anti-E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) Antibodies

Human E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) interaction partners

1. Data suggest that lncRNA small nucleolar RNA host gene 1, as a pathogenic factor, promotes alpha-synuclein aggregation and toxicity by targeting the miR-15b-5p/seven in absentia homolog 1 axis.

2. Results show that abolishing ICP0:SIAH-1 interaction affects the HSV-2 phenotype during infection. In vitro, the SIAH-binding deficient mutant synthesized significantly less DNA and protein, and virus growth was clearly attenuated compared to wild-type virus. In model mice, HSV-2 carrying the SIAH-binding deficient mutation caused an acute infection in the murine eye and was able to spread to the innervating neurons.

3. Using the novel PUM1 and PUM2 mRNA target SIAH1 as a model, this study shows mechanistic differences between PUM1 and PUM2 and between NANOS1, 2, and 3 paralogues in the regulation of SIAH1.

4. Depletion of KDM3A coincided with the loss of SIAH1 induction and the accumulation of dimethylated H3K9 surrounding the SIAH1 promoter. Interestingly, KDM3A expression was also up-regulated by nutritional stress in a HIF-1alpha dependent manner.

5. The crystallographic models provide structural insights into the substrate binding of the SIAH family E3 ubiquitin ligases that are critically involved in regulating cancer-related pathways.

6. Results showed that SIAH1 and PTP4A1 expression was regulated by mir-944 in breast cancer cells. miR-944 binds directly the 3 UTR of their promotor region.

7. Study identified SIAH1/2 (SIAH) as the E3 ligase mediating Wnt-induced Axin degradation. SIAH proteins promote the ubiquitination and proteasomal degradation of Axin through interacting with a VxP motif in the GSK3-binding domain of Axin, and this function of SIAH is counteracted by GSK3 binding to Axin.

8. results suggest that CacyBP/SIP is involved in regulation of the Hsp90 chaperone machinery

9. PINK1 disease mutants failed to recruit synphilin-1 and did not activate mitophagy, indicating that PINK1-synphilin-1-SIAH-1 represents a new parkin-independent mitophagy pathway. Drugs that activate this pathway will provide a novel strategy to promote the clearance of damaged mitochondria in Parkinson's disease.

10. Results suggest that activated STAT3 regulates active beta-catenin protein levels via stabilization of SIAH-1 and the subsequent ubiquitin-dependent proteasomal degradation of beta-catenin in HEK293T cells.

11. Siah-1 expression was observed in 41.4% of oral squamous cell carcinoma. Siah-1 was expressed in the cytoplasm and cell membranes, and partially in the nucleus .

12. SIAH1 is associated with a tumor promoting role in breast cancer.

13. In neuroblastoma cells, siRNA silencing of SIAH1 promoted cellular proliferation and suppressed apoptosis. Protein and mRNA expression of alpha-synuclein, LC3-II and p53 decreased after SIAH1 knockdown. E1 protein and mRNA levels increased after SIAH1 siRNA.

14. Results demonstrated that miR-107 directly down-regulated SIAH1 expression in human breast cancer cells. An inverse correlation between the expression of miR-107 and SIAH1 was found in human breast cancer tissues and cell lines.

15. Similar to TAp73, DNp73 is stabilized by hypoxia in a HIF-1a-dependent manner, which otherwise is degraded by Siah1.

16. findings demonstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of DR

17. Data indicate that ubiquitin ligase Siah as a regulator of to Mesenchymal Transition (EMT) by controlling the abundance of the key transcription factor Zeb1, while Siah itself is subject to regulation by EMT-inducing factors.

18. miRNA network regulates SIAH1 in in colorectal metastasis tissues.

19. CDK2 up-regulates the protein level of KLF10 through reducing its association with SIAH1, a KLF10 E3-ubiqutin ligase involved in proteasomal degradation.

20. molecular basis of Siah1 and Siah2 E3 ubiquitin ligase substrate specificity

Xenopus laevis E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) interaction partners

1. two splicing forms, Siah1a and Siah1b, of the Xenopus seven in absentia homolog 1 gene (Siah1) were characterized.