anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) Antibodies

The protein encoded by DOT1L is a histone methyltransferase that methylates lysine-79 of histone H3. Additionally we are shipping DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Kits (4) and DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DOT1L 84444 Q8TEK3
DOT1L 362831  
DOT1L 208266  
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Top anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Antibodies at antibodies-online.com

Showing 10 out of 87 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB WB Image DOT1L antibody detects DOT1L protein by Western blot analysis. A. H1299 whole cell lysate/extract % SDS-PAGE DOT1L antibody , dilution: 1:1000 100 μL 3 to 4 Days
$466.18
Details
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged DOT1L is approximately 0.03ng/ml as a capture antibody. Immunofluorescence of monoclonal antibody to DOT1L on HeLa cell. [antibody concentration 10 ug/ml] 100 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IHC (p) Formalin-fixed and paraffin embedded human kidney labeled with Anti-DOT1L Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL 3 to 7 Days
$317.90
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of DOT1L expression in HEK293 cells ,The lane on the left is treated with the antigen-specific peptide. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL 11 to 13 Days
$335.04
Details
Human Mouse Un-conjugated IHC, IHC (p), WB   100 μL 11 to 14 Days
$522.50
Details
Human Mouse Un-conjugated WB   100 μL 11 to 14 Days
$522.50
Details
Human Mouse Un-conjugated WB   100 μL 11 to 14 Days
$522.50
Details
Human Mouse Un-conjugated IHC, IHC (p), WB   100 μL 11 to 14 Days
$522.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of HeLa cells, using DOT1L antibody (ABIN5974758) at 1/1000 dilution. 100 μL 11 to 16 Days
$426.40
Details

Top referenced anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Antibodies

  1. Human Polyclonal DOT1L Primary Antibody for ChIP, ICC - ABIN251529 : Steger, Lefterova, Ying, Stonestrom, Schupp, Zhuo, Vakoc, Kim, Chen, Lazar, Blobel, Vakoc: DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. in Molecular and cellular biology 2008 (PubMed)
    Show all 6 Pubmed References

  2. Human Monoclonal DOT1L Primary Antibody for IF, ELISA - ABIN566567 : Phillips, Wildt, Comizzoli: Incidence of methylated histones H3K4 and H3K79 in cat germinal vesicles is regulated by specific nuclear factors at the acquisition of developmental competence during the folliculogenesis. in Journal of assisted reproduction and genetics 2016 (PubMed)

  3. Human Polyclonal DOT1L Primary Antibody for ICC, IF - ABIN251530 : Vernimmen, Lynch, De Gobbi, Garrick, Sharpe, Sloane-Stanley, Smith, Higgs: Polycomb eviction as a new distant enhancer function. in Genes & development 2011 (PubMed)

More Antibodies against DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Interaction Partners

Human DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) interaction partners

  1. We report cryo-EM structures of human Dot1L bound to (1) H2BK120Ub and (2) unmodified nucleosome substrates at 3.5 A and 4.9 A, respectively. Comparison of both structures, complemented with biochemical experiments, provides critical insights into the mechanism of Dot1L stimulation by H2BK120Ub.

  2. results establish the molecular basis of the cross-talk between H2B ubiquitination and H3 Lys79 methylation as well as nucleosome destabilization by DOT1L

  3. DOT1L, LSD1, and HDAC Class I Inhibitors Reduce HOXA9 Expression in MLL-AF9 Rearranged Leukemia Cells, But Dysregulate the Expression of Many Histone-Modifying Enzymes

  4. Study provides evidence that DOT1L plays an important role in an early DNA damage response and repair of DNA double-strand breaks via the homologous recombination pathway.

  5. The present study identifies H3K79me1 and DOT1L upregulation as a novel epigenetic signature of arsenic-exposed humans who have characteristic dermatological lesions.

  6. DOT1L limits Wnt signalling to maintain cartilage homeostasis and protects against osteoarthritis.

  7. DOT1L is essential for activation of NKX2.5 during the cardiac differentiation of human embryonic stem cells.

  8. Each C-Nap1 ring at the proximal end of the two centrioles organizes a rootletin ring and, in addition, multiple rootletin/CEP68 fibers.

  9. Gene and protein expression of DOT1L was increased in synovial tissues of both osteoarthritis and rheumatoid arthritis patients.

  10. human mammary epithelial cells reprogramming is dependent on gene silencing by the DNA methyltransferase DNMT3A and loss of histone transcriptional marks following downregulation of the methyltransferase DOT1L.

  11. this study shows that Dot1l expression predicts adverse postoperative prognosis of patients with clear-cell renal cell carcinoma

  12. facilitates DNA damage repair; plays a protective role in ultraviolet radiation-induced melanomagenesis

  13. DOT1L cooperates with transcription factor ETS-1 to stimulate the expression of VEGFR2, thereby activating ERK1/2 and AKT signaling pathways and promoting angiogenesis.

  14. findings demonstrate that DOT1L over-expression has important clinical significance in ovarian cancer and also clarify that it drives cell cycle progression through transcriptional regulation of CDK6 and CCND3 through H3K79 methylation

  15. MLL-AF4 spreading gene expression is downregulated by inhibitors of the H3K79 methyltransferase DOT1L.

  16. our results identify DOT1L as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma oncogenesis. Furthermore, they characterize DOT1L inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma.

  17. These results reveal a cooperative transcriptional activation mechanism of AEP and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L for more effective treatment of MLL-rearranged leukemia.

  18. this indicates that DOT1L function, like MLL, does not completely rely on its methyltransferase activity. Nevertheless, the small molecule DOT1L inhibition is sufficient to block the proliferation of MLL fusion-induced leukemia cells of murine and human origin

  19. DOT1L may play a critical role in DNMT3A-mutant leukemia.

  20. DOT1L, via dimethylated histone H3 K79, facilitates histone H4 acetylation, which in turn regulates the binding of BRD4 to chromatin in acute lymphoblastic leukemia.

Mouse (Murine) DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) interaction partners

  1. Dysregulated expression of target genes might be implicated in the ataxia phenotype observed in Dot1l-Conditional knockout(Atoh1).

  2. Data from three different mouse models suggest that DOT1L balances transcriptional programs necessary for proper neuronal composition and distribution in the six cortical layers. Furthermore, because loss of DOT1L in the pre-neurogenic phase of development impairs specifically generation of SATB2-expressing upper layer neurons, our data suggest that DOT1L primes upper layer identity in cortical progenitors.

  3. The inhibition of DOT1L or DUSP6 overexpression in T cells attenuates the development of graft-versus-host disease, while retaining potent antitumor activity in xenogeneic and allogeneic adoptive immunotherapy models.

  4. DOT1L limits Wnt signalling to maintain cartilage homeostasis and protects against osteoarthritis.

  5. In the absence of DOT1L, ultraviolet radiation (UVR)-induced DNA damage is inefficiently repaired, so that DOT1L loss promotes melanoma development after exposure to UVR.

  6. We will highlight the structural basis of chromatin targeting of DOT1L through its cofactors and the role of DOT1L in repelling transcription repressive complexes during leukemia development.

  7. These results reveal a cooperative transcriptional activation mechanism of AEP and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L for more effective treatment of MLL-rearranged leukemia.

  8. DOT1L may play a critical role in DNMT3A-mutant leukemia.

  9. DOT1L, via dimethylated histone H3 K79, facilitates histone H4 acetylation, which in turn regulates the binding of BRD4 to chromatin in acute lymphoblastic leukemia.

  10. Dot1l is a new epigenetic regulator of principal cells and intercalated cell differentiation and Atp6v1b1 is a new transcriptional target of Dot1l.

  11. results demonstrate that histone methylation, and in particular DOT1L-mediated H3K79me2 modification, drives cardiomyogenesis through the definition of a specific transcriptional landscape

  12. Interference with DOT1L activity resulted in transcriptional activation of Atf4 and Ddit3 accompanied by decreased levels of H3K79 dimethylation.

  13. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.

  14. DOT1L has a role in inhibiting SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia

  15. Dot1L and H3K79 methylation play important roles in meiosis progression and are supposed to be associated with chromosome deacetylation of mouse oocytes.

  16. Results provide evidence that transformation driven by MLL fusions as well as the recurrent AML-associated NUP98-NSD1 fusion oncogene is critically dependent on the ability of AF10 to stimulate DOT1L activity.

  17. The cytological distribution of the evolutionarily conserved DOT1L methyltransferase and the different H3K79 methylation states resulting from its activity during meiotic prophase I in mouse spermatocytes.

  18. The absence of DOT1L, which is involved in the formation of a specific configuration of heterochromatin at the two-cell stage, is essential for early preimplantation development.

  19. Impaired alphaENaC expression due to failure to inhibit Dot1a-Af9 may play an important role in the early stages of pseudohypoaldosteronism type 1 in MR(-/-) mice.

  20. Our data suggest that DOT1L secures an open chromatin structure in order to reactivate RNA Pol II transcription initiation after a genotoxic attack.

DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) Antigen Profile

Protein Summary

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes.

Gene names and symbols associated with DOT1L

  • histone-lysine N-methyltransferase, H3 lysine-79 specific (LOC100116648) antibody
  • DOT1 like histone lysine methyltransferase (DOT1L) antibody
  • histone methyltransferase (DOT1) antibody
  • DOT1 like histone lysine methyltransferase (Dot1l) antibody
  • DOT1-like, histone H3 methyltransferase (S. cerevisiae) (Dot1l) antibody
  • A630076O07 antibody
  • AW907654 antibody
  • Dot1 antibody
  • DOT1L antibody
  • KMT4 antibody
  • mDot1 antibody
  • NV11307 antibody

Protein level used designations for DOT1L

histone-lysine N-methyltransferase, H3 lysine-79 specific , DOT1-like, histone H3 methyltransferase (S. cerevisiae) , histone-lysine N-methyltransferase, H3 lysine-79 specific-like , possible nucleosomal histone methylase , DOT1-like protein , DOT1-like, histone H3 methyltransferase , H3-K79-HMTase , histone H3-K79 methyltransferase , histone methyltransferase DOT1L , lysine N-methyltransferase 4 , DOT1-like histone H3 methyltransferase , histone H3 methyltransferase DOT1

GENE ID SPECIES
100116648 Nasonia vitripennis
420078 Gallus gallus
100068506 Equus caballus
485073 Canis lupus familiaris
710033 Macaca mulatta
100464435 Ailuropoda melanoleuca
100619840 Monodelphis domestica
3642236 Candida albicans SC5314
84444 Homo sapiens
362831 Rattus norvegicus
208266 Mus musculus
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