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The protein encoded by DNM1L is a member of the dynamin superfamily of GTPases. Additionally we are shipping Dynamin 1-Like Proteins (7) and Dynamin 1-Like Kits (6) and many more products for this protein.
Showing 10 out of 125 products:
Fish Polyclonal DNM1L Primary Antibody for ICC, IF - ABIN258397
Manczak, Calkins, Reddy: Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. in Human molecular genetics 2011
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Human Polyclonal DNM1L Primary Antibody for ICC, IF - ABIN258391
Cheng, Guo, Copps, Dong, Kollipara, Rodgers, Depinho, Puigserver, White: Foxo1 integrates insulin signaling with mitochondrial function in the liver. in Nature medicine 2009
Show all 14 Pubmed References
Mouse (Murine) Polyclonal DNM1L Primary Antibody for IHC - ABIN966011
Honda, Hirose: Stage-specific enhanced expression of mitochondrial fusion and fission factors during spermatogenesis in rat testis. in Biochemical and biophysical research communications 2003
Show all 5 Pubmed References
Human Monoclonal DNM1L Primary Antibody for IHC (p), ELISA - ABIN564347
Figueroa-Romero, Iñiguez-Lluhí, Stadler, Chang, Arnoult, Keller, Hong, Blackstone, Feldman: SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
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Human Monoclonal DNM1L Primary Antibody for IHC, ELISA - ABIN1724863
Thomas, Jacobson: Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model. in PLoS ONE 2012
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Human Monoclonal DNM1L Primary Antibody for ICC, FACS - ABIN1724907
Marsboom, Toth, Ryan, Hong, Wu, Fang, Thenappan, Piao, Zhang, Pogoriler, Chen, Morrow, Weir, Rehman, Archer: Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. in Circulation research 2012
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Cow (Bovine) Polyclonal DNM1L Primary Antibody for IHC, WB - ABIN2784887
Su, Chiu, Hung, Hong: Beta-nodavirus B2 protein induces hydrogen peroxide production, leading to Drp1-recruited mitochondrial fragmentation and cell death via mitochondrial targeting. in Apoptosis : an international journal on programmed cell death 2014
Dog (Canine) Monoclonal DNM1L Primary Antibody for IF, WB - ABIN968652
Deyo, Chiao, Tainsky: drp, a novel protein expressed at high cell density but not during growth arrest. in DNA and cell biology 1998
this study shows that Drp1 (show CRMP1 Antibodies) can impact survival of epithelial ovarian cancer patients
The structure and function of DNM1L protein in mitochondrial fission is reviewed.
Results described a recessive disease caused by DNM1L mutations, with a clinical phenotype resembling mitochondrial disorders but without any typical biochemical features. Two novel DNM1L mutations (one frame-shift mutation and one missense mutation) are identified and was found to be associated with impaired mitochondrial and peroxisomal morphology.
Study describes mutations in ZNF143 (show ZNF143 Antibodies) causing a previously undescribed inherited disorder of vitamin B12 (show NDUFB3 Antibodies) (cobalamin) metabolism. These mutations cause an accumulation of transcobalamin-bound cobalamin within the cells, as well as decreased expression of MMACHC (show MMACHC Antibodies), a cobalamin trafficking protein.
The results suggest that endoplasmic reticulum (ER) can function as a platform for Drp1 (show CRMP1 Antibodies) oligomerization, and that ER-associated Drp1 (show CRMP1 Antibodies) contributes to mitochondrial division.
PRKAA (show PRKAA2 Antibodies) deletion promoted mitochondrial fragmentation in vascular endothelial cells by inhibiting the autophagy-dependent degradation of DNM1L.
hepatic stimulator substance could regulate mitochondrial fission and hepatocyte apoptosis during liver ischemia/reperfusion injury by orchestrating the translocation and activation of Drp1 (show CRMP1 Antibodies)
This report describes a patient with a DNM1L mutation and abnormalities in mitochondrial fission and function. The pathogenicity and the dominant nature of the novel p.G362S mutation are demonstrated by overexpression of the mutant gene.
In contrast to the initial report of neonatal lethality resulting from DNM1L mutation and DRP1 (show CRMP1 Antibodies) dysfunction, our results show that milder DRP1 (show CRMP1 Antibodies) impairment is compatible with normal early development and subsequently results in a distinct set of neurological findings. In addition, we identify a common pathogenic mechanism whereby DNM1L mutations impair mitochondrial fission.
These findings provide new insights into MCL-1 (show MCL1 Antibodies) ligands, and the interplay between DRP-1 (show CRMP1 Antibodies) and the anti-apoptotic BCL-2 (show BCL2 Antibodies) family members in the regulation of apoptosis
The Drp1 (show CRMP1 Antibodies) might play a significant role in lamellipodia formation and cell spreading through a different mechanism from that used for regulating mitochondrial dynamics/function.
The structure and function of Dnm1l protein in mitochondrial fission is reviewed.
screening a panel of proteins that regulate mitochondrial morphology in bella GCs (show UGCG Antibodies) revealed de-regulation of phospho-Drp1 (show CRMP1 Antibodies)(Ser616), a key mitochondrial fission regulatory factor. Our data provide new insights into the function of Oxr1 (show OXR1 Antibodies), revealing that specific isoforms of this novel antioxidant protein (show PRDX3 Antibodies) are associated with mitochondria.
Pharmacological inhibition of Drp1 (show CRMP1 Antibodies) prevents mitochondrial fission and reduces myocardial ischemia-reperfusion injury in diabetic mice.
Report a novel non-canonical function of the fission protein, DRP1 (show CRMP1 Antibodies) in maintaining or positively stimulating mitochondrial respiration, bioenergetics and ROS (show ROS1 Antibodies) signalling in adult cardiomyocyte, which is likely independent of morphological changes.
Deletion of Sirt5 (show SIRT5 Antibodies) in starved mouse embryonic fibroblasts increased levels of mitochondrial dynamics leading to mitochondrial accumulation of the pro-fission Drp1 (show CRMP1 Antibodies) and to mitochondrial fragmentation.
Podocyte apoptosis induced by hyperglycemia can be reversed by polydatin through suppressing Drp1 (show CRMP1 Antibodies) expression.
Heat acclimation and heat shock cause changes in mitochondrial morphology of muscle cells by acting on Drp1 (show CRMP1 Antibodies), which results in favoring mitochondrial fusion and fission, respectively.
The authors conclude that clathrin-independent compensatory endocytosis in umbrella cells is integrin regulated and occurs by a RhoA (show RHOA Antibodies)- and dynamin (show DNM1 Antibodies)-dependent pathway.
Data show that short-term induction of Drp1 (show DAPK2 Antibodies), in midlife, is sufficient to improve organismal health and prolong lifespan.
Study showed that exogenous expression of Drp1 (show DAPK2 Antibodies) could promote crawling ability, reduced the level of ATP in Drosophila brain and suppressed neuronal degeneration, suggesting that Drp1 (show DAPK2 Antibodies) is involved in the pathogenesis of Alzheimer disease.
Results show that centronuclear myopathy associated Dyn2 (show DNM2 Antibodies) mutants are gain-of-function mutations, and their primary effect in muscle is T-tubule disorganization, which explains the susceptibility of muscle to Dyn2 (show DNM2 Antibodies) hyperactivity.
Debcl modulates Drp1 (show DAPK2 Antibodies) mitochondrial localization during apoptosis.
Thus, DRP1 (show DAPK2 Antibodies)-dependent mitochondrial fission activity is a novel regulator of the onset of follicle cell differentiation during Drosophila
Alterations in both mitochondrial morphology and ATP production caused by either parkin (show PARK2 Antibodies) or PINK1 (show PINK1 Antibodies) loss of function could be rescued by the mitochondrial fusion proteins Mfn2 (show MFN2 Antibodies) and OPA1 (show OPA1 Antibodies) or by a dominant negative mutant of the fission protein Drp1.
The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.
, dynamin family member proline-rich carboxyl-terminal domain less
, dynamin-1-like protein
, dynamin-like protein 4
, dynamin-like protein IV
, dynamin-related protein 1
, C-terminal region
, N-terminal region
, dynamin-like protein 1
, dynamin 1-like
, Dynamin-1-like protein
, dynamin-1-like protein-like
, dynamin related protein 1
, dynamin-like protein
, CG3210 gene product from transcript CG3210-RB
, dynamin related protein-1
, dynamin-related protein
, dynaminrelated protein 1
, near dpp complementation group 2
, near dpp complementation group 3