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The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Additionally we are shipping ACMSD Antibodies (26) and ACMSD Kits (9) and many more products for this protein.
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Acmsd gene expression was found to be under the control of both hepatocyte nuclear factor 4alpha (HNF4alpha) and peroxisome proliferator-activated receptor alpha (PPARalpha).
The minor C allele of the ACMSD SNP rs2121337 was more prevalent in suicide attempters.
The crystal structures of the human enzyme in its native catalytically active state, a substrate analogue-bound form and a selected active site mutant form with one of the putative substrate binding residues altered, are reported.
ACMSD is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism. ACMSD mutation contributes to the development of Familial cortical myoclonic tremor and epilepsy.
Data report a crystal structure of human ACMSD in complex with the glycolytic intermediate 1,3-dihydroxyacetonephosphate (DHAP),suggesting a regulatory link between NAD synthesis and glycolysis.
identification and expression of cDNA
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase\; EC 184.108.40.206) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.
aminocarboxymuconate semialdehyde decarboxylase
, 2-amino-3-carboxylmuconate-6-semialdehyde decarboxylase
, 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
, 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase-like
, picolinate carboxylase