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SIAH1 encodes a protein that is a member of the seven in absentia homolog (SIAH) family.
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Human Polyclonal SIAH1 Primary Antibody for IP, ELISA - ABIN268796
Guigon, Zhao, Lu, Willingham, Cheng: Regulation of beta-catenin by a novel nongenomic action of thyroid hormone beta receptor. in Molecular and cellular biology 2008
Show all 6 Pubmed References
Human Polyclonal SIAH1 Primary Antibody for ELISA, WB - ABIN184675
Susini, Passer, Amzallag-Elbaz, Juven-Gershon, Prieur, Privat, Tuynder, Gendron, Israël, Amson, Oren, Telerman: Siah-1 binds and regulates the function of Numb. in Proceedings of the National Academy of Sciences of the United States of America 2001
Show all 2 Pubmed References
Monoclonal SIAH1 Primary Antibody for IP, WB - ABIN534024
Schmidt, Park, Ahmed, Gundelach, Reed, Cheng, Knudsen, Tang: Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue. in Cancer research 2007
Human Polyclonal SIAH1 Primary Antibody for IHC, IHC (p) - ABIN4353439
Xiang, Gilkes, Hu, Takano, Luo, Lu, Bullen, Samanta, Liang, Semenza: Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. in Oncotarget 2015
Depletion of KDM3A (show KDM3A Antibodies) coincided with the loss of SIAH1 induction and the accumulation of dimethylated H3K9 surrounding the SIAH1 promoter. Interestingly, KDM3A (show KDM3A Antibodies) expression was also up-regulated by nutritional stress in a HIF-1alpha (show HIF1A Antibodies) dependent manner.
The crystallographic models provide structural insights into the substrate binding of the SIAH family E3 ubiquitin ligases that are critically involved in regulating cancer-related pathways.
Results showed that SIAH1 and PTP4A1 (show PTP4A1 Antibodies) expression was regulated by mir (show MLXIP Antibodies)-944 in breast cancer cells. miR (show MLXIP Antibodies)-944 binds directly the 3 UTR (show UTS2R Antibodies) of their promotor region.
Study identified SIAH1/2 (SIAH) as the E3 ligase mediating Wnt (show WNT2 Antibodies)-induced Axin (show AXIN1 Antibodies) degradation. SIAH proteins promote the ubiquitination and proteasomal degradation of Axin (show AXIN1 Antibodies) through interacting with a VxP motif in the GSK3-binding domain of Axin (show AXIN1 Antibodies), and this function of SIAH is counteracted by GSK3 binding to Axin (show AXIN1 Antibodies).
results suggest that CacyBP/SIP (show CACYBP Antibodies) is involved in regulation of the Hsp90 chaperone (show HSP90 Antibodies) machinery
PINK1 (show PINK1 Antibodies) disease mutants failed to recruit synphilin-1 (show SNCAIP Antibodies) and did not activate mitophagy, indicating that PINK1 (show PINK1 Antibodies)-synphilin-1 (show SNCAIP Antibodies)-SIAH-1 represents a new parkin (show PARK2 Antibodies)-independent mitophagy pathway. Drugs that activate this pathway will provide a novel strategy to promote the clearance of damaged mitochondria in Parkinson's disease.
Results suggest that activated STAT3 (show STAT3 Antibodies) regulates active beta-catenin (show CTNNB1 Antibodies) protein levels via stabilization of SIAH-1 and the subsequent ubiquitin-dependent proteasomal degradation of beta-catenin (show CTNNB1 Antibodies) in HEK293T cells.
Siah-1 expression was observed in 41.4% of oral squamous cell carcinoma. Siah-1 was expressed in the cytoplasm and cell membranes, and partially in the nucleus .
SIAH1 is associated with a tumor promoting role in breast cancer.
In neuroblastoma cells, siRNA silencing of SIAH1 promoted cellular proliferation and suppressed apoptosis. Protein and mRNA expression of alpha-synuclein, LC3-II and p53 decreased after SIAH1 knockdown. E1 protein and mRNA levels increased after SIAH1 siRNA.
two splicing forms, Siah1a and Siah1b, of the Xenopus seven in absentia homolog 1 gene (Siah1) were characterized.
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
E3 ubiquitin-protein ligase Siah1
, E3 ubiquitin-protein ligase SIAH1
, seven in absentia homolog 1
, seven in absentia 1A
, seven in absentia-like protein 1