anti-Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1) Antibodies

Mouse (Murine) Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1) interaction partners

1. Cdk2ap1 expression is primarily regulated by progesterone and the progesterone receptor in uterus and is mainly localized to proliferating tissues.

2. Results indicate that DOC-1 is a bona fide subunit of the Mi-2/NuRD chromatin remodeling complex.

3. (CDK2-AP1) is a potential gene therapeutic agent for oral/head and neck cancer in conjunction with DNA-damaging agents such as cisplatin.

4. p12CDK2-AP1 forms nuclear homodimers in contact inhibited normal diploid cells and dimerization of p12 is a necessary process for the growth inhibition effect by p12

5. Results suggest that overexpression of CDK2-associating protein 1 (p12CDK2AP1) leads to testicular and ovarian abnormalities, a phenotype closely related to that of cdk2-/- mice.

6. Cdk2ap1, a negative regulator of Cdk2 function and cell cycle, promotes Oct4 promoter methylation during murine embryonic stem cell differentiation to down-regulate Oct4 expression.

7. Cdk2ap1 plays an essential role in the early stage of embryogenesis and has a potential role during craniofacial morphogenesis.

8. CDK2AP1-mediated differentiation of murine embryonic stem cell was elicited through the regulation of pRb.

Human Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1) interaction partners

1. A compelling relationship exists between high CDK2AP1 mRNA expression and lower TNM classification of breast cancer, which is consistent with CDK2AP1 having a tumour-suppressive function.

2. Knockdown of CDK2AP1 in hESCs results in increased p53 and enhances differentiation and favors it over a self-renewal fate.

3. DOC1 re-expression in oral cancer cells causes a reversal of EMT. DOC1 promotes NURD binding to a subset of target loci.

4. The simultaneous overexpression of p12CDK2-AP1 and CD82 significantly suppressed the in vivo tumor growth.

5. knockdown of CDK2AP1 in primary human fibroblasts reduced proliferation and induced premature senescence, with the observed phenotype being p53 dependent

6. In summary, p12CDK2AP1 expression in myxofibrosarcoma cells induces G0/G1 arrest and mitochondria dependent proapoptotic activity and down-regulation of p12CDK2AP1 by shRNAi results in up-regulation of the CDK2 transcript and protein.

7. Study reports that knockdown of CDK2AP1 by RNAi in glioma cells could effectively inhibit cell proliferation by inducing cell cycle arrest and apoptosis

8. CDK2AP1 plays an important role in modulating the growth and tumorigenesis of lung cancer cells.

9. Low CDK2AP1 expression is common and associated with adverse prognosis in nasopharyngeal carcinoma.

10. Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region

11. exerts its effect on stem cell maintenance/differentiation through epigenetic regulation [review]

12. In comparison with the healthy gingiva, the expression of Doc-1 was decreased, whereas the expression of S100A7 was upregulated in all oral lesions.

13. P12(CDK2AP1) is downregulated by miR-21

14. Missing down-regulation of the tumor-suppressor gene DOC-1, might exert protective effects and counteract malignant transformation of benign, proliferating lesions of the oral cavity.

15. Data support the role of cdk2ap1 as a tumor suppressor gene that can regulate squamous cell carcinoma growth in a cell autonomous manner through decreases in invasiveness and a non-cell autonomous manner through decreases in angiogenesis phenotypes.

16. The combination of an increased expression of the antimicrobial peptide DEFA-4, the oncogene S100-A7, epidermal growth factor, and tenascin-c, and a decreased Doc-1 expression in oral leukoplakia might characterize its potency of malignant transformation.

17. Results indicate that DOC-1 is a bona fide subunit of the Mi-2/NuRD chromatin remodeling complex.

18. CDK2AP1 is a novel multiple sclerosis susceptibility loci, and it's risk allele correlates with diminished RNA expression of the cell cycle regulator CDK2AP1

19. Data show low or moderate methylation was found in seven selected genes BAD, BBC3, CAV1, CDK2AP1, NPM1, PRKCDBP and THEM4.

20. DOC1 has a differential expression in microsatellite-unstable human colorectal neoplasms.