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CD22 Protein (His tag,Biotin)

CD22 Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE. Active
Catalog No. ABIN7319857
  • Target See all CD22 Proteins
    CD22 (CD22 Molecule (CD22))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 25
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 22
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    Human Cells
    Purification tag / Conjugate
    This CD22 protein is labelled with His tag,Biotin.
    Purpose
    Recombinant Human B-cell Receptor CD22/Siglec-2/CD22 (C-6His) Biotinylated
    Sequence
    Asp20-Arg687
    Characteristics
    Biotinylated Recombinant Human B-cell Receptor CD22 is produced by our Mammalian expression system and the target gene encoding Asp20-Arg687 is expressed with a 6His, Avi tag at the C-terminus.
    Purity
    >95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Biological Activity Comment
    Loaded Biotinylated Human Siglec-2-His-Avi(Cat#CY36) on HIS1K Biosensor, can bind Anti-Human Siglec-2 mAb-Fc(Cat#NC013) with an affinity constant of 0.16 nM as determined in BLI assay.
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    Discover our top product CD22 Protein
  • Comment

    110-130 kDa

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    CD22 (CD22 Molecule (CD22))
    Alternative Name
    CD22 (CD22 Products)
    Synonyms
    A530093D23 Protein, Lyb-8 Protein, Lyb8 Protein, SIGLEC-2 Protein, SIGLEC2 Protein, siglec-2 Protein, CD22 antigen Protein, CD22 molecule Protein, Cd22 Protein, CD22 Protein
    Background

    Background: Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Human Siglec-2, also known as B-cell antigen CD22 or B-lymphocyte cell adhesion molecule (BL-CAM), is a B-cell restricted glycoprotein that is expressed in the cytoplasm of progenitor B and pre-B cells and on the surface of mature B cells. Two distinct human Siglec-2/CD22 cDNAs that arise from differential RNA processing of the same gene have been isolated. Siglec-2/CD22 is an adhesion molecule that preferentially binds alpha 2,6- linked sialic acid on the same (cis) or adjacent (trans) cells. Interaction of CD22 with trans ligands on opposing cells was found to be favored over the binding of ligands in cis.

    Synonym: B-cell receptor CD22, BL-CAM, B-lymphocyte cell adhesion molecule, CD22 antigenMGC130020, CD22 Molecule, CD22, sialic acid binding Ig-like lectin 2, Siglec-2, SIGLEC2FLJ22814, T-cell surface antigen Leu-14

    Molecular Weight
    78 kDa
    UniProt
    P20273
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