anti-Cyclin-Dependent Kinase 14 (CDK14) Antibodies

Human Cyclin-Dependent Kinase 14 (CDK14) interaction partners

1. CDK14 mediated miR (show MLXIP Antibodies)-1202 to exert its anti-tumor effects.

2. CDK14 expression was closely associated with poor prognosis and overall survival of Osteosarcoma patients. miR (show MLXIP Antibodies)-216a inhibits CDK14 expression by binding to the 3'-untranslated region of CDK14.

3. PFTK1 expression is significantly higher in CRC (show CALR Antibodies) tissues compared with matched adjacent noncancerous colorectal tissues. The associations between PFTK1 expression and clinicopathological characters, and PFTK1 expression and the OS rate following resection suggested that PFTK1 may represent a novel biomarker of poor prognosis in CRC (show CALR Antibodies)

4. Results show that CDK14 and DYRK2 (show DYRK2 Antibodies) expression were inversely correlated in human breast cancer tissues and identified CDK14 as a target of DYRK2 (show DYRK2 Antibodies).

5. miR (show MLXIP Antibodies)-455 inhibits breast cancer cell proliferation through targeting CDK14

6. findings revealed an unrecognized role of Caprin-2 (show CAPRIN2 Antibodies) in facilitating LRP5 (show LRP5 Antibodies)/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14, Cyclin Y (show CCNY Antibodies), and LRP5 (show LRP5 Antibodies)/6.

7. these results suggest that knockdown of PFTK1 inhibited the proliferation and invasion of colon cancer cells as well as the EMT (show ITK Antibodies) progress by suppressing the Sonic hedgehog (show SHH Antibodies) signaling pathway.

8. we report that PFTK1 downregulation might inhibit the proliferation and invasion of NSCLC cells by suppressing the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.

9. The expression level of PFTK1 was correlated with tumor grade, FIGO stage, lymph node metastasis of EOC patients as well as poor prognosis.

10. Knockdown of PFTK1 inhibited the proliferation and invasion of pancreatic cancer cells as well as the EMT (show ITK Antibodies) progress by suppressing the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling pathway.

Mouse (Murine) Cyclin-Dependent Kinase 14 (CDK14) interaction partners

1. Cigarette smoke down regulates CDK14 levels and impairs Wnt (show WNT2 Antibodies) signaling.

2. may be a key regulator for thyrotropin-releasing hormone (TRH (show TRH Antibodies)) action in the cerebellum through the NO-cGMP pathway