anti-Dynamin 1-Like (DNM1L) Antibodies

The protein encoded by DNM1L is a member of the dynamin superfamily of GTPases.

list all antibodies Gene Name GeneID UniProt
Anti-Human DNM1L DNM1L 10059 O00429
Anti-Mouse DNM1L DNM1L 74006 Q8K1M6
Anti-Rat DNM1L DNM1L 114114 O35303
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Top anti-Dynamin 1-Like Antibodies at antibodies-online.com

Showing 10 out of 123 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Fish Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, SimWes, WB Staining of renal tubular epithelium and visceral epithelial cells of the glomerulus using ABIN258397 at 2.5ug/ml.  Human kidney cortex, 40X magnification. 0.1 mL Log in to see 7 to 9 Days
$514.63
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, SimWes, WB Staining of renal tubular epithelium and visceral epithelial cells of glomeruli using ABIN258391 at 2.5ug/ml.  Human kidney cortex, 40X magnification. Staining of DRP-1 in mouse embryonic fibroblast post-nuclear extracts using ABIN258391. Image courtesy of D. Chan California Institute of Technology. 0.1 mL Log in to see 7 to 9 Days
$485.88
Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-DNM1L Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>Hela cell lysate <b>Sample Type</b>: 2. mouse brain extracts (80ug)<br> <b>Primary Antibody Dilution:</b> 2ug/ml<br> <b>Secondary Antibody</b>: IRDye 800CW goat anti-rabbit from Li-COR Bioscience<br> <b>Secondary Antibody Dilution:</b> 1: 20,000<br> <b>Image Submitted by</b>: Yuzhi Chen<br> University of Arkansas for Medical Science 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$430.10
Details
Human Mouse Un-conjugated IF, IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using DNM1L antibody. 100 μL Log in to see 16 Days
$334.02
Details
Human Mouse Un-conjugated ICC, FACS, ELISA, WB 100 μL Log in to see 2 to 3 Days
$430.10
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to DNM1L on formalin-fixed paraffin-embedded human leiomyosarcoma tissue. [antibody concentration 1 ug/ml] DNM1L monoclonal antibody (M01), clone 3B5 Western Blot analysis of DNM1L expression in K-562 . 100 μg Log in to see 11 to 12 Days
$440.00
Details

Top referenced anti-Dynamin 1-Like Antibodies

  1. Fish Polyclonal DNM1L Primary Antibody for ICC, IF - ABIN258397 : Manczak, Calkins, Reddy: Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. in Human molecular genetics 2011 (PubMed)
    Show all 18 Pubmed References

  2. Human Polyclonal DNM1L Primary Antibody for ICC, IF - ABIN258391 : Cheng, Guo, Copps, Dong, Kollipara, Rodgers, Depinho, Puigserver, White: Foxo1 integrates insulin signaling with mitochondrial function in the liver. in Nature medicine 2009 (PubMed)
    Show all 14 Pubmed References

  3. Mouse (Murine) Polyclonal DNM1L Primary Antibody for IHC - ABIN966011 : Honda, Hirose: Stage-specific enhanced expression of mitochondrial fusion and fission factors during spermatogenesis in rat testis. in Biochemical and biophysical research communications 2003 (PubMed)
    Show all 5 Pubmed References

  4. Human Monoclonal DNM1L Primary Antibody for IHC (p), ELISA - ABIN564347 : Figueroa-Romero, Iñiguez-Lluhí, Stadler, Chang, Arnoult, Keller, Hong, Blackstone, Feldman: SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 (PubMed)
    Show all 4 Pubmed References

  5. Human Monoclonal DNM1L Primary Antibody for ICC, FACS - ABIN1724907 : Thomas, Jacobson: Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model. in PLoS ONE 2012 (PubMed)
    Show all 2 Pubmed References

  6. Human Monoclonal DNM1L Primary Antibody for IHC, ELISA - ABIN1724863 : Marsboom, Toth, Ryan, Hong, Wu, Fang, Thenappan, Piao, Zhang, Pogoriler, Chen, Morrow, Weir, Rehman, Archer: Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. in Circulation research 2012 (PubMed)
    Show all 2 Pubmed References

  7. Cow (Bovine) Polyclonal DNM1L Primary Antibody for IHC, WB - ABIN2784887 : Su, Chiu, Hung, Hong: Beta-nodavirus B2 protein induces hydrogen peroxide production, leading to Drp1-recruited mitochondrial fragmentation and cell death via mitochondrial targeting. in Apoptosis : an international journal on programmed cell death 2014 (PubMed)

More Antibodies against Dynamin 1-Like Interaction Partners

Human Dynamin 1-Like (DNM1L) interaction partners

  1. Elimination of Drp1 (show CRMP1 Antibodies) by shRNA or Mdivi-1 (a Drp1 (show CRMP1 Antibodies)-specific inhibitor) suppressed GBP2 (show GBP2 Antibodies)'s regulatory function. Furthermore, GBP2 (show GBP2 Antibodies) blocks Drp1 (show CRMP1 Antibodies) translocation from the cytosol to mitochondria, thereby attenuating Drp1 (show CRMP1 Antibodies)-dependent mitochondrial fission and breast cancer cell invasion.

  2. hyperacetylation of microtubules contributes to the recruitment of total Drp1 (show CRMP1 Antibodies) to mitochondria to enhance fission.

  3. Results uncovered a novel mechanism of Drp1 (show CRMP1 Antibodies)-mediated mitochondrial fragmentation in senecionine-induced liver injury.

  4. miR (show MLXIP Antibodies)-21-5p/203a-3p promote ox-LDL-induced endothelial senescence through down-regulation of Drp1 (show CRMP1 Antibodies) in a direct or indirect way.

  5. this study shows that Drp1 (show CRMP1 Antibodies) can impact survival of epithelial ovarian cancer patients

  6. The structure and function of DNM1L protein in mitochondrial fission is reviewed.

  7. Results described a recessive disease caused by DNM1L mutations, with a clinical phenotype resembling mitochondrial disorders but without any typical biochemical features. Two novel DNM1L mutations (one frame-shift mutation and one missense mutation) are identified and was found to be associated with impaired mitochondrial and peroxisomal morphology.

  8. Study describes mutations in ZNF143 (show ZNF143 Antibodies) causing a previously undescribed inherited disorder of vitamin B12 (show NDUFB3 Antibodies) (cobalamin) metabolism. These mutations cause an accumulation of transcobalamin-bound cobalamin within the cells, as well as decreased expression of MMACHC (show MMACHC Antibodies), a cobalamin trafficking protein.

  9. The results suggest that endoplasmic reticulum (ER) can function as a platform for Drp1 (show CRMP1 Antibodies) oligomerization, and that ER-associated Drp1 (show CRMP1 Antibodies) contributes to mitochondrial division.

  10. PRKAA (show PRKAA2 Antibodies) deletion promoted mitochondrial fragmentation in vascular endothelial cells by inhibiting the autophagy-dependent degradation of DNM1L.

Mouse (Murine) Dynamin 1-Like (DNM1L) interaction partners

  1. his study demonstrates that inhibition of Drp1 (show CRMP1 Antibodies) hyperactivation by a Drp1 (show CRMP1 Antibodies) peptide inhibitor P110 (show PIK3CA Antibodies) is neuroprotective in a MPTP (show PTPN2 Antibodies) animal model. Our data also suggest that the protective effects of P110 (show PIK3CA Antibodies) treatment might be mediated by inhibiting the p53 (show TP53 Antibodies) mediated apoptotic pathways in neurons through inhibition of Drp1 (show CRMP1 Antibodies)-dependent p53 (show TP53 Antibodies) mitochondrial translocation.

  2. Drp1 (show CRMP1 Antibodies) phosphorylation mediated by c-Abl (show ABL1 Antibodies) is required for oxidative stress-induced (show SQSTM1 Antibodies) cell death in primary cortical neurons.

  3. Our work unraveled a novel function for cofilin1-dependent actin dynamics in mitochondrial fission, and identified cofilin1 as a negative regulator of mitochondrial DRP1 (show CRMP1 Antibodies) activity

  4. Chrysophanol inhibited the LPS (show TLR4 Antibodies)-induced production of proinflammatory mediators and cytokines via suppression of mitogen-activated protein kinase (show MAPK1 Antibodies)/nuclear factor kappa-B activation and reactive oxygen species generation. In addition, chrysophanol downregulated LPS (show TLR4 Antibodies)-induced mitochondrial fission by diminishing dynamin-related protein 1 (Drp1) dephosphorylation.

  5. Results uncovered a novel mechanism of Drp1 (show CRMP1 Antibodies)-mediated mitochondrial fragmentation in senecionine-induced liver injury.

  6. Mitophagy and mitochondrial spheroid formation are induced by Drp1 (show CRMP1 Antibodies)-deficiency, resulting in fission impairment.

  7. that laforin (show EPM2A Antibodies) and malin (show NHLRC1 Antibodies) are novel regulators of mitochondrial quality control pathway and that the mitochondrial dysfunction resulting from the increased Drp1 (show CRMP1 Antibodies) levels could underlie neuropathology in Lafora disease

  8. In organ cultures of the first molar, tooth germ developed to the early bell stage. The amount of dentin formed under DRP1 (show CRMP1 Antibodies) inhibition was significantly larger than that of the control.

  9. Found that X-irradiation triggered Drp1 (show CRMP1 Antibodies) phosphorylation at serine 616 (S616) but not at serine 637 (S637). Reconstitution analysis revealed that introduction of wild-type (WT) Drp1 (show CRMP1 Antibodies) recovered radiation-induced mitochondrial fission, which was absent in Drp1 (show CRMP1 Antibodies)-deficient cells.

  10. Findings suggest that a partial reduction of Drp1 (show CRMP1 Antibodies) decreases the production of phosphorylated Tau, reduces mitochondrial dysfunction, and maintains mitochondrial dynamics, enhances mitochondrial biogenesis and synaptic activity in Tau mice.

Rabbit Dynamin 1-Like (DNM1L) interaction partners

  1. The authors conclude that clathrin-independent compensatory endocytosis in umbrella cells is integrin regulated and occurs by a RhoA (show RHOA Antibodies)- and dynamin (show DNM1 Antibodies)-dependent pathway.

Fruit Fly (Drosophila melanogaster) Dynamin 1-Like (DNM1L) interaction partners

  1. Data show that short-term induction of Drp1 (show DAPK2 Antibodies), in midlife, is sufficient to improve organismal health and prolong lifespan.

  2. Study showed that exogenous expression of Drp1 (show DAPK2 Antibodies) could promote crawling ability, reduced the level of ATP in Drosophila brain and suppressed neuronal degeneration, suggesting that Drp1 (show DAPK2 Antibodies) is involved in the pathogenesis of Alzheimer disease.

  3. Results show that centronuclear myopathy associated Dyn2 (show DNM2 Antibodies) mutants are gain-of-function mutations, and their primary effect in muscle is T-tubule disorganization, which explains the susceptibility of muscle to Dyn2 (show DNM2 Antibodies) hyperactivity.

  4. Debcl modulates Drp1 (show DAPK2 Antibodies) mitochondrial localization during apoptosis.

  5. Thus, DRP1 (show DAPK2 Antibodies)-dependent mitochondrial fission activity is a novel regulator of the onset of follicle cell differentiation during Drosophila

  6. Alterations in both mitochondrial morphology and ATP production caused by either parkin (show PARK2 Antibodies) or PINK1 (show PINK1 Antibodies) loss of function could be rescued by the mitochondrial fusion proteins Mfn2 (show MFN2 Antibodies) and OPA1 (show OPA1 Antibodies) or by a dominant negative mutant of the fission protein Drp1.

Dynamin 1-Like (DNM1L) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.

Gene names and symbols associated with anti-Dynamin 1-Like (DNM1L) Antibodies

  • dynamin 1 like (DNM1L) antibody
  • dynamin 1-like (Dnm1l) antibody
  • dynamin 1-like L homeolog (dnm1l.L) antibody
  • dynamin 1-like (dnm1l) antibody
  • dynamin-1-like (LOC100369408) antibody
  • dynamin 1 like (dnm1l) antibody
  • dynamin-1-like protein (LOC411472) antibody
  • dynamin-like protein (dyn1) antibody
  • dynamin-like protein (cgd1_580) antibody
  • dynamin-like protein (EHI_052740) antibody
  • dynamin-like protein (PVX_092875) antibody
  • dynamin-like protein (BBOV_II002980) antibody
  • dynamin 1 like (Dnm1l) antibody
  • Dynamin related protein 1 (Drp1) antibody
  • 18.m06247 antibody
  • 6330417M19Rik antibody
  • AI450666 antibody
  • CG3210 antibody
  • Dlp1 antibody
  • Dmel\CG3210 antibody
  • Dnm1/Drp1 antibody
  • DNM1L antibody
  • Dnml1 antibody
  • Dnmlp1 antibody
  • Drp antibody
  • drp-1 antibody
  • drp1 antibody
  • DVLP antibody
  • DYMPLE antibody
  • EMPF antibody
  • frat antibody
  • HDYNIV antibody
  • l(2)22Fc antibody
  • l(2)22Fd antibody
  • l(2)ND2 antibody
  • l(2)ND3 antibody
  • MGC53850 antibody
  • python antibody
  • zgc:66163 antibody

Protein level used designations for anti-Dynamin 1-Like (DNM1L) Antibodies

Dnm1p/Vps1p-like protein , dynamin family member proline-rich carboxyl-terminal domain less , dynamin-1-like protein , dynamin-like protein 4 , dynamin-like protein IV , dynamin-related protein 1 , dymple , C-terminal region , N-terminal region , dynamin-like protein 1 , dynamin 1-like , Dynamin-1-like protein , dynamin-1-like protein-like , dynamin related protein 1 , dynamin-like protein , CG3210 gene product from transcript CG3210-RB , CG3210-PA , CG3210-PB , Drp1-PA , Drp1-PB , dynamin related protein-1 , dynamin-2 , dynamin-related protein , dynaminrelated protein 1 , fratboy , lethal(2)22Fc , lethal(2)22Fd , near dpp complementation group 2 , near dpp complementation group 3 , noodle

GENE ID SPECIES
10059 Homo sapiens
74006 Mus musculus
114114 Rattus norvegicus
379875 Xenopus laevis
393896 Danio rerio
418132 Gallus gallus
465266 Pan troglodytes
477649 Canis lupus familiaris
540892 Bos taurus
695388 Macaca mulatta
100229161 Taeniopygia guttata
100338814 Oryctolagus cuniculus
100369408 Saccoglossus kowalevskii
100380278 Salmo salar
100474116 Ailuropoda melanoleuca
100560647 Anolis carolinensis
411472 Apis mellifera
811008 Plasmodium falciparum 3D7
3371500 Cryptosporidium parvum Iowa II
3405942 Entamoeba histolytica HM-1:IMSS
5474863 Plasmodium vivax Sal-1
5478050 Babesia bovis T2Bo
100728964 Cavia porcellus
33445 Drosophila melanogaster
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