Colony Stimulating Factor 3 Receptor (Granulocyte) Proteins (CSF3R)

The protein encoded by CSF3R is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. Additionally we are shipping CSF3R Antibodies (193) and CSF3R Kits (49) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CSF3R 1441 Q99062
CSF3R 12986 P40223
CSF3R 298518  
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Top CSF3R Proteins at antibodies-online.com

Showing 10 out of 26 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Human Cells Human Fc Tag 100 μg Log in to see 14 to 16 Days
$382.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$615.00
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$672.00
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Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$714.00
Details
Escherichia coli (E. coli) Human GST tag Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R) (AA 25-620) protein (GST tag) 50 μg Log in to see 13 to 16 Days
$242.00
Details
HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$275.00
Details
HEK-293 Cells Human Fc Tag 200 μg Log in to see 2 to 3 Days
$319.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$331.20
Details

CSF3R Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced CSF3R Proteins

  1. Human CSF3R Protein expressed in HEK-293 Cells - ABIN2181144 : Ko, Chandra, Ouyang, Kwon, Karande, Han: Nanofluidic device for continuous multiparameter quality assurance of biologics. in Nature nanotechnology 2017 (PubMed)

  2. Human CSF3R Protein expressed in Human Cells - ABIN2002378 : Germeshausen, Ballmaier, Welte: Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: Results of a long-term survey. in Blood 2006 (PubMed)
    Show all 5 Pubmed References

More Proteins for Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R) Interaction Partners

Human Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R) interaction partners

  1. Expression and role of granulocyte macrophage colony-stimulating factor receptor (show CSF2RA Proteins) (GM-CSFR (show CSF2RA Proteins)) and granulocyte colony-stimulating factor receptor (G-CSFR) on Ph-positive acute B lymphoblastic leukemia.

  2. we report here for the first time changes in the allele frequencies of CSF3R-T618I and SETBP1 (show SETBP1 Proteins)-G870S with response to ruxolitnib as well as insights into the clonal evolution of CNL under selective pressure from ruxolitinib.

  3. CSF3R genetic polymorphism occurred more frequently in the individuals with Septic Arthroplasty failure - Periprosthetic Joint Infection.

  4. G-CSF-R is C-mannosylated at W318 and that this C-mannosylation has role(s) for myeloid cell differentiation through regulating downstream signaling.

  5. CSF3R mutations co-occur with CEBPA (show CEBPA Proteins) mutations in pediatric acute myeloid leukemia (show BCL11A Proteins).

  6. we have expanded the region of the CSF3R cytoplasmic domain in which truncation or missense mutations exhibit leukemogenic capacity, which will be useful for evaluating the relevance of CSF3R mutations in patients and helpful in defining targeted therapy strategies.

  7. our data demonstrates that E6AP (show ube3a Proteins) facilitates ubiquitination and subsequent degradation of G-CSFR leading to attenuation of its downstream signaling and inhibition of granulocytic differentiation.

  8. study aimed to identity and characterize novel CSF3R extracellular missense mutations from exome sequencing of leukemia patients; results show the structural and functional importance of conserved extracellular cysteine pairs in CSF3R

  9. a central role of enhanced Mapk (show MAPK1 Proteins) signaling in CSF3R-induced leukemia.

  10. CSF3R T618I mutation is associated with Chronic neutrophilic leukemia.

Mouse (Murine) Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R) interaction partners

  1. Anti-G-CSF receptor rapidly halted the progression of established disease in collagen Ab-induced arthritis in mice. Neutrophil accumulation in joints was inhibited, without rendering animals neutropenic, suggesting an effect of G-CSF receptor blockade on neutrophil homing to inflammatory sites.

  2. this study shows that dorsal root ganglion neurons cultured in G-CSF (show CSF3 Proteins) failed to respond to G-CSF (show CSF3 Proteins) in vitro, and Csf3r gene expression could not be detected in dorsal root ganglion neurons by single-cell RT-PCR

  3. Thr (show TRH Proteins)-615 and Thr (show TRH Proteins)-618 sites of membrane-proximal mutations are part of an O-linked glycosylation cluster. Mutation at these sites prevents O-glycosylation of CSF3R and increases receptor dimerization.

  4. Fbw7 (show FBXW7 Proteins) together with GSK3beta negatively regulates G-CSFR expression and its downstream signaling.

  5. G-CSFR signaling interacts with retinoic acid receptors in the regulation of myeloid differentiation

  6. Expression of truncated G-CSFR significantly shortens the latency of AML (show RUNX1 Proteins) in a G-CSF (show CSF3 Proteins)-dependent fashion and it is associated with a distinct AML (show RUNX1 Proteins) presentation characterized by higher blast counts and more severe myelosuppression.

  7. G-CSFR signals in bone marrow monocytic cells inhibit the production of trophic factors required for osteoblast lineage cell maintenance, ultimately leading to hematopoietic stem and progenitor cell mobilization.

  8. Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF (show CSF3 Proteins)-induced expansion of myeloid progenitor cells.

  9. murine granulocyte colony-stimulating factor receptor binds to a low molecular weight ligand

  10. Mice with truncated G-CSF (show CSF3 Proteins) receptors have neutropenia, susceptibility to infection, and bone marrow maturation arrest similar to severe congenital neutropenic humans, suggesting a role of receptor truncation mutations in SCN (show SRI Proteins) pathology.

Zebrafish Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R) interaction partners

  1. A severe congenital neutropenia CSF3R zebrafish deficient mutant models the human disease.

  2. GCSF (show CSF3 Proteins)/GCSFR is a conserved signaling system for facilitating the production of multiple myeloid cell lineages, as well as for early myeloid cell migration.

CSF3R Protein Profile

Protein Summary

The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia.

Gene names and symbols associated with CSF3R

  • colony stimulating factor 3 receptor (CSF3R)
  • colony stimulating factor 3 receptor (granulocyte) (Csf3r)
  • colony stimulating factor 3 receptor (Csf3r)
  • colony stimulating factor 3 receptor (granulocyte) (csf3r)
  • colony stimulating factor 3 receptor L homeolog (csf3r.L)
  • granulocyte colony-stimulating factor receptor (LOC100433338)
  • cd114 protein
  • CSF3R protein
  • Csfgr protein
  • G-CSF-R protein
  • G-CSFR protein
  • gcsfr protein

Protein level used designations for CSF3R

CD114 antigen , G-CSF receptor , G-CSF-R , granulocyte colony-stimulating factor receptor , colony stimulating factor 3 receptor (granulocyte) , granulocyte stimulating factor receptor , granulocyte colony-stimulating factor receptor-like

GENE ID SPECIES
1441 Homo sapiens
12986 Mus musculus
100069253 Equus caballus
298518 Rattus norvegicus
100134935 Danio rerio
446770 Xenopus laevis
419620 Gallus gallus
607605 Canis lupus familiaris
456756 Pan troglodytes
713485 Macaca mulatta
100433338 Pongo abelii
100464681 Ailuropoda melanoleuca
101118070 Ovis aries
100717194 Cavia porcellus
511511 Bos taurus
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