Acetyl-CoA Acetyltransferase 1 Proteins (ACAT1)

ACAT1 encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Additionally we are shipping ACAT1 Antibodies (164) and ACAT1 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACAT1 38 P24752
ACAT1 25014 P17764
ACAT1 110446 Q8QZT1
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Top ACAT1 Proteins at

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
Yeast Xenopus tropicalis His tag   1 mg Log in to see 60 to 71 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Yeast Cynomolgus His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days

ACAT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus)

Mouse (Murine) ,

More Proteins for Acetyl-CoA Acetyltransferase 1 (ACAT1) Interaction Partners

Human Acetyl-CoA Acetyltransferase 1 (ACAT1) interaction partners

  1. Intracranial GBM xenografts were used to determine the effects of genetically silencing SOAT1 (show SOAT1 Proteins) and SREBP-1 (show SREBF1 Proteins) on tumor growth.

  2. Our results demonstrated the contrasting effects of STC1 (show STC1 Proteins) and STC2 (show STC2 Proteins)-derived peptides on human macrophage foam cell formation associated with ACAT1 expression and on HASMC migration.

  3. Higher Gleason grade was associated with lower LDLR (show LDLR Proteins) expression, lower SOAT1 (show SOAT1 Proteins) and higher SQLE (show SQLE Proteins) expression. Besides high SQLE (show SQLE Proteins) expression, cancers that became lethal despite primary treatment were characterized by low LDLR (show LDLR Proteins) expression (odds ratio for highest versus lowest quintile, 0.37; 95% CI 0.18-0.76) and by low SOAT1 (show SOAT1 Proteins) expression (odds ratio, 0.41; 95% CI 0.21-0.83).

  4. these results illustrate that ACAT1-catalyzed esterification of 24S-OHC with long-chain unsaturated fatty acid followed by formation of atypical LD-like structures at the ER membrane is a critical requirement for 24S-OHC-induced cell death.

  5. ACAT1 exonic mutations that affect ESE sequences may result in aberrant splicing. This may affect the activity of mitochondrial acetoacetyl-CoA thiolase.

  6. TLR4 (show TLR4 Proteins) siRNA inhibits cell proliferation, migration and invasion by suppressing ACAT1 expression, suggesting that TLR4 (show TLR4 Proteins) may be a potential therapeutic target for the treatment of colorectal cancer

  7. ACAT1 has a role in regulating the dynamics of free cholesterols in plasma membrane which leads to the APP (show APP Proteins)-alpha-processing alteration

  8. compound heterozygous of ACAT1 gene mutations probably underlie the beta-ketothiolase deficiency in our patient

  9. ACAT1 regulates glioblastoma-cell proliferation via modification of the Akt and/or the ERK1/2 pathway.

  10. Data indicate that mitotane confers adrenal-specific cytotoxicity and down-regulates steroidogenesis by inhibition of sterol-O-acyl-transferase 1 (SOAT1 (show SOAT1 Proteins)) leading to lipid-induced endoplasmic reticulum (ER) stress.

Mouse (Murine) Acetyl-CoA Acetyltransferase 1 (ACAT1) interaction partners

  1. Data show that microRNA miR (show MLXIP Proteins)-467b regulates the acetyl-CoA acetyltransferase 1 (ACAT1) expression via targeting ACAT1 (show SOAT1 Proteins) 3' untranslated regions (3'UTR).

  2. In a mouse model, targeting ACAT1 (show SOAT1 Proteins) specifically in a myeloid lineage may benefit atherosclerosis progression by reducing the infiltration of foamy macrophages.

  3. Oxidized low-density lipoprotein activated the TLR4 (show TLR4 Proteins)/MyD88 (show MYD88 Proteins)/NF-kappaB (show NFKB1 Proteins) inflammatory signaling pathway in vascular smooth muscle cell, which upregulates the ACAT1 (show SOAT1 Proteins) expression and promotes VSMC foam cell formation.

  4. Exacerbation of liver fibrosis by ACAT1 (show SOAT1 Proteins) deficiency was dependent on free cholesterol accumulation-induced enhancement of TLR4 (show TLR4 Proteins) signaling.

  5. ACAT1 (show SOAT1 Proteins) plays important roles in hematopoiesis in normal mouse and in Apoe (show APOE Proteins)(-/-) mouse during atherosclerosis development.

  6. ApoA-I (show APOA1 Proteins) Helsinki promotes accumulation of ACAT1 (show SOAT1 Proteins) in a mouse macrophage cell line.

  7. the plaque-modulating effects of K-604 can be explained by stimulation of procollagen production independent of ACAT (show SOAT1 Proteins) inhibition in addition to potent inhibition of macrophage ACAT-1 (show SOAT1 Proteins)

  8. ACAT1 (show SOAT1 Proteins) gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with Alzheimer disease.

  9. ACAT1 displays less capacity than ACAT2 to differentiate cholesterol from sitosterol

  10. ACAT1 (show SOAT1 Proteins) knockout macrophages show biochemical changes consistent with increased cytotoxicity and also a novel association with decreased expression of collagen type 3A1.

Cow (Bovine) Acetyl-CoA Acetyltransferase 1 (ACAT1) interaction partners

  1. The transcript abundance of ACAT1 was increased in the more efficient low residual feed intake (RFI (show RNF34 Proteins)) animals and decreased in the less efficient high RFI (show RNF34 Proteins) animals

ACAT1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with ACAT1

  • acetyl-CoA acetyltransferase 1 (ACAT1)
  • sterol O-acyltransferase 1 (SOAT1)
  • acetyl-CoA acetyltransferase 1 (Acat1)
  • acetyl-Coenzyme A acetyltransferase 1 (Acat1)
  • acetyl-CoA acetyltransferase 1 (acat1)
  • acetyl-CoA acetyltransferase 1 L homeolog (acat1.L)
  • 6330585C21Rik protein
  • ACACT protein
  • Acat protein
  • ACAT-1 protein
  • ACAT1 protein
  • acat1-a protein
  • fd16h07 protein
  • fd20g06 protein
  • MAT protein
  • RATACAL protein
  • SOAT protein
  • STAT protein
  • T2 protein
  • THIL protein
  • wu:fd16h07 protein
  • wu:fd20g06 protein
  • zgc:86832 protein

Protein level used designations for ACAT1

acetoacetyl Coenzyme A thiolase , acetoacetyl-CoA thiolase , acetyl-CoA acetyltransferase, mitochondrial , acetyl-Coenzyme A acetyltransferase 1 , mitochondrial acetoacetyl-CoA thiolase , acyl-coenzyme A:cholesterol acyltransferase 1 , sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 , acetyl-Co A acetyltransferase 1 mitochondrial , acetyl-coenzyme A acetyltransferase 1 , acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) , acetyl-CoA acetyltransferase 1 , Acetoacetyl-CoA thiolase A , acetyl-CoA acetyltransferase A, mitochondrial

38 Homo sapiens
6646 Homo sapiens
25014 Rattus norvegicus
110446 Mus musculus
418968 Gallus gallus
445290 Danio rerio
489421 Canis lupus familiaris
511082 Bos taurus
100597123 Nomascus leucogenys
100626793 Sus scrofa
414639 Xenopus laevis
100717423 Cavia porcellus
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