DMC1 Dosage Suppressor of Mck1 Homolog, Meiosis-Specific Homologous Recombination (Yeast) (DMC1) ELISA Kits

The protein encoded by DMC1 is essential for meiotic homologous recombination. Additionally we are shipping DMC1 Dosage Suppressor of Mck1 Homolog, Meiosis-Specific Homologous Recombination (Yeast) Antibodies (86) and DMC1 Dosage Suppressor of Mck1 Homolog, Meiosis-Specific Homologous Recombination (Yeast) Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
DMC1 13404 Q61880
DMC1 11144 Q14565
Anti-Rat DMC1 DMC1 362960  
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Top DMC1 Dosage Suppressor of Mck1 Homolog, Meiosis-Specific Homologous Recombination (Yeast) ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Mouse 4.69 pg/mL 18.75-1200 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
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Human
  96 Tests 15 to 18 Days
$875.60
Details

More ELISA Kits for DMC1 Dosage Suppressor of Mck1 Homolog, Meiosis-Specific Homologous Recombination (Yeast) Interaction Partners

Mouse (Murine) DMC1 Dosage Suppressor of Mck1 Homolog, Meiosis-Specific Homologous Recombination (Yeast) (DMC1) interaction partners

  1. In this study, we created a mouse model of a putative infertility allele, DMC1M200V. DMC1 encodes a RecA homolog essential for meiotic recombination and fertility in mice..we found that Dmc1M200V/M200V male and female mice are fully fertile and do not exhibit any gonadal abnormalities

  2. we observed the occurrence of synaptonemal complex bridges between bivalents, most likely representing chromosome translocation events that may involve DMC1, RAD51 or 53BP1.

  3. The DMC1 was highly variable from cell to cell, whereas foci of the crossover marker MLH1 showed little variability.

  4. RAD51AP1 foci colocalize with a subset of DMC1 foci in spermatocytes.

  5. p53 might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells

  6. TBPIP/HOP2 directly binds to DNA and functions as an activator for DMC1 during the homologous pairing step in meiosis

  7. data reveal an interplay among Hop2, Mnd1 and Rad51 and Dmc1 in the formation of the first recombination intermediates during meiosis

  8. Mei1 can be positioned upstream of Dmc1 in the genetic pathway that operates during mammalian meiosis

  9. Dmc1(Mei11) exposes a sex difference in recombination in that a significant portion of female oocytes can compensate for DMC1 deficiency to undergo crossing-over and complete gametogenesis.

Human DMC1 Dosage Suppressor of Mck1 Homolog, Meiosis-Specific Homologous Recombination (Yeast) (DMC1) interaction partners

  1. To the best of our knowledge, this is the first report identifying DMC1 as the causative gene for human non-obstructive azoospermia and premature ovarian insufficiency.

  2. In this study, we created a mouse model of a putative infertility allele, DMC1M200V. DMC1 encodes a RecA homolog essential for meiotic recombination and fertility in mice..we found that Dmc1M200V/M200V male and female mice are fully fertile and do not exhibit any gonadal abnormalities

  3. Data indicate that ahomologous pairing by DMC1 protein or RAD51 recombinase in chromatin containing nucleosome-depleted double-stranded DNA (dsDNA) regions.

  4. BRCA2 protein stimulates DMC1-mediated DNA strand exchange between RPA-ssDNA complexes and duplex DNA, thus identifying BRCA2 as a mediator of DMC1 recombination function.

  5. Dmc1 can reject divergent DNA sequences while bypassing a few mismatches in the DNA sequence.

  6. In contrast to RAD51, stabilization of the presynaptic filament via ATP hydrolysis attenuation is insufficient for enhancement of the DMC1-catalyzed recombination reaction.

  7. truncated DMC1 octamers further stack with alternate polarity into a filament

  8. results suggested mutations in the coding sequence of DMC1 are not associated with premature ovarian failure in Chinese women

  9. conserved lysine in the Walker A motif of hDMC1 is critical for ATP binding.

  10. The results suggested that PSF may function as an activator for the meiosis-specific recombinase DMC1.

  11. RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif.

  12. RAD51AP1 foci colocalize with a subset of DMC1 foci in spermatocytes.

  13. D-loops in a human DMC1-driven reaction are substantially more resistant to dissociation by branch-migration proteins such as RAD54 than those formed by RAD51.

  14. the Dmc1 filament formed on single-stranded DNA has a mass per unit length expected from approximately 6.5 subunits per turn

  15. p53 might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells

  16. The monomeric structure of the Dmc1 protein closely resembled those of the human and archaeal Rad51 proteins. We found another hydrogen bonding interaction at the polymer interface.

  17. hDmc1-mediated DNA recombination initiates through the nucleation of hDmc1 onto ssDNA to form a helical nucleoprotein filament

  18. N-terminal domain of DMC1 is required for the formation of the octamer, which may support the proper DNA binding activity of the DMC1 protein.

  19. activation of hDmc1 is mediated through conformational changes induced by free Ca2+ ion binding to a protein site that is distinct from the Mg2+.ATP-binding center

  20. BRCA2 binds the meiosis-specific recombinase DMC1 and define the primary DMC1 interaction site to a 26 amino-acid region

DMC1 Dosage Suppressor of Mck1 Homolog, Meiosis-Specific Homologous Recombination (Yeast) (DMC1) Antigen Profile

Antigen Summary

The protein encoded by this gene is essential for meiotic homologous recombination. Genetic recombination in meiosis plays an important role in generating diversity of genetic information. The product of this gene is structurally and evolutionary related to the products of the yeast RAD51 and E. coli RecA genes. Alternative splice variants of this gene have been described but their full-length nature has not been determined.

Gene names and symbols associated with DMC1

  • DNA meiotic recombinase 1 (DMC1) antibody
  • DNA meiotic recombinase 1 (dmc1) antibody
  • DNA meiotic recombinase 1 (Dmc1) antibody
  • DCM1 antibody
  • dJ199H16.1 antibody
  • DMC1 antibody
  • DMC1H antibody
  • LIM15 antibody
  • Mei11 antibody
  • sgdp antibody
  • zgc:136628 antibody

Protein level used designations for DMC1

DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) , RecA homolog Dmc1 , disrupted meiotic cDNA 1 , meiotic recombination protein DMC1/LIM15 homolog , meiotic recombination protein DMC1/LIM15 homolog-like , meiotic recombination protein dmc1/lim15-like protein , disrupted meiotic cDNA 1 homolog , DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination , disrupted meiotic cDNA1, yeast, homolog of

GENE ID SPECIES
458831 Pan troglodytes
553953 Danio rerio
608268 Canis lupus familiaris
100055204 Equus caballus
100408835 Callithrix jacchus
100473602 Ailuropoda melanoleuca
100528115 Ictalurus punctatus
100013547 Monodelphis domestica
100579935 Nomascus leucogenys
13404 Mus musculus
427903 Gallus gallus
100522866 Sus scrofa
618398 Bos taurus
11144 Homo sapiens
362960 Rattus norvegicus
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