anti-APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) Antibodies

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. Additionally we are shipping APEX2 Kits (4) and APEX2 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
APEX2 27301 Q9UBZ4
APEX2 77622 Q68G58
APEX2 317628  
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Top anti-APEX2 Antibodies at antibodies-online.com

Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Anti- APEX2 antibody, Western blotting All lanes: Anti APEX2  at 0.5ug/ml WB: SMMC Whole Cell Lysate at 40ug Predicted bind size: 57KD Observed bind size: 57KD Anti- APEX2 antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of APEX2 Antibody (Center) (ABIN652924) in MCF-7 cell line lysates (35 µg/lane). APEX2 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma reacted with APEX2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Cow Rabbit Un-conjugated IHC, IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-APEX2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μL Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IF, WB Immunocytochemistry/Immunofluorescence: APEX2 Antibody  - Staining of human cell line U-2 OS shows localization to nucleus, nucleoli fibrillar center & vesicles. Western Blot: APEX2 Antibody  - Western blot analysis in human cell line RT-4, human cell line U-251 MG, human plasma and human liver tissue. 100 μL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μL Log in to see 6 to 8 Days
$495.00
Details
Human Rabbit Un-conjugated WB Western Blot: APEX2 Antibody [ABIN42810615] - Western blot analysis of APEXL2 in HeLa cell lysates using ABIN42810615 at a dilution of 1:500. 0.2 mL Log in to see 7 to 9 Days
$347.48
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western Blot at 1:1000 dilution + MCF-7 whole cell lysate Lysates/proteins at 20 ug per lane. Immunofluorescent analysis of U251 cells, using APEX2 Antibody . Antibody was diluted at 1:25 dilution. Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). Cytoplasmic actin was counterstained with Dylight Fluor 554 (red) conjugated Phalloidin (red). 400 μL Log in to see 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-APEX2 Polyclonal Antibody, Unconjugated (ABIN718481) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$317.90
Details
Cow Rabbit Un-conjugated IHC, IHC (p), WB   100 μg Log in to see 11 to 14 Days
$537.17
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$416.90
Details

Top referenced anti-APEX2 Antibodies

  1. Human Polyclonal APEX2 Primary Antibody for WB - ABIN4281061 : Karkhanis, Wang, Tae, Hu, Imbalzano, Sif: Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1. in The Journal of biological chemistry 2012 (PubMed)

  2. Human Polyclonal APEX2 Primary Antibody for ICC, IF - ABIN5075036 : Mengwasser, Adeyemi, Leng, Choi, Clairmont, DAndrea, Elledge: Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. in Molecular cell 2019 (PubMed)

More Antibodies against APEX2 Interaction Partners

Human APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2.

  2. Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III

  3. Ape2 exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity.

  4. Ape2 may be involved in repair of oxidative DNA damage and PCNA-dependent repair synthesis.

  5. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.

Xenopus laevis APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. APE2 associates with Chk1; a serine residue (S86) in the Chk1-binding motif of APE2 is essential for Chk1 phosphorylation, indicating a Claspin-like but distinct role for APE2 in ATR-Chk1 signaling.

Mouse (Murine) APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. expression of Apex 2 in chondrocytes appears to be associated with the degeneration of articular cartilage in osteoarthritis.

  2. Results indicate a role for apurinic/apyrimidinic endonuclease (APE) 2 (Apex2) in the protection of germinal center (GC) cells from activation-induced cytidine deaminase (AID)-independent damage.

  3. data provide new insight into error-prone repair of AID-induced lesions, which we propose is facilitated by down-regulation of APE1 and up-regulation of APE2 expression in germinal center B cells.

  4. Extensive analysis of bone marrow hematopoiesis in APE2-deficient mice finds inhibition of the pro-B to pre-B lymphocyte transition, due to a p53-dependent DNA damage response, independent from its ubiquitous and essential homolog APE1.

  5. may participate in postreplicative base excision repair

  6. APEX2 is required for proper cell cycle progression of proliferating lymphocytes.

  7. Both APE1 and APE2 function in antibody switch recomibination, resulting in double stranded breaks necesary for this recombination.

  8. The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair.

  9. Apex2 is required for efficient somatic hypermutation of immunoglobulin genes.

APEX2 Antigen Profile

Protein Summary

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with APEX2

  • apurinic/apyrimidinic endodeoxyribonuclease 2 (APEX2) antibody
  • apurinic/apyrimidinic endodeoxyribonuclease 2 (apex2) antibody
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (apex2) antibody
  • apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog (apex2.L) antibody
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (APEX2) antibody
  • apurinic/apyrimidinic endonuclease 2 (Apex2) antibody
  • apurinic/apyrimidinic endodeoxyribonuclease 2 (Apex2) antibody
  • ape2 antibody
  • apexl2 antibody
  • C430040P13Rik antibody
  • xth2 antibody
  • zgc:55889 antibody

Protein level used designations for APEX2

AP endonuclease 2 , AP endonuclease XTH2 , DNA-(apurinic or apyrimidinic site) lyase 2 , apurinic/apyrimidinic endonuclease-like 2 , APEX nuclease 2 , apurinic-apyrimidinic endonuclease 2 , APEX nuclease (apurinic/apyrimidinic endonuclease) 2 , DNA-(apurinic or apyrimidinic site) lyase 2-like

GENE ID SPECIES
27301 Homo sapiens
448512 Xenopus (Silurana) tropicalis
393115 Danio rerio
446614 Xenopus laevis
491499 Canis lupus familiaris
511790 Bos taurus
702084 Macaca mulatta
100410557 Callithrix jacchus
100434759 Pongo abelii
77622 Mus musculus
317628 Rattus norvegicus
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