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CTCF is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. Additionally we are shipping CTCF Kits (11) and CTCF Proteins (8) and many more products for this protein.
Showing 10 out of 105 products:
Human Monoclonal CTCF Primary Antibody for ELISA, WB - ABIN969071
Grbesa, Marinkovic, Ivkic, Kruslin, Novak-Kujundzic, Pegan, Bogdanovic, Bedekovic, Gall-Troselj: Loss of imprinting of IGF2 and H19, loss of heterozygosity of IGF2R and CTCF, and Helicobacter pylori infection in laryngeal squamous cell carcinoma. in Journal of molecular medicine (Berlin, Germany) 2008
Show all 3 Pubmed References
Human Monoclonal CTCF Primary Antibody for ELISA, WB - ABIN965942
Majumder, Gomez, Chadwick, Boss: The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions. in The Journal of experimental medicine 2008
Show all 3 Pubmed References
Human Polyclonal CTCF Primary Antibody for ChIPSeq, ChIP - ABIN2668282
Moriguchi, Yu, Takai, Hayashi, Satoh, Suzuki, Ohneda, Yamamoto: The Human GATA1 Gene Retains a 5' Insulator That Maintains Chromosomal Architecture and GATA1 Expression Levels in Splenic Erythroblasts. in Molecular and cellular biology 2015
Human Polyclonal CTCF Primary Antibody for IP - ABIN153008
Lai, Fatemi, Dhasarathy, Malone, Sobol, Geigerman, Jaye, Mav, Shah, Li, Wade: DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. in The Journal of experimental medicine 2010
Human Polyclonal CTCF Primary Antibody for ChIP, ICC - ABIN4300770
Martínez, Cruz, Lu, Plasschaert, Deng, Rivera-Molina, Bartolomei, Lieberman, Tang: CTCF binding to the first intron of the major immediate early (MIE) gene of human cytomegalovirus (HCMV) negatively regulates MIE gene expression and HCMV replication. in Journal of virology 2014
We propose that cohesin and CTCF have distinct functions in the regulation of runx1 (show RUNX1 Antibodies) during zebrafish embryogenesis.
Data conclude that CTCF modulates MRF (show C11orf9 Antibodies) functional interactions in the orchestration of myogenesis.
CCCTC-binding factor CTCF supports the homeostatic maintenance of hematopoietic stem cell (HSCs) pools by sustaining HSC (show FUT1 Antibodies) quiescence in a reactive oxygen species ROS (show ROS1 Antibodies)-dependent manner.
Authors show that mice devoid of an inducible CTCF binding element, located in the alpha constant gene, display a marked isotype-specific increase of GL transcription in developing and resting splenic B cells and altered CSR (show SCARA3 Antibodies) in activated B cells.
The study provides evidence that CTCF regulates chromatin organization during spermiogenesis, contributing to the functional organization of mature sperm.
CTCF Binding Sites in the Herpes Simplex Virus 1 Genome Display Site-Specific CTCF Occupation, Protein Recruitment, and Insulator Function.
Both LDB1 (show LDB1 Antibodies) and CTCF are required for enhancer-Car2 (show CA2 Antibodies) looping, and the domain of LDB1 (show LDB1 Antibodies) contacted by CTCF is necessary to rescue Car2 (show CA2 Antibodies) transcription in LDB1 (show LDB1 Antibodies)-deficient cells.
CTCF physically associates with Wdr5 (show WDR5 Antibodies) and further transcriptionally controls its expression by directly targeting the Wdr5 (show WDR5 Antibodies) gene promoter.
Since CTCF and cohesin are required for loop domain formation, our results suggest that chromatin loops are dynamic and frequently break and reform throughout the cell cycle.
Nearly half of all DNase (show DNASE2 Antibodies) hypersensitivity sites (both constitutive and dynamic) overlap binding events of the bone-essential RUNX2 (show RUNX2 Antibodies) and/or the chromatin-related CTCF transcription factors.
Chromatin immunoprecipitation-DNA sequence analysis was performed in adult cerebellum and Wiz (show ZNF803 Antibodies) peaks were found at promoters and transcription factor CTCF binding sites.
CTCF knockdown attenuates fear-conditioning-induced hippocampal gene expression of key learning genes and loss of long-range interactions at the BDNF (show BDNF Antibodies) and Arc (show NOL3 Antibodies) loci.
Here, we show that PARP1 (show PARP1 Antibodies) and host insulator protein CTCF colocalize at specific sites throughout the EBV genome and provide evidence to suggest that PARP1 (show PARP1 Antibodies) acts to stabilize CTCF binding and maintain the open chromatin landscape at the active Cp promoter during type III latency. Further, PARP1 (show PARP1 Antibodies) activity is important in maintaining latency type-specific viral gene expression.
HOTTIP cooperates with CTCF to coordinate HOXA gene expression.
CD4 (show CD4 Antibodies)(+) T cells showed the greatest increase (threefold) in ORMDL3 (show ORMDL3 Antibodies) expression in individuals carrying the asthma-risk alleles, where ORMDL3 (show ORMDL3 Antibodies) negatively regulated interleukin-2 (show IL2 Antibodies) production. The asthma-risk variants rs4065275 and rs12936231 switched CTCF-binding sites in the 17q21 locus.
Our data reveal that vigilin (show HDLBP Antibodies) is essential for maintenance of imprinting of IGF2 gene via functional interaction between KH1 (show KCNF1 Antibodies)-7 domains of vigilin (show HDLBP Antibodies) and zinc-finger domains of CTCF.
This study confirms that haploinsufficiency of CTCF causes distinct clinical features, and that a microdeletion encompassing CTCF could cause a recognisable CTCF deletion syndrome. Perturbed DNA methylation (show HELLS Antibodies) at CTCF binding sites, not at imprinted loci, may underlie the pathomechanism of the syndrome.
structural studies show that the sequence-specific interactions between zinc fingers and CTCF-binding sites determine the directionality and conservation of CTCF recognition.
CTCF may be a key factor that contributes to gene co-mutations in cancer.
results support a model in which YY1 (show YY1 Antibodies) acts as an architectural protein to connect developmentally regulated looping interactions; the location of YY1 (show YY1 Antibodies)-mediated interactions may be demarcated in development by a preexisting topological framework created by constitutive CTCF-mediated interactions.
The MeCP2, a protein whose mutated forms are involved in Rett syndrome; and CTCF, a constitutive transcriptional insulator.
The results show that cohesin has an essential genome-wide function in mediating long-range chromatin interactions and support the hypothesis that cohesin creates these by loop extrusion, until it is delayed by CTCF in a manner dependent on PDS5 proteins, or until it is released from DNA by WAPL (show WAPAL Antibodies).
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
transcriptional repressor CTCF
, CCCTC-binding factor (zinc finger protein)
, transcriptional repressor CTCF-like
, 11-zinc finger protein
, CTCFL paralog
, 11 zinc finger transcriptional repressor