anti-DTL Antibodies

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis.

Data Quality
  • 1
  • 12
Type
  • 57
    Primary antibodies
Antigen
  • 57
Reactivity
  • 53
  • 28
  • 12
  • 2
  • 2
Application
  • 45
  • 25
  • 19
  • 6
  • 5
Detection Method
  • 3
Host
  • 56
  • 1
Clonality
  • 57
Binding Specificity
  • 18
  • 8
  • 7
  • 4
  • 3
Conjugate
  • 35
  • 4
  • 3
  • 3
  • 2
  • 2
Isotype
  • 36
  • 2
Format
  • 42
  • 3
Suggested next Filters
57 Products
ReactivityHuman, Mouse (Murine)
Application FACS, IF, IP, WB
Order details Cat. No. ABIN2451940
$500.00
100 μL
Plus shipping costs $45.00
Delivery in 9 to 11 Business Days
ReactivityHuman, Mouse (Murine)
Application EIA, FACS, WB
Order details Cat. No. ABIN951451
$522.50
0.4 mL
Plus shipping costs $45.00
Delivery in 6 to 8 Business Days
ReactivityHuman, Mouse (Murine), Rat (Rattus)
Application WB
Order details Cat. No. ABIN630978
$517.86
50 μg
Plus shipping costs $45.00
Delivery in 9 to 11 Business Days
ReactivityHuman
Application IF, WB
Order details Cat. No. ABIN949333
$425.71
100 μg
Plus shipping costs $45.00
Delivery in 11 to 12 Business Days
ReactivityHuman, Mouse (Murine)
Application FACS, WB
Order details Cat. No. ABIN5538456
$550.00
400 μL
Plus shipping costs $45.00
Delivery in 2 to 3 Business Days
ReactivityHuman, Mouse (Murine)
Application FACS, WB
Order details Cat. No. ABIN2995947
$590.93
Plus shipping costs $45.00
Delivery in 11 to 16 Business Days
ReactivityHuman, Mouse (Murine)
Application ELISA, WB
Order details Cat. No. ABIN6390479
$341.69
Plus shipping costs $45.00
Delivery in 11 to 13 Business Days
ReactivityHuman
Application WB
Order details Cat. No. ABIN6139847
$393.25
Plus shipping costs $45.00
Delivery in 13 to 14 Business Days
ReactivityHuman
Application ELISA, WB
Order details Cat. No. ABIN2139447
$510.36
50 μL
Plus shipping costs $45.00
Delivery in 9 to 11 Business Days
ReactivityCow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus)
Application WB
Order details Cat. No. ABIN2782560
$229.00
100 μL
Plus shipping costs $45.00
Delivery in 2 to 3 Business Days
ReactivityMouse (Murine), Rat (Rattus)
Application WB
Order details Cat. No. ABIN6293993
$309.73
50 μL
Plus shipping costs $45.00
Delivery in 11 to 13 Business Days
ReactivityMouse (Murine), Rat (Rattus)
Application WB
Order details Cat. No. ABIN6716311
$390.55
100 μL
Plus shipping costs $45.00
Delivery in 6 to 11 Business Days
ReactivityMouse (Murine), Rat (Rattus)
Application WB
Order details Cat. No. ABIN5997630
$422.09
Plus shipping costs $45.00
Delivery in 11 to 18 Business Days
ReactivityMouse (Murine), Rat (Rattus)
Application WB
Order details Cat. No. ABIN6567351
$438.90
Plus shipping costs $45.00
Delivery in 12 to 14 Business Days
ReactivityBat, Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Monkey, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
Application WB
Order details Cat. No. ABIN6738232
$551.83
100 μL
Plus shipping costs $45.00
Delivery in 11 to 14 Business Days
  • <
  • 1

DTL Antigen Profile

Protein Summary

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).

Gene names and symbols associated with DTL

  • denticleless E3 ubiquitin protein ligase homolog (DTL) antibody
  • denticleless E3 ubiquitin protein ligase (Dtl) antibody
  • denticleless E3 ubiquitin protein ligase homolog (Dtl) antibody
  • denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S) antibody
  • denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl) antibody
  • 2810047L02Rik antibody
  • 5730564G15Rik antibody
  • cb151 antibody
  • cdt2 antibody
  • cdt2-a antibody
  • chunp6871 antibody
  • dcaf2 antibody
  • l2dtl antibody
  • ramp antibody
  • RGD1310439 antibody
  • wu:fb54b02 antibody

Protein level used designations for DTL

DDB1 and CUL4 associated factor 2 , DDB1- and CUL4-associated factor 2 , RA regulated nuclear matrix associated protein , RA-regulated nuclear matrix-associated protein , denticleless homolog , denticleless protein homolog , lethal(2) denticleless protein homolog , retinoic acid-regulated nuclear matrix-associated protein , Meth A ramp , meth A retinoic acid-regulated nuclear matrix-associated protein , retinoic-acid regulated nuclear matrix-associated protein , denticleless protein homolog A

GENE ID SPECIES
51514 Homo sapiens
76843 Mus musculus
305073 Rattus norvegicus
490279 Canis lupus familiaris
421373 Gallus gallus
735103 Xenopus laevis
539953 Bos taurus
100723475 Cavia porcellus
192314 Danio rerio