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ACVR1B encodes an activin A type IB receptor. Additionally we are shipping Activin A Receptor Type IB Antibodies (158) and Activin A Receptor Type IB Kits (8) and many more products for this protein.
Showing 10 out of 29 products:
Our study provided experimental and clinical evidence for the involvement of activin A (show INHBA Proteins) and ALK4 in the pathophysiology of atrial fibrosis and atrial fibrillation
Our results demonstrate that ALK4 haploinsufficiency ameliorates cardiac fibrosis and dysfunction in a mouse pressure-overload model associated with inhibition of cardiac fibroblast activation and cardiomyocyte apoptosis through the suppression of Smad2 (show SMAD2 Proteins)/3 activity.
ALK4 is an important profibrotic signaling molecule in the post-MI CF. Haplodeficiency of ALK4 significantly improved LV function and survival rate by attenuating CF in vivo, ameliorated
Uterine Activin-Like Kinase 4 Regulates Trophoblast Development During Mouse Placentation
These results indicate that an appropriate level of activin signaling may be required for GSIS in pancreatic beta cells, and that activin signaling involves modulation of KATP channel activity.
Signaling through the TGF beta (show TGFB1 Proteins)-activin receptors ALK4/5/7 regulates testis formation and male germ cell development.
identified ACVRIB as a direct target of miR (show MLXIP Proteins)-145. The ectopic expression of miR (show MLXIP Proteins)-145 reduced the levels of both ACVRIB mRNA and protein and also interfered with activin-induced Smad2 (show SMAD2 Proteins) phosphorylation.
Results identify a molecular mechanism that explains the cell-type specific aspects of signaling by myostatin (show MSTN Proteins), ALK4, ALK5 (show TGFBR1 Proteins), and other TGF-beta (show TGFB1 Proteins) family members.
Inhibin alpha-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling.
Knockdown or pharmacological inhibition of the Nodal/Activin receptor Alk4/7 in cancer stem cells virtually abrogated their self-renewal capacity and in vivo tumorigenicity
Overexpression of ALK4 suppressed glioma cell proliferation, migration and invasion through the inactivation of JAK (show JAK3 Proteins)/STAT3 (show STAT3 Proteins) signaling pathway.
Results showed that ACVR1B expression is upregulated during latent infection with a miR (show MLXIP Proteins)-UL148D deletion virus. Data indicates miR (show MLXIP Proteins)-UL148D inhibits ACVR1B expression in latently infected cells to limit proinflammatory cytokine secretion.
It was concluded that ALK4 inhibition increases myogenesis but also regulates the tight balance of protein synthesis and degradation.
in a relatively large cohort of athletes from Europe and South America we have shown that the ACVR1B rs2854464 A allele is associated with sprint/power performance in Caucasians but not in Brazilian athletes.
ALK4 is expressed in male germ cells and Sertoli cells.
This study demonstrated positive regulation of monocyte/macrophage differentiation by lnc-MC and uncovered an elaborate regulation mechanism composed of PU.1, lnc-MC, miR (show MLXIP Proteins)-199a-5p, and ACVR1B.
Data suggest that activin A (show INHBA Proteins) up-regulates SNAIL (show SNAI1 Proteins) expression via ALK4/ACVR1B-induced SMAD (show SMAD1 Proteins) signaling in trophoblast cells; elevated SNAIL (show SNAI1 Proteins) contributes to up-regulation of MMP2 (show MMP2 Proteins) expression which plays key role in promoting trophoblast cell invasion.
ACVR1B functions as a positive regulator of monocyte/macrophage differentiation. ACVR1B knockdown promoted THP-1 proliferation by increasing Rb phosphorylation. Down-regulation reduced p-Smad2 (show SMAD2 Proteins)/3 and C/EBPalpha (show CEBPA Proteins), inhibiting monocyte/macrophage differentiation.
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.
activin A receptor, type IB
, activin A receptor, type 1B
, activin type IB receptor
, activin receptor type-1B-like
, Activin receptor type-1B
, activin receptor IB
, activin receptor type IB
, activin receptor type-1B
, activin receptor-like kinase 4
, serine/threonine-protein kinase receptor R2
, activin A receptor, type II-like kinase 4
, Serine/threonine-protein kinase receptor R2