Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
The protein encoded by DNM1L is a member of the dynamin superfamily of GTPases. Additionally we are shipping Dynamin 1-Like Kits (8) and Dynamin 1-Like Proteins (7) and many more products for this protein.
Showing 10 out of 133 products:
Fish Polyclonal DNM1L Primary Antibody for ICC, IF - ABIN258397
Manczak, Calkins, Reddy: Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. in Human molecular genetics 2011
Show all 18 Pubmed References
Human Polyclonal DNM1L Primary Antibody for ICC, IF - ABIN258391
Cheng, Guo, Copps, Dong, Kollipara, Rodgers, Depinho, Puigserver, White: Foxo1 integrates insulin signaling with mitochondrial function in the liver. in Nature medicine 2009
Show all 14 Pubmed References
Mouse (Murine) Polyclonal DNM1L Primary Antibody for IHC - ABIN966011
Honda, Hirose: Stage-specific enhanced expression of mitochondrial fusion and fission factors during spermatogenesis in rat testis. in Biochemical and biophysical research communications 2003
Show all 5 Pubmed References
Human Monoclonal DNM1L Primary Antibody for IHC (p), ELISA - ABIN564347
Figueroa-Romero, Iñiguez-Lluhí, Stadler, Chang, Arnoult, Keller, Hong, Blackstone, Feldman: SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
Show all 4 Pubmed References
Human Monoclonal DNM1L Primary Antibody for ICC, FACS - ABIN1724907
Thomas, Jacobson: Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model. in PLoS ONE 2012
Show all 2 Pubmed References
Human Monoclonal DNM1L Primary Antibody for IHC, ELISA - ABIN1724863
Marsboom, Toth, Ryan, Hong, Wu, Fang, Thenappan, Piao, Zhang, Pogoriler, Chen, Morrow, Weir, Rehman, Archer: Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. in Circulation research 2012
Show all 2 Pubmed References
Cow (Bovine) Polyclonal DNM1L Primary Antibody for IHC, WB - ABIN2784887
Su, Chiu, Hung, Hong: Beta-nodavirus B2 protein induces hydrogen peroxide production, leading to Drp1-recruited mitochondrial fragmentation and cell death via mitochondrial targeting. in Apoptosis : an international journal on programmed cell death 2014
Results suggest that the loss of dynamin-related protein 1 (Drp1) expression could contribute to the development of lung and colon cancers.
observations indicate that homozygous p.T115M variant of DNM1L produces a neurological and neurodevelopmental phenotype, consistent with impaired mitochondrial architecture and function, through a diminished ability to oligomerize, which was most prevalent under oxidative stress.
Study results reveal a crucial function for Drp1 (show CRMP1 Antibodies) in regulating tumor growth, mitochondrial morphology, and cell cycle in cutaneous squamous cell carcinoma.
Elimination of Drp1 (show CRMP1 Antibodies) by shRNA or Mdivi-1 (a Drp1 (show CRMP1 Antibodies)-specific inhibitor) suppressed GBP2 (show GBP2 Antibodies)'s regulatory function. Furthermore, GBP2 (show GBP2 Antibodies) blocks Drp1 (show CRMP1 Antibodies) translocation from the cytosol to mitochondria, thereby attenuating Drp1 (show CRMP1 Antibodies)-dependent mitochondrial fission and breast cancer cell invasion.
hyperacetylation of microtubules contributes to the recruitment of total Drp1 (show CRMP1 Antibodies) to mitochondria to enhance fission.
Results uncovered a novel mechanism of Drp1 (show CRMP1 Antibodies)-mediated mitochondrial fragmentation in senecionine-induced liver injury.
miR (show MLXIP Antibodies)-21-5p/203a-3p promote ox-LDL-induced endothelial senescence through down-regulation of Drp1 (show CRMP1 Antibodies) in a direct or indirect way.
this study shows that Drp1 (show CRMP1 Antibodies) can impact survival of epithelial ovarian cancer patients
The structure and function of DNM1L protein in mitochondrial fission is reviewed.
Results described a recessive disease caused by DNM1L mutations, with a clinical phenotype resembling mitochondrial disorders but without any typical biochemical features. Two novel DNM1L mutations (one frame-shift mutation and one missense mutation) are identified and was found to be associated with impaired mitochondrial and peroxisomal morphology.
the transcription of Rho-associated coiled-coil containing protein kinase 1 (ROCK1 (show ROCK1 Antibodies)), which phosphorylates Drp1 (show CRMP1 Antibodies) at Ser616, was shown by luciferase assay to be directly regulated by FOXO1 (show FOXO1 Antibodies). These findings suggested that FOXO1 (show FOXO1 Antibodies) is critical to preserve mitochondrial quantity and function in ECs, and FOXO1 (show FOXO1 Antibodies) may serve as a therapeutic target for microvascular complications of diabetes.
Knockdown of Mtfp1 (show Mtfp1 Antibodies) can minimize doxorubicin cardiotoxicity by inhibiting Dnm1l-mediated mitochondrial fission.
his study demonstrates that inhibition of Drp1 (show CRMP1 Antibodies) hyperactivation by a Drp1 (show CRMP1 Antibodies) peptide inhibitor P110 (show PIK3CA Antibodies) is neuroprotective in a MPTP (show PTPN2 Antibodies) animal model. Our data also suggest that the protective effects of P110 (show PIK3CA Antibodies) treatment might be mediated by inhibiting the p53 (show TP53 Antibodies) mediated apoptotic pathways in neurons through inhibition of Drp1 (show CRMP1 Antibodies)-dependent p53 (show TP53 Antibodies) mitochondrial translocation.
Drp1 (show CRMP1 Antibodies) phosphorylation mediated by c-Abl (show ABL1 Antibodies) is required for oxidative stress-induced (show SQSTM1 Antibodies) cell death in primary cortical neurons.
Our work unraveled a novel function for cofilin1-dependent actin dynamics in mitochondrial fission, and identified cofilin1 as a negative regulator of mitochondrial DRP1 (show CRMP1 Antibodies) activity
Chrysophanol inhibited the LPS (show TLR4 Antibodies)-induced production of proinflammatory mediators and cytokines via suppression of mitogen-activated protein kinase (show MAPK1 Antibodies)/nuclear factor kappa-B activation and reactive oxygen species generation. In addition, chrysophanol downregulated LPS (show TLR4 Antibodies)-induced mitochondrial fission by diminishing dynamin-related protein 1 (Drp1) dephosphorylation.
Mitophagy and mitochondrial spheroid formation are induced by Drp1 (show CRMP1 Antibodies)-deficiency, resulting in fission impairment.
that laforin (show EPM2A Antibodies) and malin (show NHLRC1 Antibodies) are novel regulators of mitochondrial quality control pathway and that the mitochondrial dysfunction resulting from the increased Drp1 (show CRMP1 Antibodies) levels could underlie neuropathology in Lafora disease
In organ cultures of the first molar, tooth germ developed to the early bell stage. The amount of dentin formed under DRP1 (show CRMP1 Antibodies) inhibition was significantly larger than that of the control.
The authors conclude that clathrin-independent compensatory endocytosis in umbrella cells is integrin regulated and occurs by a RhoA (show RHOA Antibodies)- and dynamin (show DNM1 Antibodies)-dependent pathway.
Data show that short-term induction of Drp1 (show DAPK2 Antibodies), in midlife, is sufficient to improve organismal health and prolong lifespan.
Study showed that exogenous expression of Drp1 (show DAPK2 Antibodies) could promote crawling ability, reduced the level of ATP in Drosophila brain and suppressed neuronal degeneration, suggesting that Drp1 (show DAPK2 Antibodies) is involved in the pathogenesis of Alzheimer disease.
Results show that centronuclear myopathy associated Dyn2 (show DNM2 Antibodies) mutants are gain-of-function mutations, and their primary effect in muscle is T-tubule disorganization, which explains the susceptibility of muscle to Dyn2 (show DNM2 Antibodies) hyperactivity.
Debcl modulates Drp1 (show DAPK2 Antibodies) mitochondrial localization during apoptosis.
Thus, DRP1 (show DAPK2 Antibodies)-dependent mitochondrial fission activity is a novel regulator of the onset of follicle cell differentiation during Drosophila
Alterations in both mitochondrial morphology and ATP production caused by either parkin (show PARK2 Antibodies) or PINK1 (show PINK1 Antibodies) loss of function could be rescued by the mitochondrial fusion proteins Mfn2 (show MFN2 Antibodies) and OPA1 (show OPA1 Antibodies) or by a dominant negative mutant of the fission protein Drp1.
The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.
, dynamin family member proline-rich carboxyl-terminal domain less
, dynamin-1-like protein
, dynamin-like protein 4
, dynamin-like protein IV
, dynamin-related protein 1
, C-terminal region
, N-terminal region
, dynamin-like protein 1
, dynamin 1-like
, Dynamin-1-like protein
, dynamin-1-like protein-like
, dynamin related protein 1
, dynamin-like protein
, CG3210 gene product from transcript CG3210-RB
, dynamin related protein-1
, dynamin-related protein
, dynaminrelated protein 1
, near dpp complementation group 2
, near dpp complementation group 3