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May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells.
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Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in Learning Behaviors in Mice
This demonstrates that tauCstF-64 is an important stage-specific regulator of Crem (show CREM Antibodies) mRNA processing that modulates the spatial and temporal expression of downstream stage-specific genes necessary for the proper development of sperm in mice.
The results suggest that tauCstF-64 plays a role in 3' end determination and transcription termination for a large range of germ cell-expressed genes.
tauCstF-64 is required not only for expression of genes involved in morphological differentiation of spermatids but also for genes having products that function during interaction of motile spermatozoa with eggs.
physiologically increased levels of CstF-64 (show CSTF2 Antibodies) observed in LPS (show TLR4 Antibodies)-stimulated RAW macrophages contribute to the changes in expression and alternative polyadenylation of a number of genes
These results suggest the hypothesis that tauCstF-64 mRNA is regulated at the translational or post-translational level.
tauCstF-64 promotes germ-cell-specific patterns of polyadenylation by binding to different downstream sequence elements.
Targeted disruption of Cstf2t in mice causes aberrant spermatogenesis, specifically disrupting meiotic and postmeiotic development, resulting in male infertility resembling oligoasthenoteratozoospermia.
The Cstf2t protein contributes to proteomic diversity by regulating alternative polyadenylation of neural mRNAs.
Studied expression levels of CstF-64 (show CSTF2 Antibodies) in EV71-infected cells; showed reduction of CstF-64 (show CSTF2 Antibodies) during virus infection correlated with production of viral 3C(pro). CstF-64 (show CSTF2 Antibodies) was cleaved in vitro by 3C(pro) not by mutant 3C(pro) variants.
Radiation hybrid mapping places the human tauCstF-64 gene at 10q22-q23, which is the site of a translocation that has been associated with human neurological problems and male infertility.
structure of the RNA-binding domain of CstF-64 (show CSTF2 Antibodies) containing an RNA recognition motif (RRM) augmented by N- and C-terminal helices
upstream element in human papillomavirus type 16 interacted specifically with CstF-64 (show CSTF2 Antibodies), hnRNP C1/C2 (show HNRNPC Antibodies) & polypyrimidine tract binding protein (show PTBP1 Antibodies), suggesting these factors were enhancing or regulating polyadenylation at the HPV-16 early polyadenylation signal
May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs.
CF-1 64 kDa subunit tau
, CF-1 64 kDa subunit, tau
, CSTF 64 kDa subunit tau
, CSTF 64 kDa subunit, tau
, cleavage stimulation factor 64 kDa subunit tau
, cleavage stimulation factor 64 kDa subunit, tau
, cleavage stimulation factor subunit 2 tau
, cleavage stimulation factor subunit 2 tau variant
, cleavage stimulation factor, 3' pre-RNA subunit 2, 64 kDa, tau
, cleavage stimulation factor, 3' pre-RNA subunit 2, tau