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ASF1A encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. Additionally we are shipping ASF1A Proteins (12) and many more products for this protein.
Showing 10 out of 138 products:
Human Polyclonal ASF1A Primary Antibody for ELISA, WB - ABIN4281853
Sanematsu, Takami, Barman, Fukagawa, Ono, Shibahara, Nakayama: Asf1 is required for viability and chromatin assembly during DNA replication in vertebrate cells. in The Journal of biological chemistry 2006
ASF1A is aberrantly over-expressed in GIC tumors and plays key roles in GIC development and progression by stimulating the transcription of beta-catenin (show CTNNB1 Antibodies) target genes.
ASF1a promotes non-homologous end joining repair by facilitating phosphorylation of MDC1 (show MDC1 Antibodies) by ATM (show ATM Antibodies) at double-strand breaks.
These data suggest that CAF-1 (show CHAF1B Antibodies)- and ASF1A-H3-H4-dependent deposition of the histone (H3 (show HIST3H3 Antibodies)-H4)2 tetramers is compatible with MMR (show MRC1 Antibodies) and protects the discontinuous daughter strand from unnecessary degradation by MMR (show MRC1 Antibodies) machinery.
Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation.
quaternary complex of histone H3 (show HIST3H3 Antibodies)-H4 heterodimer with chaperone ASF1 (show SRSF1 Antibodies) and the replicative helicase subunit MCM2 (show MCM2 Antibodies)
Thermodynamic analysis of the quaternary complex together with structural modeling support that ASF1 (show SRSF1 Antibodies) and MCM2 (show MCM2 Antibodies) could form a chaperoning module for histones H3 and H4 protecting them from promiscuous interactions.
Data indicate Tousled-like kinases (TLK1 (show TLK1 Antibodies)) phosphorylation has an impact on cell cycle proteins Asf1a and Asf1b (show ASF1B Antibodies) function.
findings show that ASF1A, a histone-remodeling chaperone specifically enriched in the metaphase II oocyte, is necessary for reprogramming of adult dermal fibroblasts into undifferentiated induced pluripotent stem cell
The ATR (show ANTXR1 Antibodies) checkpoint pathway causes a histone chaperone normally associated with the replication fork, ASF1a, to degrade through a CRL1 (show IL27RA Antibodies)(betaTRCP (show BTRC Antibodies))-dependent ubiquitination/proteasome pathway, leading to the localized dechromatinization and gene repression.
Co-depletion of the histone chaperones ASF1a and ASF1b (show ASF1B Antibodies) in human cells induces all hallmarks of alternative lengthening of telomeres in both primary and cancer cells.
tousled-like kinases play important roles in DNA repair, not only by modulation of chromatin assembly via Asf1 (show PEG3 Antibodies), but also by a more direct function in processing the ends of a tousled-like kinase via interaction with Rad9 (show RAD9A Antibodies).
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair.
ASF1 anti-silencing function 1 homolog A
, CCG1-interacting factor A
, anti-silencing function protein 1 homolog A
, histone chaperone ASF1A
, anti-silencing function 1
, anti-silencing function protein 1 homolog
, histone chaperone ASF1
, ASF1 anti-silencing function 1-like protein A
, histone chaperone ASF1A-like
, Anti-silencing function protein 1 homolog
, Anti-silencing function protein 1 homolog A-A
, anti-silencing function protein 1 homolog A-A
, anti-silencing function protein 1-A
, chromatin assembly factor
, histone chaperone asf1-A
, histone chaperone asf1a-A