CD22 Molecule Proteins (CD22)

Mediates B-cell B-cell interactions. Additionally we are shipping CD22 Antibodies (675) and CD22 Kits (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CD22 12483 P35329
CD22 933 P20273
CD22 308501  
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Top CD22 Proteins at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Human Cells Human His tag 100 μg Log in to see 14 to 16 Days
$440.65
Details
CHO Cells Human Un-conjugated Validation with Western Blot 20 μg Log in to see 4 to 8 Days
$319.00
Details
Human Cells Mouse Fc Tag 100 μg Log in to see 14 to 16 Days
$440.65
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$749.00
Details
HEK-293 Cells Human His tag Human Siglec-2 (176-687), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 21 to 31 Days
$319.00
Details
CHO Cells Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$815.00
Details
Baculovirus infected Insect Cells Human hIgG-His-tag 50 μg Log in to see 13 to 16 Days
$1,230.77
Details

CD22 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
, ,
Human , , , , , ,
, , , , , , ,
Rat (Rattus)
,

More Proteins for CD22 Molecule (CD22) Interaction Partners

Mouse (Murine) CD22 Molecule (CD22) interaction partners

  1. We identified CD22 as a marker of dysregulated microglia in Npc1 mutant mice and subsequently demonstrated that elevated cerebrospinal fluid levels of CD22 in NPC1 patients responds to HPbetaCD administration. Collectively, these data provide the first in-depth analysis of microglia function in NPC1 and suggest possible new therapeutic approaches.

  2. CD22 plays a critical role in regulating TI-2 Ab responses through regulating B-1b cell signaling thresholds.

  3. Thus, proximity labeling with tyramide appears to be a useful method to identify cis-ligands and to analyze their interaction with the lectins.

  4. This combined approach suggests that the inhibitory function of CD22 is influenced by its nanoscale organization and is ensured by its fast diffusion enabling a "global BCR surveillance" at the plasma membrane.

  5. results demonstrate that loss of high affinity CD22 ligands on GC B-cells occurs in both mice and humans through alternative mechanisms, unmasking CD22 relative to naive and memory B-cells

  6. A noncatalytic role for CD45 in regulating tonic, but not antigen-mediated, B-cell antigen receptor (BCR) signaling through modulation of the function of the inhibitory coreceptor CD22, was identified.

  7. CD22 is recruited to the immunological synapse by sialic acid ligands on the Ag-bearing cells, producing a tolerogenic signal involving Lyn and the proapoptotic factor BIM that promotes deletion of the B cell and failure of mice to develop Abs to the Ag upon subsequent challenge.

  8. These data assign a key role to CCL22 in Treg recruitment in the protection of NOD mice against type 1 diabetes following the treatment with G-CSF.

  9. Thus, CD22 plays an essential role in controlling West Nile virus infection by governing cell migration and CD8(+) T cell responses.

  10. that neither B cells nor CD22 are critical for the immediate antiinflammatory activity of IVIgs in mouse models of rheumatoid arthritis and ITP.

  11. Increased red cell turnover in a line of CD22-deficient mice is caused by Gpi1c: a model for hereditary haemolytic anaemia.

  12. novel expression pattern and tissue eosinophilia-regulating function for the "B cell-specific" inhibitory molecule CD22 on GI eosinophils.

  13. As a receptor for sIgM, CD22 induces a negative feedback loop for B-cell activation/

  14. The efficacy of a ligand-targeting approach to B cell-specific depletion therapy for cancer may be the ability of CD22 to recycle and accumulate ligand-decorated cargo intracellularly, as an endocytic receptor.

  15. It regulates B lymphocyte signaling. (review)

  16. CD22 and BLyS promote the survival of overlapping B-cell subsets but contribute to their maintenance through independent and complementary signaling pathways

  17. CD22 deficiency results in prolonged contact hypersensitivity (CHS) reactions and suggests an inhibitory role for CD22 expression, especially during the late phase in elicitation of CHS.

  18. Siglec-G and CD22 have partly compensatory functions and together are crucial in maintaining the B cell tolerance.

  19. Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo.

  20. Data show that anti-CD22 autoantibodies were positive in 80% of TSK/+ mice and in 22% of SSc patients.

Human CD22 Molecule (CD22) interaction partners

  1. Conjugates of these multivalent ligands with auristatin and saporin toxins are efficiently internalized via hCD22 resulting in killing of B-cell lymphoma cells

  2. This is the first time a NMR-based binding study of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt's lymphoma Daudi cells has been described.

  3. Here the authors structurally characterize the ectodomain of CD22 and present its crystal structure with the bound therapeutic antibody epratuzumab, which gives insights into the mechanism of inhibition of B-cell activation.

  4. hCD22 transgenic mice develop normal humoral responses in a peanut allergy oral sensitization model. Homing of B cells to Peyer's patches was partially rescued by expression of hCD22 compared with CD22(-/-) B cells, although not to wild-type levels.

  5. Diabody-based (177)Lu-radioimmunoconjugate for CD22-directed radioimmunotherapy reduced disease burden in a non-Hodgkin lymphoma mouse model.

  6. Siglec-1 and Siglec-2 are potential biomarkers in autoimmune disease. (Review)

  7. We aimed to screen exons 9-14 of the CD22 gene, which is a mutational hot spot region in B-precursor acute lymphoblastic leukemia (pre-B ALL) patients. Nine variants, of which two novel, were found. Novel variants were in introns 10 and 13. Gly745Asp (rs10406069) variant was missense and Cys790Arg (rs79438722) variant was silent.

  8. Anti-CD22-magnetic nanoparticles-doxorubicin inhibited the proliferation of Raji cells, significantly increased the uptake of doxorubicin, and induced apoptosis.

  9. results demonstrate that loss of high affinity CD22 ligands on GC B-cells occurs in both mice and humans through alternative mechanisms, unmasking CD22 relative to naive and memory B-cells

  10. MicroRNA-19a and CD22 Comprise a Feedback Loop for B Cell Response in Sepsis.

  11. These results suggest that the in vivo mechanism of non-ligand-blocking epratuzumab may, in part, involve the unmasking of CD22 to facilitate the trans-interaction of B cells with vascular endothelium.

  12. By using integrative genomics and analysing the relationships of COPD phenotypes with SNPs and gene expression in lung tissue, we identified CST3 and CD22 as potential causal genes for airflow obstruction.

  13. study detected the expression of CD22 and CD72 on B cells of myasthenia gravis, compared to multiple sclerosis patient controls and healthy controls y

  14. In the absence of functional CD22, B cells have a "hyperactivated" phenotype, CD22 dysfunction could contribute to the pathogenesis of autoimmune diseases. (Review)

  15. The finding that CD22 is expressed on lung cancer cells is significant in revealing a heretofore unknown mechanism of tumorigenesis and metastasis

  16. Anti-CD22 recombinant immunotoxin moxetumomab pasudotox has activity in relapsed/refractory hairy cell leukemia.

  17. Our study implicates the CD22DeltaE12 genetic defect in the aggressive biology of relapsed or therapy-refractory paediatric B-lineage ALL.

  18. This CD22-targeted polymer carrier may be useful for siRNA delivery to lymphoma cells.

  19. Results obtained through a large cohort of European caucasian patients with systemic sclerosis do not support the contribution of CD19, CD20, CD22, CD24 variants to the genetic susceptibility.

  20. Taken together, these results suggest that negative regulation of TLR signaling of B cells is an intrinsic property of CD22.

CD22 Protein Profile

Protein Summary

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins\; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Gene names and symbols associated with CD22 Molecule Proteins (CD22)

  • CD22 antigen (Cd22)
  • CD22 molecule (CD22)
  • CD22 molecule (Cd22)
  • A530093D23 protein
  • Lyb-8 protein
  • Lyb8 protein
  • siglec-2 protein
  • SIGLEC2 protein

Protein level used designations for CD22 Molecule Proteins (CD22)

B-cell receptor CD22 , B-lymphocyte cell adhesion molecule , BL-CAM , T-cell surface antigen Leu-14 , sialic acid-binding Ig-like lectin 2 , siglec-2 , CD22 antigen , sialic acid binding Ig-like lectin 2 , Sialic acid-binding Ig-like lectin 2

GENE ID SPECIES
12483 Mus musculus
933 Homo sapiens
514582 Bos taurus
101102835 Ovis aries
308501 Rattus norvegicus
450167 Pan troglodytes
100980861 Pan paniscus
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