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The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antibodies (290) and ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteins (7) and many more products for this protein.
Showing 10 out of 28 products:
ABCB1 gene polymorphisms are not associated with response to chemotherapy in breast cancer.
Patients prescribed with short-term low-dose atorvastatin and carrying ABCB1 (rs1128503) or ABCG2 (rs2231142) SNPs did not show differences in LDL-C response (P>.05).
Genotypes of UGT1A (show UGT1A1 ELISA Kits) and ABCB1 were significantly associated with changes in moxifloxacin pharmacokinetic parameters.
G2677T/A polymorphism of MDR1 may play a significant role in the development of drug-resistant epilepsy in the Polish patients
No association was found between the ABCB1 SNPs and Crohn's disease in the two populations
icaritin (ICT) decreased the mRNA and protein levels of multidrug resistance protein 1 (MDR1 (show ABCB4 ELISA Kits)) in MG-63 doxorubicin-resistant (MG-63/DOX) cells.
We demonstrate for the first time that the effect of ABCB1 diplotype on tacrolimus disposition is dependent on both CYP3A5 (show CYP3A5 ELISA Kits) and CYP3A4 (show CYP3A4 ELISA Kits) genotype.
these results address key concerns in the field, including that of cross-resistance between taxanes and highlighting a mechanism of cabazitaxel resistance involving ABCB1
CYP3A (show CYP3A4 ELISA Kits) and ABCB1 SNPs were detected in 521 recipients.
MDR-1 C3435T gene polymorphism was associated with right ventricular dysfunction in patients with chronic obstructive pulmonary disease.
P-gp (show ABCB4 ELISA Kits), Bcrp and Mrp1 (show ABCC1 ELISA Kits) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.
This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.
Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance
ABCB1 is expressed in bovine oocytes and embryos.
A panel of 18 P-gp (show ABCB4 ELISA Kits) substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a (show ABCB4 ELISA Kits)/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp (show ABCB4 ELISA Kits) can affect the pulmonary kinetics of a subset of P-gp (show ABCB4 ELISA Kits) substrates.
Data suggest that the overexpression of P-gp (show ABCB4 ELISA Kits) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.
We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.
Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (show ABCB4 ELISA Kits), multi-drug resistance protein, MDR1 (show ABCB4 ELISA Kits)).Drugs with ER < 1 almost do not bind the main binding cavity (MBC (show CACNA1C ELISA Kits)) of P-gp (show ABCB4 ELISA Kits).
conclusion, MDR1 (show ABCB4 ELISA Kits) and BCRP are expressed on apical membranes of the rodent placental SynT (show STX1A ELISA Kits)-II layer.
Mdr1 (show ABCB4 ELISA Kits) enforces T Cell homeostasis in the presence of intestinal bile acids.
Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp (show ABCB4 ELISA Kits) ATPase (show DNAH8 ELISA Kits) activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
Chrysosplenetin inhibited P-gp (show ABCB4 ELISA Kits) activity and reverse the up-regulated P-gp (show ABCB4 ELISA Kits) and MDR1 (show ABCB4 ELISA Kits) levels induced by artemisinin.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette, sub-family B (MDR/TAP), member 1
, ATP-binding cassette, subfamily B (MDR/TAP), member 1A
, multiple drug resistant 1a
, bovine P-glycoprotein
, ATP-binding cassette, subfamily B, member 1
, multidrug resistance p-glycoprotein
, multidrug resistance protein
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B