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Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. Additionally we are shipping BST1 Antibodies (154) and BST1 Kits (16) and many more products for this protein.
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Human BST1 Protein expressed in - ABIN1685420
Preugschat, Carter, Boros, Porter, Stewart, Shewchuk: A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157. in Archives of biochemistry and biophysics 2015
Results indicate a neuronal role for CD157 in addition to its known functions in the digestive and immune systems. Less abundant expression of CD157 in the adult brain raises questions about the common features associated with the late onset of Parkinson's disease. Because CD157 is expressed abundantly in the embryonic brain, it may be involved in the processes of neuronal development that relate to psychiatric disorders.
These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in Parkinson's disease.
CD157 molecule displays two distinct domains in its extracellular component. The first is implicated in the enzymic activities of the molecule and the second features adhesion/signalling properties [review]
results suggest that the BST-1-catalyzed generation of extracellular cADPR, followed by the concentrative uptake of the cyclic nucleotide by HP, may be physiologically relevant in normal hemopoiesis
TNF (show TNF Proteins) but not RANK-L led to the sustained upregulation of both CD38 and CD157 as demonstrated by real-time PCR and flow cytometry
Two ADPR cyclase family members (CD38 and CD157) are present in renal preglomerular resistance arterioles, and CD38 participation in acute vascular responses to vasoconstrictors is important in renal microcirculation.
SNPs rs28532698 and rs4301112 in CD157 are not significantly associated with childhood autism spectrum disorder or the severity of the disease in a Chinese Han population.
the rs4698412 variant of BST-1 may increase the Parkinson disease susceptibility. [META-ANALYSIS]
A ligand-receptor complex SCRG1 (show SCRG1 Proteins)/BST1 axis facilitate mesenchymal stem cells migration, preserve OCT4 (show POU5F1 Proteins) and CD271 (show NGFR Proteins) expression, self-renewal and osteogenic differentiation.
Studies indicate that vertebrate ADP-ribosyl cyclases (ARCs) Bst1 and CD38 with common gene structure of invertebrate ARC (show NOL3 Proteins), suggesting the origin to the ancestor of bilaterian animals.
Autism and with features of regression-previously acquired speech lost in the second year of life. The younger sister, who also had asthma, inherited a maternal deletion of 4p15.32 that results in a BST1-CD38 fusion transcript.
BST1 rs11724635 polymorphism can interact with well water drinking to increase the risk of Parkinson's disease in a Taiwanese population.
These findings indicate a central role of CD157 in cell-extracellular matrix interactions and make CD157 an attractive therapeutic target in inflammation and cancer.
The results of this study indicated that the SNCA and BST1 SNPs generally increase the risk of developing PD and that SNCA rs11931074 in particular is associated with a higher risk of parkinson disease with family history.
The results of this study showed that no causative mutation in the BST1 gene in patients with Parkinson's disease.
Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population.
ADP-ribosyl cyclase 2
, ADP-ribosyl cyclase CD157
, bone marrow stromal cell antigen 1
, BP-3 alloantigen
, antigen BP3
, bone marrow stromal antigen 1
, cADPr hydrolase 2
, cyclic ADP-ribose hydrolase 2
, leukocyte antigen 65
, NAD(+) nucleosidase