APEX2 Products
(APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))
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Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012].
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Featured APEX2 Categories
APEX2 Antibodies
High quality antibodies with extensive validation data.
APEX2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended APEX2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, FACS, IHC (p)
Validations
- (4)
Cat. No.
ABIN652924
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN525954
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, FACS, IF/ICC
Validations
- (3)
Cat. No.
ABIN3003990
Quantity
400 μL
Datasheet
Datasheet
Recommended APEX2 ELISA Kits
Recommended APEX2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3089223
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3135636
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2714790
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our APEX2 products
: "Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets." in: Molecular cell, Vol. 73, Issue 5, pp. 885-899.e6, (2019) (PubMed).: "Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1." in: The Journal of biological chemistry, Vol. 287, Issue 35, pp. 29801-14, (2012) (PubMed).
: "Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen." in: Nucleic acids research, Vol. 29, Issue 11, pp. 2349-60, (2001) (PubMed).
Synonyms and alternative names related to APEX2
apurinic/apyrimidinic endodeoxyribonuclease 2 (APEX2), apurinic/apyrimidinic endodeoxyribonuclease 2 (apex2), APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (apex2), apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog (apex2.L), APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (APEX2), apurinic/apyrimidinic endonuclease 2 (Apex2), apurinic/apyrimidinic endodeoxyribonuclease 2 (Apex2), APE2, ape2, APEXL2, apexl2, C430040P13Rik, XTH2, xth2, zgc:55889Protein level used designations for APEX2
- AP endonuclease 2
- AP endonuclease XTH2
- DNA-(apurinic or apyrimidinic site) lyase 2
- apurinic/apyrimidinic endonuclease-like 2
- APEX nuclease 2
- apurinic-apyrimidinic endonuclease 2
- APEX nuclease (apurinic/apyrimidinic endonuclease) 2
- DNA-(apurinic or apyrimidinic site) lyase 2-like
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