CSTF2T antibody (AA 225-275)

Catalog No. ABIN7452301

Product Details anti-CSTF2T Antibody

Target: CSTF2T (Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa, tau Variant (CSTF2T))

Binding Specificity: AA 225-275

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSTF2T antibody is un-conjugated

Application: Immunoprecipitation (IP)

Purpose: Rabbit anti-CSTF2T/TauCSTF64 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 225 and 275

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-CSTF2T/TauCSTF64 antibody A301-487A.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CSTF2T

Target: CSTF2T (Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa, tau Variant (CSTF2T))

Alternative Name: CSTF2T/TauCSTF64 (CSTF2T Products)

Synonyms: 64kDa antibody, C77975 antibody, tCstF-64 antibody, tauCstF-64 antibody, CstF-64T antibody, cleavage stimulation factor, 3' pre-RNA subunit 2, tau antibody, cleavage stimulation factor subunit 2 tau variant antibody, cleavage stimulation factor subunit 2, tau variant antibody, Cstf2t antibody, CSTF2T antibody

Background: Background: CSTF2T, also known as tauCSTF-64, is a paralog of CstF-64, a component of the cleavage stimulation factor (CstF) that processes 3'-end formation and polyadenylation of mRNAs. The human CSTF2T/TauCSTF64 gene is located at 10q22-23, a site associated with neurological problems and male infertility. CSTF2T is expressed in all tissues and throughout meiosis in male germ cells. CstF-64 is also expressed ubiquitously, however because it is located on the X chromosome, its expression is temporarily silenced in germ cells by meiotic sex chromosome inactivation. During this inactivation, it is hypothesized that CSTF2T/TauCSTF64 can compensate for the loss of CstfF-64 expression. Recently, targeted disruption of CSTF2T/TauCSTF64 in mice has been shown to cause aberrant spermatogenesis and infertility providing more evidence for its importance in spermatogenesis.

Gene ID: 23283

NCBI Accession: NP_056050

UniProt: Q9H0L4