CD244 Molecule, Natural Killer Cell Receptor 2B4 Proteins (CD244)

Human CD244 Molecule, Natural Killer Cell Receptor 2B4 (CD244) interaction partners

1. The present study provides further insights into the role of the 2B4-CD48 (show CD48 Proteins) interaction in the fine regulation of CD8 (show CD8A Proteins)(+) T-cell effector function upon antigenic stimulation.

2. Data show that 2B4 not only can bind to CD48 (show CD48 Proteins) in trans but also interacts with CD48 (show CD48 Proteins) in cis (show CISH Proteins) by using the same binding interface. Also, the results demonstrated that constitutive phosphorylation of 2B4 occurs only in the presence of CD48 (show CD48 Proteins), and that cis (show CISH Proteins) binding is sufficient to induce substantial levels of baseline phosphorylation.

3. 2B4 expression is increased on CD4 (show CD4 Proteins)+ T cells in septic patients

4. Self-iNKR(-) NK cells in X-linked lymphoproliferative disease 1 patients are functional even in resting conditions, suggesting a role of the inhibitory 2B4/CD48 (show CD48 Proteins) pathway in the education process during NK-cell maturation.

5. our results provide strong evidence that CD244 co-operates with c-Kit to regulate leukemogenesis through SHP-2 (show PTPN11 Proteins)/p27 (show PAK2 Proteins) signaling.

6. SLAMF4 gene and surface protein expression was down-regulated in CD8 (show CD8A Proteins)+ T cells from SLE patients compared with that in cells obtained from healthy donors. SLAMF4+ effector memory cells produced more granzyme B and perforin (show PRF1 Proteins) than SLAMF4- cells.

7. GSK-3 undergoes inhibitory phosphorylation at regulatory serine residues by the engagement of NKG2D (show KLRK1 Proteins) and 2B4, either individually or in combination.

8. Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8 (show CD8A Proteins)+ T Cell Hyporesponsiveness to Alloantigen

9. CD8 (show CD8A Proteins)(+) T cells require 2B4 for Epstein-Barr virus-specific immune control, because 2B4 blockade after CD8 (show CD8A Proteins)(+) T-cell depletion did not further aggravate symptoms of the infection.

10. CD244 expression/signaling in tuberculosis correlates with high levels of a long noncoding RNA (lncRNA)-BC050410 [named as lncRNA-AS-GSTT1(1 (show GSTT1 Proteins)-72) or lncRNA-CD244] in the CD244(+)CD8 (show CD8A Proteins)(+) T-cell subpopulation.

Mouse (Murine) CD244 Molecule, Natural Killer Cell Receptor 2B4 (CD244) interaction partners

1. 2B4 expression is increased on CD4 (show CD4 Proteins)+ T cells in septic animals

2. 2B4 dampens T-independent B cell responses.

3. DCs from CD244(-/-) mice elicited increased NK cell activation in vitro. These data add CD244 to a growing list of immuno-modulatory receptors found on DCs.

4. Data show that enforced expression of inhibitor of differentiation protein Id3 (show ID3 Proteins) specifically increased the persistence of Cd244 protein 2B4(+) virus-specific CD8 (show CD8A Proteins)(+) T cells.

5. Molecular dynamic simulation explains unbinding and unfolding of CD48 (show CD48 Proteins)-2B4 protein complexes.

6. Signaling via SLAMF4 controls expansion of cytotoxic CD8alphabeta(+) IELs, which regulate the reversible depletion of lamina propria phagocytes and inflammation in the small intestine.

7. CD244 (2B4) has a regulatory effect on mast cells and eosinophils in murine allergic inflammation.

8. NKG2D (show KLRK1 Proteins) ligation relieves 2B4-mediated NK-cell self-tolerance in mice.

9. blockade of CD28 (show CD28 Proteins) signals in the presence of preserved CTLA-4 (show CTLA4 Proteins) signals results in the unique up-regulation of 2B4 on primary CD8 (show CD8A Proteins)(+) effectors, and that this 2B4 expression plays a critical functional role in controlling antigen-specific T8 cell responses

10. In the absence of SAP (show APCS Proteins), signaling through the SLAM (show SLAMF1 Proteins) family members Ly108 (show SLAMF6 Proteins) and 2B4 resulted in increased recruitment of the SHP-1 (show PTPN6 Proteins) phosphatase, associated with altered SHP-1 (show PTPN6 Proteins) localization and decreased activation of Src (show SRC Proteins) kinases at the synapse.