anti-E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) Antibodies

SIAH1 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. Additionally we are shipping SIAH1 Proteins (9) and SIAH1 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIAH1 140941 Q920M9
SIAH1 6477 Q8IUQ4
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Top anti-SIAH1 Antibodies at

Showing 10 out of 125 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated ELISA, WB ABIN184675 staining (0.1µg/ml) of Human Liver lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg 6 to 7 Days
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-SIAH1 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:312500  Positive Control:  Jurkat cell lysate Researcher: Peter Brand & Dr. Oliver Kramer, Institute for Biochemistry and Biophysics, Center for Molecular Biomedicine, Friedrich-Schiller University JenaApplication: Western blottingSpecies+tissue/cell type: Human embryonic kidney 293T How many ug’s of tissue/cell lysate run on the gel: 1:50 µg human HEK-293T cell lysate Primary Antibody dilution: 1:0000Secondary Antibody: Anti-rabbit-IgG Secondary Antibody Dilution: 1:0000 100 μL 2 to 3 Days
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-SIAH1 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:312500  Positive Control:  Human Placenta 100 μL 2 to 3 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from A549/HeLa cells, using SIAH1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
Human Rabbit Un-conjugated EIA, WB Western blot analysis of SIAH1 Antibody (Center) in human placenta tissue lysates (35ug/lane).This demonstrates the SIAH1 antibody detected the SIAH1 protein (arrow). 0.4 mL 6 to 8 Days
Bat Rabbit Un-conjugated IHC, IHC (p), WB Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-SIAH1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other form ... 100 μL 11 to 14 Days
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Bat Goat Un-conjugated ELISA, WB 100 μg 11 to 14 Days
Cow Goat Un-conjugated EIA, IP, WB   0.1 mg 4 to 8 Days
Human Rabbit Un-conjugated IF/ICC, IHC, WB Western blot analysis of extracts of mouse kidney, using SIAH1 antibody (ABIN5971329) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded rat brain using SIAH1 antibody (ABIN5971329) at dilution of 1/100 (40x lens). 100 μL 11 to 16 Days

Top referenced anti-SIAH1 Antibodies

  1. Human Polyclonal SIAH1 Primary Antibody for IP, ELISA - ABIN268796 : Guigon, Zhao, Lu, Willingham, Cheng: Regulation of beta-catenin by a novel nongenomic action of thyroid hormone beta receptor. in Molecular and cellular biology 2008 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal SIAH1 Primary Antibody for ELISA, WB - ABIN184675 : Susini, Passer, Amzallag-Elbaz, Juven-Gershon, Prieur, Privat, Tuynder, Gendron, Israël, Amson, Oren, Telerman: Siah-1 binds and regulates the function of Numb. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 2 Pubmed References

  3. Dog (Canine) Polyclonal SIAH1 Primary Antibody for ELISA, WB - ABIN546788 : Iwai, Marusawa, Matsuzawa, Fukushima, Hijikata, Reed, Shimotohno, Chiba: Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates beta-catenin activity in a p53-dependent manner. in Oncogene 2004 (PubMed)

  4. Monoclonal SIAH1 Primary Antibody for IP, WB - ABIN534024 : Schmidt, Park, Ahmed, Gundelach, Reed, Cheng, Knudsen, Tang: Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue. in Cancer research 2007 (PubMed)

  5. Human Polyclonal SIAH1 Primary Antibody for IHC, IHC (p) - ABIN4353439 : Xiang, Gilkes, Hu, Takano, Luo, Lu, Bullen, Samanta, Liang, Semenza: Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. in Oncotarget 2015 (PubMed)

  6. Cow (Bovine) Polyclonal SIAH1 Primary Antibody for EIA, IP - ABIN5552705 : Donati, Marseglia, Magi, Serratì, Cencetti, Bernacchioni, Nannetti, Benelli, Brunelli, Torricelli, Cossu, Bruni: Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6. in PLoS ONE 2011 (PubMed)

More Antibodies against SIAH1 Interaction Partners

Human E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) interaction partners

  1. Data suggest that lncRNA small nucleolar RNA host gene 1, as a pathogenic factor, promotes alpha-synuclein aggregation and toxicity by targeting the miR-15b-5p/seven in absentia homolog 1 axis.

  2. Results show that abolishing ICP0:SIAH-1 interaction affects the HSV-2 phenotype during infection. In vitro, the SIAH-binding deficient mutant synthesized significantly less DNA and protein, and virus growth was clearly attenuated compared to wild-type virus. In model mice, HSV-2 carrying the SIAH-binding deficient mutation caused an acute infection in the murine eye and was able to spread to the innervating neurons.

  3. Using the novel PUM1 and PUM2 mRNA target SIAH1 as a model, this study shows mechanistic differences between PUM1 and PUM2 and between NANOS1, 2, and 3 paralogues in the regulation of SIAH1.

  4. Depletion of KDM3A coincided with the loss of SIAH1 induction and the accumulation of dimethylated H3K9 surrounding the SIAH1 promoter. Interestingly, KDM3A expression was also up-regulated by nutritional stress in a HIF-1alpha dependent manner.

  5. The crystallographic models provide structural insights into the substrate binding of the SIAH family E3 ubiquitin ligases that are critically involved in regulating cancer-related pathways.

  6. Results showed that SIAH1 and PTP4A1 expression was regulated by mir-944 in breast cancer cells. miR-944 binds directly the 3 UTR of their promotor region.

  7. Study identified SIAH1/2 (SIAH) as the E3 ligase mediating Wnt-induced Axin degradation. SIAH proteins promote the ubiquitination and proteasomal degradation of Axin through interacting with a VxP motif in the GSK3-binding domain of Axin, and this function of SIAH is counteracted by GSK3 binding to Axin.

  8. results suggest that CacyBP/SIP is involved in regulation of the Hsp90 chaperone machinery

  9. PINK1 disease mutants failed to recruit synphilin-1 and did not activate mitophagy, indicating that PINK1-synphilin-1-SIAH-1 represents a new parkin-independent mitophagy pathway. Drugs that activate this pathway will provide a novel strategy to promote the clearance of damaged mitochondria in Parkinson's disease.

  10. Results suggest that activated STAT3 regulates active beta-catenin protein levels via stabilization of SIAH-1 and the subsequent ubiquitin-dependent proteasomal degradation of beta-catenin in HEK293T cells.

  11. Siah-1 expression was observed in 41.4% of oral squamous cell carcinoma. Siah-1 was expressed in the cytoplasm and cell membranes, and partially in the nucleus .

  12. SIAH1 is associated with a tumor promoting role in breast cancer.

  13. In neuroblastoma cells, siRNA silencing of SIAH1 promoted cellular proliferation and suppressed apoptosis. Protein and mRNA expression of alpha-synuclein, LC3-II and p53 decreased after SIAH1 knockdown. E1 protein and mRNA levels increased after SIAH1 siRNA.

  14. Results demonstrated that miR-107 directly down-regulated SIAH1 expression in human breast cancer cells. An inverse correlation between the expression of miR-107 and SIAH1 was found in human breast cancer tissues and cell lines.

  15. Similar to TAp73, DNp73 is stabilized by hypoxia in a HIF-1a-dependent manner, which otherwise is degraded by Siah1.

  16. findings demonstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of DR

  17. Data indicate that ubiquitin ligase Siah as a regulator of to Mesenchymal Transition (EMT) by controlling the abundance of the key transcription factor Zeb1, while Siah itself is subject to regulation by EMT-inducing factors.

  18. miRNA network regulates SIAH1 in in colorectal metastasis tissues.

  19. CDK2 up-regulates the protein level of KLF10 through reducing its association with SIAH1, a KLF10 E3-ubiqutin ligase involved in proteasomal degradation.

  20. molecular basis of Siah1 and Siah2 E3 ubiquitin ligase substrate specificity

Xenopus laevis E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) interaction partners

  1. two splicing forms, Siah1a and Siah1b, of the Xenopus seven in absentia homolog 1 gene (Siah1) were characterized.

SIAH1 Antigen Profile

Protein Summary

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Gene names and symbols associated with SIAH1

  • E3 ubiquitin-protein ligase Siah1 (Tsp_03055) antibody
  • E3 ubiquitin-protein ligase siah-1 (siah-1) antibody
  • siah E3 ubiquitin protein ligase 1 (Siah1) antibody
  • siah E3 ubiquitin protein ligase 1 (siah1) antibody
  • siah E3 ubiquitin protein ligase 1 (SIAH1) antibody
  • siah E3 ubiquitin protein ligase 1 L homeolog (siah1.L) antibody
  • id:ibd2635 antibody
  • siah antibody
  • Siah1 antibody
  • SIAH1A antibody
  • zgc:56026 antibody

Protein level used designations for SIAH1

E3 ubiquitin-protein ligase Siah1 , E3 ubiquitin-protein ligase SIAH1 , seven in absentia homolog 1 , siah-1 , siah-1a , seven in absentia 1A , seven in absentia-like protein 1

10900332 Trichinella spiralis
177138 Caenorhabditis elegans
140941 Rattus norvegicus
80955 Danio rerio
534655 Bos taurus
374076 Gallus gallus
6477 Homo sapiens
443864 Xenopus laevis
487293 Canis lupus familiaris
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