Activin A Receptor Type IB/ALK-4 Protein (Fc Tag,His tag)
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- Target See all Activin A Receptor Type IB/ALK-4 (ACVR1B) Proteins
- Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Activin A Receptor Type IB/ALK-4 protein is labelled with Fc Tag,His tag.
- Purpose
- Active Recombinant Human ALK-4/ACVR1B Protein
- Sequence
- MAESAGASSF FPLVVLLLAG SGGSGPRGVQ ALLCACTSCL QANYTCETDG ACMVSIFNLD GMEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYTDY CNRIDLRVPS GHLKEPEHPS MWGPVE
- Specificity
- Met1-Glu126
- Purity
- > 97 % by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- < 0.1 EU/μg of the protein by LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized Human ACVR1B at 0.5 μg/mL (100 μL/well) can bind Human ACVR2B with a linear range of 2.0-286.1 ng/mL.
- Top Product
- Discover our top product ACVR1B Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- Buffer
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store the lyophilized protein at -20°C to -80 °C for long term.|After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
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- Target
- Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))
- Alternative Name
- ALK-4/ACVR1B (ACVR1B Products)
- Synonyms
- ACVR1B Protein, alk4 Protein, skr2 Protein, alk-4 Protein, xalk4 Protein, actrib Protein, acvrlk4 Protein, DKFZp469A1614 Protein, 6820432J04 Protein, ActR-IB Protein, ActRIB Protein, Acvrlk4 Protein, Alk4 Protein, SKR2 Protein, ACTRIB Protein, ACVRLK4 Protein, ALK4 Protein, Skr2 Protein, axis Protein, taram-a Protein, tarama Protein, wu:fb75f01 Protein, activin A receptor type 1B Protein, Activin receptor type-1B Protein, activin A receptor, type IB Protein, activin A receptor, type 1B Protein, activin A receptor type 1Ba Protein, ACVR1B Protein, acvr1b Protein, acv1b Protein, Acvr1b Protein, acvr1ba Protein
- Background
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Description: ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.
Name: ACTRIB, ACVRLK4, ALK4, SKR2,ACVR1B,ACVRLK4,ALK4,SKR2
- Gene ID
- 91
- UniProt
- P36896-1
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