anti-Adenosylhomocysteinase (AHCY) Antibodies

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. Additionally we are shipping AHCY Proteins (91) and AHCY Kits (24) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
AHCY 191 P23526
AHCY 29443 P10760
AHCY 269378 P50247
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Top anti-AHCY Antibodies at antibodies-online.com

Showing 10 out of 124 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-AHCY Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human Liver 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Ahcy Antibody Titration: 1.0 ug/ml Positive Control: Mouse Pancreas 100 μL 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated FACS, IHC (p), WB AHCY Antibody (N-term) (ABIN655151) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB AHCY Antibody (N-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. AHCY Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of AHCY Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated WB 100 μg 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: Hep G2 , 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded H1299 xenograft, using AdoHcyase, antibody at 1:100 dilution. 100 μL 3 to 4 Days
$466.18
Details
Hamster Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details

Top referenced anti-AHCY Antibodies

  1. Human Monoclonal AHCY Primary Antibody for ELISA, WB - ABIN513196 : Fernandez-Sanchez, Gonatopoulos-Pournatzis, Preston, Lawlor, Cowling: S-adenosyl homocysteine hydrolase is required for Myc-induced mRNA cap methylation, protein synthesis, and cell proliferation. in Molecular and cellular biology 2009 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal AHCY Primary Antibody for ELISA, WB - ABIN543540 : Arredondo-Vega, Charlton, Edwards, Hopkinson, Whitehouse: Isozyme and DNA analysis of human S-adenosyl-L-homocysteine hydrolase (AHCY). in Annals of human genetics 1990 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal AHCY Primary Antibody for IHC (fro), ELISA - ABIN543539 : Yideng, Jianzhong, Ying, Juan, Jinge, Shenglan, Xiaoqun, Shuren: Homocysteine-mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs. in DNA and cell biology 2007 (PubMed)
    Show all 3 Pubmed References

  4. Human Monoclonal AHCY Primary Antibody for ELISA, WB - ABIN559816 : Kim, Kang, Lee, Lee, Yu, Kim, Lee: Identification of S100A8 and S100A9 as serological markers for colorectal cancer. in Journal of proteome research 2009 (PubMed)

  5. Human Polyclonal AHCY Primary Antibody for IF (p), IHC (p) - ABIN708611 : Huang, Huan, Liu: A comparative proteomic analysis reveals important proteins for the fertilization and early embryonic development of the oyster Crassostrea gigas. in Proteomics 2016 (PubMed)

  6. Human Polyclonal AHCY Primary Antibody for IHC - ABIN965520 : Yuan, Borchardt: Photoaffinity labeling of human placental S-adenosylhomocysteine hydrolase with [2-3H]8-azido-adenosine. in The Journal of biological chemistry 1995 (PubMed)
    Show all 4 Pubmed References

More Antibodies against AHCY Interaction Partners

Human Adenosylhomocysteinase (AHCY) interaction partners

  1. Data report that SAHH binds to DNMT1 during DNA replication. SAHH enhances DNMT1 activity, and its overexpression led to hypermethylation of the genome, whereas its inhibition resulted in hypomethylation of the genome. Hypermethylation leads to aberrant gene regulation. Results suggest that alteration of SAHH level affects global DNA methylation levels and gene expression.

  2. Results uncover a H19/SAHH circuit involving gene-methylation alterations by carcinogen BaP.

  3. We investigated previously assumed interaction with AHCY-like-1 protein (AHCYL1), a paralog of AHCY. Indeed, significant interaction between both proteins exists. Additionally, silencing AHCYL1 leads to moderate inhibition of nuclear export of endogenous AHCY.

  4. We have validated the vectors and confirmed self-association of AHCY, AHCYL1, and galectin-3. In a high-throughput BiFC screen, we identified new AHCY interaction partners: galectin-3 and PUS7L. We also describe additional steps in protein interaction analysis, applied for AHCY-galectin-3 interaction

  5. In order to enable the development of small molecule AHCY inhibitors as targeted cancer therapeutics we developed an assay based on a RapidFire high-throughput mass spectrometry detection system, which allows the direct measurement of AHCY enzymatic activity.

  6. SAH hydrolase deficiency can remain asymptomatic in childhood, and the disorder can be associated with early onset hepatocellular carcinoma.

  7. H19 knockdown activates SAHH, leading to increased DNMT3B-mediated methylation of an lncRNA-encoding gene Nctc1 within the Igf2-H19-Nctc1 locus.

  8. S-adenosylhomocysteine hydrolase is regulated by lysine acetylation

  9. SAHH can promote apoptosis, inhibit migration and adhesion of ESCC cells suggesting that it may be involved in carcinogenesis of the esophagus.

  10. A fluorescence-based assay for the measurement of S-adenosylhomocysteine hydrolase activity in biological samples.

  11. The simulations of ligand-induced transition revealed that the signal of intrasubunit closure dynamics is transmitted to form intersubunit contacts, which in turn invoke a precise alignment of active site.

  12. Five active site residues (E156, N181, K186, D190, N191) of AdoHcy hydrolase have been individually mutated to alanine and each engineered enzyme characterized with respect to its redox partial reaction and elimination/addition partial reaction.

  13. a discussion of its hydrolytic activity (review)

  14. Maintenance of ionizable active-site residues in catalytically suitable protonation states in closed forms of placental AHCY may be assisted by a water chain, stabilized by Asp182, that can import and export protons from and to the environment.

  15. AdoHcy is involved in adenosine-induced apoptosis by altering gene expression.

  16. R38W and G123R amino-acid exchanges did not bring about major changes to the catalytic rates. However, circular dichroism analysis showed that both polymorphisms effect the thermal stability.

  17. SAHH, which is diffuse in the cytoplasm of nonmotile Dictyostelium amoebae and human neutrophils, concentrates with F-actin in pseudopods at the front of motile, chemotaxing cells

  18. In the case of Hs-SAHH, the slow-binding phase terminates in micromolar affinity, but over a period of hours, the dissociation rate constant decreases until the final equilibrium affinity is in the nanomolar range.

  19. We found clinically relevant levels of Hcy (0-500 microM) induced elevation of SAH, declination of SAM and SAM/SAH ratio and reduced expression of SAHH and MBD2, but increased activity of DNMT3a and DNMT3b affecting DNA methylation

  20. The mechanism of action of copper on this enzyme sugges a regulative role for copper on the intracellular activity.

Mouse (Murine) Adenosylhomocysteinase (AHCY) interaction partners

  1. These results indicate that epigenetically mediated inhibition of Ahcy expression may be a driving force in causing SAH elevation and subsequent downstream disturbances in transsulfuration and transmethylation pathways during the development and progression of nonalcoholic steatohepatitis.

  2. H19 knockdown activates SAHH, leading to increased DNMT3B-mediated methylation of an lncRNA-encoding gene Nctc1 within the Igf2-H19-Nctc1 locus.

  3. Ahcy was identified from coupling of methylation with gene expression data, shed light on the underlying mechanisms of cytosine demethylation under methyl-deficient conditions.

  4. report the crystallization of mouse SAHH in the presence of the reaction product adenosine. The crystals diffracted to at least 1.55 A degrees resolution and are suitable for X-ray structure analysis at high resolution.

  5. report that Myc promotes upregulation of S-adenosyl homocysteine hydrolase.

Zebrafish Adenosylhomocysteinase (AHCY) interaction partners

  1. AHCYL1 has a different function from AHCY and plays an important role in embryogenesis by modulating inositol 1,4,5-trisphosphate receptor function for the intracellular calcium release

  2. Hepatic steatosis and liver degeneration are prominent features of the ducttrip (dtp) mutant phenotype. Positional cloning identified a causative mutation in the gene encoding S-adenosylhomocysteine hydrolase (Ahcy).

AHCY Antigen Profile

Protein Summary

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with AHCY

  • adenosylhomocysteinase (AHCY) antibody
  • adenosylhomocysteinase (ahcy) antibody
  • adenosylhomocysteinase (ahcY) antibody
  • Adenosylhomocysteinase (ahcY) antibody
  • adenosylhomocysteinase (MMAH_RS02605) antibody
  • adenosylhomocysteinase (Srot_2217) antibody
  • adenosylhomocysteinase (Ndas_3755) antibody
  • adenosylhomocysteinase (Deba_0936) antibody
  • adenosylhomocysteinase (Palpr_2392) antibody
  • adenosylhomocysteinase (Calni_0569) antibody
  • adenosylhomocysteinase (LOC100282150) antibody
  • adenosylhomocysteinase (Intca_2510) antibody
  • adenosylhomocysteinase (Marky_0392) antibody
  • adenosylhomocysteinase (Desac_1394) antibody
  • S-adenosylhomocysteine hydrolase (Tc00.1047053511229.50) antibody
  • S-adenosylhomocysteine hydrolase (Tc00.1047053511589.200) antibody
  • S-adenosylhomocysteine hydrolase (Tb11.01.1350) antibody
  • S-adenosylhomocysteine hydrolase (LMJF_36_3910) antibody
  • S-adenosylhomocysteine hydrolase (MCYG_06244) antibody
  • S-adenosylhomocysteine hydrolase (Ahcy) antibody
  • adenosylhomocysteinase (Ahcy) antibody
  • adenosylhomocysteinase S homeolog (ahcy.S) antibody
  • AA987153 antibody
  • adoHcyase antibody
  • ahcy antibody
  • AL024110 antibody
  • cb1079 antibody
  • CuBP antibody
  • D150 antibody
  • hm:zeh1173 antibody
  • hm:zeh1364 antibody
  • PSPTO5068 antibody
  • SAHH antibody
  • wu:fj67b02 antibody

Protein level used designations for AHCY

S-adenosylhomocysteine hydrolase , adenosylhomocysteinase , Adenosylhomocysteinase , adenosylhomocysteinase-like , S-adenosyl-L-homocysteine hydrolase , adoHcyase , S-adenosyl-L-homocysteine hydrolase B , adenosylhomocysteinase B , adoHcyase B , liver copper-binding protein , dtp

GENE ID SPECIES
458190 Pan troglodytes
733486 Xenopus (Silurana) tropicalis
1186753 Pseudomonas syringae pv. tomato str. DC3000
8681312 Methanocella paludicola SANAE
8790426 Azospirillum sp. B510
8994525 Salinibacter ruber M8
9483094 Candidatus Nitrospira defluvii
100440671 Pongo abelii
8982664 Methanohalophilus mahii DSM 5219
9180283 Segniliparus rotundus DSM 44985
9247624 Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111
9493389 Desulfarculus baarsii DSM 2075
10000059 Paludibacter propionicigenes WB4
10008577 Calditerrivibrio nitroreducens DSM 19672
100282150 Zea mays
10085337 Intrasporangium calvum DSM 43043
10433277 Marinithermus hydrothermalis DSM 14884
10436597 Desulfobacca acetoxidans DSM 11109
3539733 Trypanosoma cruzi strain CL Brener
3547847 Trypanosoma cruzi strain CL Brener
3664299 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5655685 Leishmania major strain Friedlin
9227886 Arthroderma otae CBS 113480
100113808 Nasonia vitripennis
191 Homo sapiens
29443 Rattus norvegicus
503682 Xenopus laevis
477198 Canis lupus familiaris
497050 Sus scrofa
508158 Bos taurus
269378 Mus musculus
387530 Danio rerio
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