CD22 Products
(CD22 Molecule (CD22))
Categories
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins\; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
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Featured CD22 Categories
CD22 Antibodies
High quality antibodies with extensive validation data.
CD22 ELISA Kits
Reliable ELISA kits for a wide range of species.
CD22 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CD22 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
FACS, WB, ELISA, IHC, ICC
Validations
- (2)
- (8)
Cat. No.
ABIN1724888
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
FACS, WB, ELISA, ICC
Validations
- (2)
- (5)
Cat. No.
ABIN1724887
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
FACS, WB, ELISA, IHC, IF, Coat, StM
Validations
- (8)
Cat. No.
ABIN6941120
Quantity
100 μg
Datasheet
Datasheet
Recommended CD22 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965550
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954499
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1889443
Quantity
96 tests
Datasheet
Datasheet
Recommended CD22 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7275595
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275587
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275606
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CD22 products
: "The red blood cell as a novel regulator of human B-cell activation." in: Immunology, Vol. 163, Issue 4, pp. 436-447, (2021) (PubMed).: "Ischemia Reperfusion Injury Triggers CXCL13 Release and B-Cell Recruitment After Allogenic Kidney Transplantation." in: Frontiers in immunology, Vol. 11, pp. 1204, (2020) (PubMed).
: "Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes." in: Frontiers in pharmacology, Vol. 10, pp. 847, (2019) (PubMed).
: "Chimeric antigen receptors that trigger phagocytosis." in: eLife, Vol. 7, (2018) (PubMed).
: "The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression." in: Nature immunology, Vol. 14, Issue 12, pp. 1256-65, (2013) (PubMed).
: "S100+ cells: a new neuro-immune cross-talkers in lymph organs." in: Scientific reports, Vol. 3, pp. 1114, (2013) (PubMed).
: "CD22 antigen is broadly expressed on lung cancer cells and is a target for antibody-based therapy." in: Cancer research, Vol. 72, Issue 21, pp. 5556-65, (2012) (PubMed).
: "CD22 regulates adaptive and innate immune responses of B cells." in: Journal of innate immunity, Vol. 3, Issue 4, pp. 411-9, (2011) (PubMed).
: "TRAIL and DR5 promote thyroid follicular cell apoptosis in iodine excess-induced experimental autoimmune thyroiditis in NOD mice." in: Biological trace element research, Vol. 143, Issue 2, pp. 1064-76, (2011) (PubMed).
: "Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 8, pp. 4143-58, (2010) (PubMed).
Synonyms and alternative names related to CD22
CD22 antigen (Cd22), CD22 molecule (CD22), CD22 molecule (Cd22), A530093D23, Lyb-8, Lyb8, SIGLEC-2, siglec-2, SIGLEC2Protein level used designations for CD22
- B-cell receptor CD22
- B-lymphocyte cell adhesion molecule
- BL-CAM
- T-cell surface antigen Leu-14
- sialic acid-binding Ig-like lectin 2
- siglec-2
- CD22 antigen
- sialic acid binding Ig-like lectin 2
- Sialic acid-binding Ig-like lectin 2
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