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Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Additionally we are shipping Anaphase Promoting Complex Subunit 15 Proteins (5) and many more products for this protein.
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Human Polyclonal ANAPC15 Primary Antibody for ICC, IF - ABIN4285964
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
cryo-EM structure of an APC (show APC Antibodies)/C-Cdh1 (show CDH1 Antibodies) complex with Apc1 (show SLC25A24 Antibodies)(WD40 (show DCAF12L2 Antibodies)) deleted showed that the mutant APC (show APC Antibodies)/C is locked into an inactive conformation in which the UbcH10 (show UBE2C Antibodies)-binding site of the catalytic module is inaccessible. Additionally, an EM density for Apc15 is not visible
Anaphase promoting complex subunit 15(APC15) mediates the constant turnover of CDC20 (show CDC20 Antibodies) and mitotic checkpoint (show BUB3 Antibodies) protein complexes, allowing the spindle checkpoint assembly to respond to the attachment state of kinetochores.
APC15 is required for anaphase-promoting complex/cyclosome-bound mitotic checkpoint (show BUB3 Antibodies) complex-dependent CDC20 (show CDC20 Antibodies) autoubiquitylation and degradation and for timely anaphase initiation.
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating to the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.
anaphase-promoting complex subunit 15
, protein HSPC020 homolog