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CDCA7 was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene.
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Human Polyclonal CDCA7 Primary Antibody for ICC, IF - ABIN4296989
Gill, Gabor, Couzens, Scheid: The MYC-associated protein CDCA7 is phosphorylated by AKT to regulate MYC-dependent apoptosis and transformation. in Molecular and cellular biology 2013
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Transcriptome analysis identified Cdca7 as the top down-regulated gene in Zbtb24 (show ZBTB24 Antibodies) homozygous mutant mESCs, which can be restored by ectopic ZBTB24 (show ZBTB24 Antibodies) expression. Finally, we show that this regulation is conserved between species and that CDCA7 levels are reduced in patients carrying ZBTB24 (show ZBTB24 Antibodies) nonsense mutations
Missense mutations in CDCA7 cause immunodeficiency-centromeric instability-facial anomalies syndrome type 3.
Data indicate that cell division cycle associated 7 protein (show CDCA7L Antibodies) (Cdca7) is strongly up-regulated in the hemogenic population during embryonic stem cell hematopoietic differentiation in a Notch (show NOTCH1 Antibodies)-dependent manner.
The CDCA7 transcription factor regulates cell proliferation.
CDCA7 associates with MYC (show MYC Antibodies) and this association is modulated in a phosphorylation-dependent manner.
JPO1/CDCA7 is a unique transcription regulator whose expression is activated by E2F1 (show E2F1 Antibodies) as well as c-Myc (show MYC Antibodies).
Pax6 (show PAX6 Antibodies) normally represses Cdca7 expression in the lateral cortex and that repression of Cdca7 in cells of this region is required for their production of a normal complement of Tbr2 (show EOMES Antibodies)-expressing intermediate progenitors
This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
cell division cycle associated 7
, cell division cycle associated protein 7
, cell division cycle-associated protein 7
, c-Myc target JPO1