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anti-DTL Antibodies

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis.

44 results:

anti-DTL antibody (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (C-Term) Primary Antibody

DTL Reactivity: Human, Mouse FACS, IF, IP, WB Host: Rabbit Polyclonal
Catalog No. ABIN2451940
$500.00
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 9 to 11 Business Days

anti-DTL antibody (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (AA 229-256) Primary Antibody

DTL Reactivity: Human, Mouse EIA, FACS, WB Host: Rabbit Polyclonal
Pubmed 1
Catalog No. ABIN951451
$522.50
Plus shipping costs $45.00
0.4 mL
local_shipping Shipping to: United States
Delivery in 6 to 8 Business Days

anti-DTL antibody (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) Primary Antibody

DTL Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal
Catalog No. ABIN630978
$517.86
Plus shipping costs $45.00
50 μg
local_shipping Shipping to: United States
Delivery in 9 to 11 Business Days

anti-DTL antibody (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (AA 1-730) Primary Antibody

DTL Reactivity: Human IF, WB Host: Rabbit Polyclonal
Catalog No. ABIN949333
$425.71
Plus shipping costs $45.00
100 μg
local_shipping Shipping to: United States
Delivery in 11 to 12 Business Days

anti-DTL antibody (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (AA 229-256) Primary Antibody

DTL Reactivity: Human, Mouse FACS, WB Host: Rabbit Polyclonal
Catalog No. ABIN5538456
$550.00
Plus shipping costs $45.00
400 μL
local_shipping Shipping to: United States
Delivery in 2 to 3 Business Days

anti-DTL antibody (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) Primary Antibody

DTL Reactivity: Human, Mouse FACS, WB Host: Rabbit Polyclonal
Catalog No. ABIN2995947
$590.93
Plus shipping costs $45.00
400 μL (More quantities available)
local_shipping Shipping to: United States
Delivery in 11 to 16 Business Days

anti-DTL antibody (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) Primary Antibody

DTL Reactivity: Human, Mouse ELISA, WB Host: Rabbit Polyclonal
Catalog No. ABIN6390479
$341.69
Plus shipping costs $45.00
100 μL (More quantities available)
local_shipping Shipping to: United States
Delivery in 11 to 13 Business Days

anti-DTL antibody (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) Primary Antibody

DTL Reactivity: Human WB Host: Rabbit Polyclonal
Catalog No. ABIN6139847
$393.25
Plus shipping costs $45.00
100 μL (More quantities available)
local_shipping Shipping to: United States
Delivery in 13 to 14 Business Days

anti-DTL antibody (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (N-Term) Primary Antibody

DTL Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat WB Host: Rabbit Polyclonal
Catalog No. ABIN2782560
$229.00
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 2 to 3 Business Days

anti-DTL antibody (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (AA 182-231) Primary Antibody

DTL Reactivity: Bat, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat WB Host: Rabbit Polyclonal
Catalog No. ABIN6738232
$551.83
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 11 to 14 Business Days

anti-DTL antibody (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (N-Term) Primary Antibody

DTL Reactivity: Human WB Host: Rabbit Polyclonal
Catalog No. ABIN2442043
$318.55
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 2 to 3 Business Days

anti-DTL antibody (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) Primary Antibody

DTL Reactivity: Human, Mouse, Rat IF (p), IHC (p), WB Host: Rabbit Polyclonal
Catalog No. ABIN873173
$327.80
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 4 to 6 Business Days

anti-DTL antibody (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) Primary Antibody

DTL Reactivity: Human, Mouse, Rat ELISA, IP, WB Host: Rabbit Polyclonal
Catalog No. ABIN5705388
$380.00
Plus shipping costs $45.00
100 μg
local_shipping Shipping to: United States
Delivery in 13 to 16 Business Days
Catalog No. ABIN6898039
$416.90
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 6 to 8 Business Days
Catalog No. ABIN6914102
$416.90
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 6 to 8 Business Days
  • Type Primary
    • Primary
  • Target Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
    • Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
    • Histone 3 (H3)
    • Tumor Protein P53 (TP53)
    • Epidermal Growth Factor Receptor (EGFR)
    • Mast/stem Cell Growth Factor Receptor (KIT)
    • Protein tyrosine Phosphatase, Receptor Type, C (PTPRC)
    • tau Protein
    • CD4 Molecule (CD4)
    • Tumor Necrosis Factor alpha (TNF)
    • V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1)
    • Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2)
    • Estrogen Receptor 1 (ESR1)
    • Nuclear Factor-KB P65 (NFkBP65)
    • BCL2-Associated Agonist of Cell Death (BAD)
    • Albumin (ALB)
    • Interferon gamma (IFNG)
    • B-Cell CLL/lymphoma 2 (BCL2)
    • V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1)
    • Heat Shock Protein 70 (HSP70)
    • Amyloid beta (A4) Precursor Protein (APP)
    • CD44
    • Tuberous Sclerosis 2 (TSC2)
    • Myc Proto-Oncogene protein (MYC)
    • Platelet/endothelial Cell Adhesion Molecule (PECAM1)
    • CD19 Molecule (CD19)
    • Histone H4
    • CD8a Molecule (CD8A)
    • Synuclein, alpha (SNCA)
    • Hemagglutinin (HA)
    • Integrin alpha M (ITGAM)
    • CD3e Molecule, epsilon (CD3-TCR Complex) (CD3E)
    • Jun Proto-Oncogene (JUN)
    • CD8
    • Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1)
    • Interleukin 6 (IL6)
    • Vimentin (VIM)
    • Epithelial Cell Adhesion Molecule (EPCAM)
    • Glial Fibrillary Acidic Protein (GFAP)
    • CD5 Molecule (CD5)
    • Interleukin 2 Receptor, alpha (IL2RA)
    • C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)
    • Heat Shock 27kDa Protein 1 (HSPB1)
    • Mucin 1, Cell Surface Associated (MUC1)
    • CD3
    • Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1)
    • PTK2 Protein tyrosine Kinase 2 (PTK2)
    • Interleukin 2 (IL2)
    • Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)
    • CD14
    • CD34
    • alpha-Fetoprotein (AFP)
  • Application
    • Western Blotting (WB)
    • ELISA
    • Flow Cytometry (FACS)
    • Immunohistochemistry (IHC)
    • Immunofluorescence (IF)
    • Immunoprecipitation (IP)
    • Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    • Enzyme Immunoassay (EIA)
    • Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Reactivity
    • Human
    • Mouse
    • Rat
    • Cow
    • Dog
    • Guinea Pig
    • Horse
    • Rabbit
    • Bat
    • Monkey
    • Pig
  • Cited in publications
  • Images available
  • Host
    • Rabbit
    • Chicken
  • Clonality
    • Polyclonal
  • Binding Specificity
    • AA 229-256
    • Center
    • Internal Region
    • AA 393-550
    • AA 1-730
    • C-Term
    • N-Term
    • AA 1-196
    • AA 182-231
    • AA 375-425
    • AA 680-730
    • Middle Region
  • Conjugate
    • Un-conjugated
    • Biotin
    • FITC
    • HRP
    • APC
    • Alkaline Phosphatase (AP)
    • PE
    • Alexa Fluor 488
    • Alexa Fluor 555
    • Alexa Fluor 594
    • Alexa Fluor 647
    • Alexa Fluor 680
    • Alexa Fluor 750
  • Isotype
    • IgG
    • Ig Fraction
  • Format
    • Liquid
    • Lyophilized

DTL Antigen Profile

Protein Summary

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).

Gene names and symbols associated with DTL

  • denticleless E3 ubiquitin protein ligase homolog (DTL) antibody
  • denticleless E3 ubiquitin protein ligase (Dtl) antibody
  • denticleless E3 ubiquitin protein ligase homolog (Dtl) antibody
  • denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S) antibody
  • denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl) antibody
  • 2810047L02Rik antibody
  • 5730564G15Rik antibody
  • cb151 antibody
  • cdt2 antibody
  • cdt2-a antibody
  • chunp6871 antibody
  • dcaf2 antibody
  • l2dtl antibody
  • ramp antibody
  • RGD1310439 antibody
  • wu:fb54b02 antibody

Protein level used designations for DTL

DDB1 and CUL4 associated factor 2 , DDB1- and CUL4-associated factor 2 , RA regulated nuclear matrix associated protein , RA-regulated nuclear matrix-associated protein , denticleless homolog , denticleless protein homolog , lethal(2) denticleless protein homolog , retinoic acid-regulated nuclear matrix-associated protein , Meth A ramp , meth A retinoic acid-regulated nuclear matrix-associated protein , retinoic-acid regulated nuclear matrix-associated protein , denticleless protein homolog A

GENE ID SPECIES
51514 Homo sapiens
76843 Mus musculus
305073 Rattus norvegicus
490279 Canis lupus familiaris
421373 Gallus gallus
735103 Xenopus laevis
539953 Bos taurus
100723475 Cavia porcellus
192314 Danio rerio
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