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STS1 encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. Additionally we are shipping Cbl-Interacting Protein Sts-1 Proteins (5) and many more products for this protein.
Showing 10 out of 32 products:
Polyclonal STS1 Primary Antibody for IF, ELISA - ABIN539556
Carpino, Kobayashi, Zang, Takahashi, Jou, Feng, Nakajima, Ihle: Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein. in Molecular and cellular biology 2002
Show all 3 Pubmed References
Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of ZAP70.
The results show that the interaction between STS-1 and ShcA is regulated in response to EGF receptor activation.
The study reveals a role of CBL in restricting myeloid proliferation of human AML1-ETOinduced leukemia, and identifies UBASH3B as a potential target for pharmaceutical intervention.
targeting Aurora B to microtubules by UBASH3B is necessary for the timing and fidelity of chromosome segregation in human cells
These results show that TULA-2 is a target of miR-148a-3p
This recovery involves the phosphorylation of p70 independent of mTOR.
results demonstrate the importance of STS-1 in regulating IFN-alpha-induced autophagy in B cells
UBASH3B is a functional target of anti-invasive microRNA200a that is down-regulated in triple negative breast cancer. Importantly, the oncogenic potential of UBASH3B is dependent on its tyrosine phosphatase activity.
Ablation of TULA-2 resulted in hyperphosphorylation of Syk and its downstream effector phospholipase C-gamma2 as well as enhanced GPVI-mediated platelet functional responses.
Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases
hsp70 inhibits apoptosis upstream and downstream of the mitochondria and is a promising therapeutic target for reversing drug-resistance in chronic myeloid leukemia-blast crisis and acute myeloid leukemia cells.
TULA proteins TULA and TULA-2 regulate activity of the protein tyrosine kinase Syk
Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of Zap70.
Sts-1 and Sts-2 are not required for the immune control of murine herpesvirus 68 in a normal course of gammaherpesvirus infection.
The absence of TULA-2 and also the relative level of TULA-2 expression modulates FcgammaRIIA-mediated platelet reactivity and heparin-induced thrombocytopenia in vivo.
dephosphorylation of Tyr(P)(346) may be considered an important "checkpoint" in the regulation of Syk activation process. Putative biological functions of TULA-2-mediated dephosphorylation of Tyr(P)(346) may include deactivation of receptor-activated Syk or suppression of Syk activation by suboptimal stimulation.
Biochemical analysis identified STS-1 and STS-2 as direct phosphatases of FLT3 and c-KIT.
results demonstrate the importance of STS-1 in regulating IFN-alpha-induced autophagy in B cells.
The lack of TULA-2 facilitates T-cell responses to TCR/CD3 stimulation, thus exacerbating T-cell-dependent inflammation.
TULA-2 negatively regulates osteoclast differentiation and function.
Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation.
Syk is a bona fide TULA-2 substrate in platelets.
Taken together, our data clearly demonstrate the ability of reversine to stimulate adipocyte differentiation, which is independent of the Akt and p70(s6k) signaling pathways.
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.
Cbl-interacting protein Sts-1
, SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate
, T-cell ubiquitin ligand 2
, cbl-interacting protein p70
, nm23-phosphorylated unknown substrate
, suppressor of T-cell receptor signaling 1
, tyrosine-protein phosphatase STS1/TULA2
, ubiquitin-associated and SH3 domain-containing protein B