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Plays an important role in the functional organization of mitotic chromosomes (By similarity). Additionally we are shipping ARP8 Actin-Related Protein 8 Homolog (Yeast) Kits (12) and ARP8 Actin-Related Protein 8 Homolog (Yeast) Proteins (7) and many more products for this protein.
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These findings provide the first insight into the possible contributions of plant ARP8 to nucleolar functions.
Plays a regulatory role in the binding of Arp8 to DNA.
Binding studies reveal that Arp8 and the Arp8-Arp4-actin-HSA sub-complex of INO80 strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting that Arp8 functions as a nucleosome recognition module.
These results suggest that ARP8 is required for the recruitment of the mammalian INO80 complex to the laser-induced DNA damage sites.
Expression of truncated hArp8 proteins and depletion of endogenous hArp8 by RNA interference caused misalignment of mitotic chromosomes, suggesting that chromosome-associated hArp8 has a role in chromosome behavior.
Plays an important role in the functional organization of mitotic chromosomes (By similarity). Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage (By similarity).
, actin-related protein 8
, ARP8 actin-related protein 8 homolog
, actin-related protein 8 homolog
, INO80 complex subunit N