:3000/1:250-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for ADAMTS4

Target: ADAMTS4 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4))

Alternative Name: ADAMTS4 (ADAMTS4 Products)

Synonyms: 3830423K05 antibody, ADAM-TS4 antibody, ADAMTS-2 antibody, ADMP-1 antibody, mKIAA0688 antibody, ADAMTS-4 antibody, ADAMTS4 antibody, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 antibody, ADAM metallopeptidase with thrombospondin type 1 motif 4 antibody, ADAM metallopeptidase with thrombospondin type 1 motif, 4 antibody, Adamts4 antibody, ADAMTS4 antibody

Background: A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme encoded by the ADAMTS4 gene. ADAMTS4 is the shortest known ADAMTS, lacking the C-terminal domain and is the only non-glycosylated ADAMTS. This protein cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. The protein may play an important role in the destruction of aggrecan in arthritic diseases. It could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease.

Gene ID: 240913

NCBI Accession: NP_766433

UniProt: Q8BNJ2