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DMTF1 encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. Additionally we are shipping Cyclin D Binding Myb-Like Transcription Factor 1 Antibodies (189) and Cyclin D Binding Myb-Like Transcription Factor 1 Proteins (9) and many more products for this protein.
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Cisplatin sensitivity in breast cancer cells is associated with a DMTF1beta splice variant expression.
Study demonstrated that an alternative cyclin D-binding myb-like transcription factor 1 (DMTF1) pre-mRNA splicing isoform, DMTF1 beta, is increasingly expressed in breast cancer and promotes mammary tumorigenesis in a transgenic mouse model. [review].
Low DMTF1 expression is associated with in bladder cancer.
findings imply that DMP1alpha- and beta-ratios are tightly regulated in hematopoietic cells and DMP1beta antagonizes DMP1alpha transcriptional regulation of ARF resulting in the alteration of cellular control with a gain in proliferation
This study reveals a pivotal role of combined Dmp1 loss and cyclin D1 overexpression in breast cancer.
LOH for hDMP1 was associated with luminal A category and longer relapse-free survival
new mechanism of p53 activation mediated by direct physical interaction between Dmp1 and p53.
hDMP1beta antagonizes hDMP1alpha activity and cellular functions of hDMP1 may be regulated by cellular hDMP1 isoform levels
Loss of heterozygosity (LOH) of the hDMP1 gene was detectable in approximately 35% of human lung carcinomas, which was found in mutually exclusive fashion with LOH of INK4a/ARF or that of P53. DMP1 is a pivotal tumor suppressor for human lung cancers.
WT1 downregulation during myeloid differentiation of NB4 and HL60 leukemic cell lines is associated with increased tumor repressor hDMP1 mRNA levels
Dmp1 (Dmp1alpha) physically interacts with p53, stabilizes p53's binding to its target genes, and increases the transcriptional activity of p53.
Results implicate Dmtf1 in the regulation of HSC function through novel cell cycle-regulatory mechanisms.
Data show that Dmp1 directly bound to the genomic loci of Areg, Tsp-1, JunB and Egr1.
a novel Jun-Dmp1 pathway directly links oncogenic Ras-Raf signaling and p19(Arf), independent of the classical cyclin D1/Cdk4-Rb-E2F pathway
The Dmp1-Arf pathway is repressed by p65 in response to genotoxic stress.
Approximately 40% of K-ras(LA) lung tumors from Dmp1(+/+) mice lost one allele of the Dmp1 gene, suggesting the primary involvement of Dmp1 in K-ras-induced tumorigenesis.
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
cyclin D-binding Myb-like protein
, cyclin-D-binding Myb-like transcription factor 1
, cyclin-D-interacting Myb-like protein 1
, D-interacting myb-like protein
, cyclin D binding myb-like transcription factor 1D-interacting myb-like protein
, cyclin D binding myb-like transcription factor 1
, cyclin-D-binding Myb-like transcription factor 1-like