anti-Chromobox Homolog 1 (CBX1) Antibodies

CBX1 encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . Additionally we are shipping Chromobox Homolog 1 Proteins (8) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CBX1 10951 P83916
CBX1 12412 P83917
CBX1 360609  
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Top anti-Chromobox Homolog 1 Antibodies at

Showing 10 out of 93 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CBX1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  OVCAR-3 cell lysate CBX1 is supported by BioGPS gene expression data to be expressed in OVCAR3 WB Suggested Anti-CBX1 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500 <br /> Positive Control: OVCAR-3 cell lysate <br /> CBX1 is supported by BioGPS gene expression data to be expressed in OVCAR3 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ChIPSeq, IF, WB 50 μg Log in to see 9 to 11 Days
Human Goat Un-conjugated IHC, ELISA, WB ABIN185492 (0.3µg/ml) staining of A431 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN185492 (2.5µg/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 100 μg Log in to see 6 to 7 Days
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: Raji 12% SDS PAGE antibody diluted at 1:1000 IHC-P Image CBX1 / HP1 beta antibody detects CBX1 protein at nucleus on C2C12 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded C2C12 xenograft. CBX1 / HP1 beta antibody , dilution: 1:500. 100 μL Log in to see 3 to 4 Days
Cow Rabbit Un-conjugated WB WB Suggested Anti-CBX1 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:62500  Positive Control:  HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
Human Mouse Un-conjugated ELISA, FACS, ICC, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 2:Western blot analysis using CBX1 mAb against human CBX1 (AA: 1-185) recombinant protein. (Expected MW is 47.3 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of CBX1 Antibody (C-term) (ABIN652861) in MCF-7, A2058, Y79 cell line lysates (35 µg/lane). CBX1 (arrow) was detected using the purified polyclonal antibody. CBX1 Antibody (C-term) (ABIN652861) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
Bat Goat Un-conjugated ELISA, IHC, IHC (p), WB Human Placenta (formalin-fixed, paraffin-embedded) stained with CBX1 antibody ABIN337122 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Anti-CBX1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11 to 14 Days
Bat Rabbit Un-conjugated WB 100 μg Log in to see 11 to 14 Days

Top referenced anti-Chromobox Homolog 1 Antibodies

  1. Human Polyclonal CBX1 Primary Antibody for ChIPSeq, IF - ABIN2452034 : Kametaka, Takagi, Hayakawa, Haraguchi, Hiraoka, Yoneda: Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins. in Genes to cells : devoted to molecular & cellular mechanisms 2002 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal CBX1 Primary Antibody for ICC, IF - ABIN2668549 : Leshner, Wang, Lewis, Zheng, Chen, Santy, Wang: PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures. in Frontiers in immunology 2012 (PubMed)
    Show all 2 Pubmed References

  3. Cow (Bovine) Polyclonal CBX1 Primary Antibody for WB - ABIN2775787 : Ayoub, Jeyasekharan, Bernal, Venkitaraman: HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response. in Nature 2008 (PubMed)

  4. Human Polyclonal CBX1 Primary Antibody for IHC (p), IHC - ABIN250825 : Sharma, Hwang, Pandita, Gupta, Dhar, Parenteau, Agarwal, Worman, Wellinger, Pandita: Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation. in Molecular and cellular biology 2003 (PubMed)

More Antibodies against Chromobox Homolog 1 Interaction Partners

Human Chromobox Homolog 1 (CBX1) interaction partners

  1. the prolyl residue of the PXXVXL motif appears to play a role distinct from that of Pro in the known HP1beta CSD (show TGFBI Antibodies)-PXVXL complexes.

  2. Data show that heterochromatin protein 1-beta (HP1beta) is a prototypic HP1 (show DEFA1 Antibodies) protein exemplifying most basal chromatin binding and effects.

  3. increased HP1beta expression is associated with the poor prognosis in breast cancer

  4. In this review, we summarize the current knowledge about targeting and functional mechanisms of PRCs, emphasizing the recent breakthroughs related to CBX proteins under a number of physiological and pathological conditions.

  5. Data suggest the reduction of Heterochromatin Protein 1 isoforms HP1beta followed by a decrease in HP1alpha (show CBX5 Antibodies) contributes to the pathogenesis of thyroid carcinomas, and their loss is a potential marker of thyroid malignancy and metastatic potential, respectively.

  6. Phosphorylation at Ser89 and Ser175 results in localized conformational changes in HP1beta that do not compromise the ability of the protein to bind chromatin.

  7. HP1 (show DEFA1 Antibodies) isoforms distinctly augment AR signaling and cell growth in prostate cancer. Therefore, silencing of HP1beta and HP1gamma (show CBX3 Antibodies) may be a promising therapeutic strategy for treatment of prostate cancer.

  8. The structural plasticity of HP1beta supports its ability to bind and connect a wide variety of binding partners in epigenetic processes.

  9. HP1beta which is associated with PCNA (show PCNA Antibodies) in regions of DNA repair, is bound and does not exchange with the mobile pool, suggesting that HP1beta in association with PCNA (show PCNA Antibodies) may be a component of a DNA repair complex.

  10. The HP1beta interactome is enriched with Lys (show LYZ Antibodies) methylated proteins.Role of HP1beta in DNA damage response.

Mouse (Murine) Chromobox Homolog 1 (CBX1) interaction partners

  1. We demonstrate an unexpected duality in the role of HP1b: it is essential in ESCs (show NR2E3 Antibodies) for maintaining pluripotency, while it is required for proper differentiation in differentiated cells.

  2. The N-terminal portion of LBR (show LBR Antibodies) is probably responsible for the binding to HP1b.

  3. HP1b negatively regulates MMP2 (show MMP2 Antibodies) expression in a transcriptional level and prevents MMP2 (show MMP2 Antibodies) activation through reducing the expression of MT1MMP (show MMP14 Antibodies).

  4. Study concludes that only the 53BP1 (show TP53BP1 Antibodies) status in DNA lesions, induced by UVA or gamma-rays, is affected by A-type lamin (show LMNA Antibodies) deficiency, which was not observed for heterochromatin-related proteins HP1beta and BMI1 (show BMI1 Antibodies).

  5. SUV39h1 (show SUV39H1 Antibodies) associated with HP1 beta in fibrillarin (show FBL Antibodies)-positive nucleolar regions.

  6. demonstrate that a green fluorescent protein-HP1beta fusion protein is highly mobile within both the euchromatin and heterochromatin of ex vivo resting T cells; T cell activation greatly increased this mobility

  7. HP1 (show CBX5 Antibodies) isotypes have specific nonredundant functions; HP1 beta plays an essential role in the shuttling of corepressor transcriptional intermediary factor (TIF)1 (show TRIM24 Antibodies) beta from eu- to heterochromatin during cell differentiation in vivo.

  8. The localization, dynamics, and mobility of HP1beta in the in mouse preimplantation embryos (pro)nucleus were examined.

  9. HP1alpha (show CBX5 Antibodies) and HP1beta proteins on the heterochromatin of transcriptionally active oocytes and their absence in transcriptionally silent oocytes suggest that they are necessary for the repression of RNA synthesis in heterochromatin domains.

  10. HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions

Chromobox Homolog 1 (CBX1) Antigen Profile

Protein Summary

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with CBX1

  • chromobox 1 (CBX1) antibody
  • chromobox 1 (Cbx1) antibody
  • chromobox homolog 1a (HP1 beta homolog Drosophila) (cbx1a) antibody
  • chromobox 1 S homeolog (cbx1.S) antibody
  • chromobox homolog 1b (HP1 beta homolog Drosophila) (cbx1b) antibody
  • Cbx antibody
  • Cbx-rs2 antibody
  • cbx1 antibody
  • E430007M08Rik antibody
  • HP1-BETA antibody
  • HP1B antibody
  • Hp1beta antibody
  • HP1Hs-beta antibody
  • HP1Hsbeta antibody
  • M31 antibody
  • MOD1 antibody
  • p25beta antibody
  • wu:fe14b09 antibody
  • zgc:55739 antibody
  • zgc:86924 antibody

Protein level used designations for CBX1

HP1 beta homolog , chromobox homolog 1 (HP1 beta homolog Drosophila ) , chromobox protein homolog 1 , heterochromatin protein 1 homolog beta , heterochromatin protein 1-beta , heterochromatin protein p25 beta , modifier 1 protein , HP1 beta , chromobox homolog 1 , heterochromatin protein p25 , chromobox homolog 1 (HP1 beta homolog) , chromobox-like protein 1

10951 Homo sapiens
12412 Mus musculus
360609 Rattus norvegicus
326746 Danio rerio
444708 Xenopus laevis
374237 Gallus gallus
491051 Canis lupus familiaris
616506 Bos taurus
100716439 Cavia porcellus
415180 Danio rerio
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