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CBX1 encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family .
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Human Polyclonal CBX1 Primary Antibody for ChIPSeq, IF - ABIN2452034
Kametaka, Takagi, Hayakawa, Haraguchi, Hiraoka, Yoneda: Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins. in Genes to cells : devoted to molecular & cellular mechanisms 2002
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Human Monoclonal CBX1 Primary Antibody for ICC, IF - ABIN2668549
Leshner, Wang, Lewis, Zheng, Chen, Santy, Wang: PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures. in Frontiers in immunology 2012
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Human Polyclonal CBX1 Primary Antibody for IHC (p), IHC - ABIN250825
Sharma, Hwang, Pandita, Gupta, Dhar, Parenteau, Agarwal, Worman, Wellinger, Pandita: Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation. in Molecular and cellular biology 2003
Cow (Bovine) Polyclonal CBX1 Primary Antibody for WB - ABIN2775787
Ayoub, Jeyasekharan, Bernal, Venkitaraman: HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response. in Nature 2008
We demonstrate an unexpected duality in the role of HP1b: it is essential in ESCs (show NR2E3 Antibodies) for maintaining pluripotency, while it is required for proper differentiation in differentiated cells.
The N-terminal portion of LBR (show LBR Antibodies) is probably responsible for the binding to HP1b.
HP1b negatively regulates MMP2 (show MMP2 Antibodies) expression in a transcriptional level and prevents MMP2 (show MMP2 Antibodies) activation through reducing the expression of MT1MMP (show MMP14 Antibodies).
Study concludes that only the 53BP1 (show TP53BP1 Antibodies) status in DNA lesions, induced by UVA or gamma-rays, is affected by A-type lamin (show LMNA Antibodies) deficiency, which was not observed for heterochromatin-related proteins HP1beta and BMI1 (show BMI1 Antibodies).
SUV39h1 (show SUV39H1 Antibodies) associated with HP1 beta in fibrillarin (show FBL Antibodies)-positive nucleolar regions.
demonstrate that a green fluorescent protein-HP1beta fusion protein is highly mobile within both the euchromatin and heterochromatin of ex vivo resting T cells; T cell activation greatly increased this mobility
HP1 (show CBX5 Antibodies) isotypes have specific nonredundant functions; HP1 beta plays an essential role in the shuttling of corepressor transcriptional intermediary factor (TIF)1 (show TRIM24 Antibodies) beta from eu- to heterochromatin during cell differentiation in vivo.
The localization, dynamics, and mobility of HP1beta in the in mouse preimplantation embryos (pro)nucleus were examined.
HP1alpha (show CBX5 Antibodies) and HP1beta proteins on the heterochromatin of transcriptionally active oocytes and their absence in transcriptionally silent oocytes suggest that they are necessary for the repression of RNA synthesis in heterochromatin domains.
HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions
the prolyl residue of the PXXVXL motif appears to play a role distinct from that of Pro in the known HP1beta CSD (show TGFBI Antibodies)-PXVXL complexes.
Data show that heterochromatin protein 1-beta (HP1beta) is a prototypic HP1 (show DEFA1 Antibodies) protein exemplifying most basal chromatin binding and effects.
increased HP1beta expression is associated with the poor prognosis in breast cancer
In this review, we summarize the current knowledge about targeting and functional mechanisms of PRCs, emphasizing the recent breakthroughs related to CBX proteins under a number of physiological and pathological conditions.
Data suggest the reduction of Heterochromatin Protein 1 isoforms HP1beta followed by a decrease in HP1alpha (show CBX5 Antibodies) contributes to the pathogenesis of thyroid carcinomas, and their loss is a potential marker of thyroid malignancy and metastatic potential, respectively.
Phosphorylation at Ser89 and Ser175 results in localized conformational changes in HP1beta that do not compromise the ability of the protein to bind chromatin.
HP1 (show DEFA1 Antibodies) isoforms distinctly augment AR signaling and cell growth in prostate cancer. Therefore, silencing of HP1beta and HP1gamma (show CBX3 Antibodies) may be a promising therapeutic strategy for treatment of prostate cancer.
The structural plasticity of HP1beta supports its ability to bind and connect a wide variety of binding partners in epigenetic processes.
HP1beta which is associated with PCNA (show PCNA Antibodies) in regions of DNA repair, is bound and does not exchange with the mobile pool, suggesting that HP1beta in association with PCNA (show PCNA Antibodies) may be a component of a DNA repair complex.
The HP1beta interactome is enriched with Lys (show LYZ Antibodies) methylated proteins.Role of HP1beta in DNA damage response.
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, chromobox homolog 1
, chromobox protein homolog 1
, heterochromatin protein 1 homolog beta
, heterochromatin protein p25
, modifier 1 protein
, HP1 beta homolog
, chromobox homolog 1 (HP1 beta homolog Drosophila )
, heterochromatin protein 1-beta
, heterochromatin protein p25 beta
, chromobox homolog 1 (HP1 beta homolog)
, chromobox-like protein 1