anti-E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) Antibodies

SIAH1 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. Additionally we are shipping SIAH1 Proteins (9) and SIAH1 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIAH1 140941 Q920M9
SIAH1 6477 Q8IUQ4
SIAH1    
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Top anti-SIAH1 Antibodies at antibodies-online.com

Showing 10 out of 101 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, WB ABIN184675 staining (0.1µg/ml) of Human Liver lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Goat Un-conjugated IP, ELISA, WB Western Blot: SIAH1 Antibody [ABIN268796] - Analysis of Human Liver lysate (RIPA buffer, 35ug total protein per lane). Western Blot: SIAH1 Antibody [ABIN268796] - Analysis of Mouse (A, C) and Rat (B, D) Brain (A, B) and Liver (C, D) lysates (35ug protein in RIPA buffer). 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: SIAH1 Antibody [NBP2-20356] - Analysis of paraffin-embedded Lung Papillary Adenocarcinoma, using antibody at 1:250 dilution. Western Blot: SIAH1 Antibody [NBP2-20356] - A: U87-MG. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-SIAH1 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Jurkat cell lysate Researcher: Peter Brand & Dr. Oliver Kramer, Institute for Biochemistry and Biophysics, Center for Molecular Biomedicine, Friedrich-Schiller University JenaApplication: Western blottingSpecies+tissue/cell type: Human embryonic kidney 293T <br />How many ug’s of tissue/cell lysate run on the gel: 1:50 µg human HEK-293T cell lysate Primary Antibody dilution: 1:0000<br />Secondary Antibody: Anti-rabbit-IgG <br />Secondary Antibody Dilution: 1:0000 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from A549/HeLa cells, using SIAH1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Cow Goat Un-conjugated EIA, IP, WB   0.1 mg Log in to see 12 to 15 Days
$455.40
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of SIAH1 Antibody (Center) in human placenta tissue lysates (35ug/lane).This demonstrates the SIAH1 antibody detected the SIAH1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Bat Rabbit Un-conjugated IHC (p), WB Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μg Log in to see 7 to 9 Days
$639.83
Details
Bat Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details

SIAH1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SIAH1 Antibodies

  1. Human Polyclonal SIAH1 Primary Antibody for IP, ELISA - ABIN268796 : Guigon, Zhao, Lu, Willingham, Cheng: Regulation of beta-catenin by a novel nongenomic action of thyroid hormone beta receptor. in Molecular and cellular biology 2008 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal SIAH1 Primary Antibody for ELISA, WB - ABIN184675 : Susini, Passer, Amzallag-Elbaz, Juven-Gershon, Prieur, Privat, Tuynder, Gendron, Israël, Amson, Oren, Telerman: Siah-1 binds and regulates the function of Numb. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 2 Pubmed References

  3. Monoclonal SIAH1 Primary Antibody for IP, WB - ABIN534024 : Schmidt, Park, Ahmed, Gundelach, Reed, Cheng, Knudsen, Tang: Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue. in Cancer research 2007 (PubMed)

  4. Human Polyclonal SIAH1 Primary Antibody for IHC, IHC (p) - ABIN4353439 : Xiang, Gilkes, Hu, Takano, Luo, Lu, Bullen, Samanta, Liang, Semenza: Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. in Oncotarget 2015 (PubMed)

More Antibodies against SIAH1 Interaction Partners

Human E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) interaction partners

  1. Depletion of KDM3A (show KDM3A Antibodies) coincided with the loss of SIAH1 induction and the accumulation of dimethylated H3K9 surrounding the SIAH1 promoter. Interestingly, KDM3A (show KDM3A Antibodies) expression was also up-regulated by nutritional stress in a HIF-1alpha (show HIF1A Antibodies) dependent manner.

  2. The crystallographic models provide structural insights into the substrate binding of the SIAH family E3 ubiquitin ligases that are critically involved in regulating cancer-related pathways.

  3. Results showed that SIAH1 and PTP4A1 (show PTP4A1 Antibodies) expression was regulated by mir (show MLXIP Antibodies)-944 in breast cancer cells. miR (show MLXIP Antibodies)-944 binds directly the 3 UTR (show UTS2R Antibodies) of their promotor region.

  4. Study identified SIAH1/2 (SIAH) as the E3 ligase mediating Wnt (show WNT2 Antibodies)-induced Axin (show AXIN1 Antibodies) degradation. SIAH proteins promote the ubiquitination and proteasomal degradation of Axin (show AXIN1 Antibodies) through interacting with a VxP motif in the GSK3-binding domain of Axin (show AXIN1 Antibodies), and this function of SIAH is counteracted by GSK3 binding to Axin (show AXIN1 Antibodies).

  5. results suggest that CacyBP/SIP (show CACYBP Antibodies) is involved in regulation of the Hsp90 chaperone (show HSP90 Antibodies) machinery

  6. PINK1 (show PINK1 Antibodies) disease mutants failed to recruit synphilin-1 (show SNCAIP Antibodies) and did not activate mitophagy, indicating that PINK1 (show PINK1 Antibodies)-synphilin-1 (show SNCAIP Antibodies)-SIAH-1 represents a new parkin (show PARK2 Antibodies)-independent mitophagy pathway. Drugs that activate this pathway will provide a novel strategy to promote the clearance of damaged mitochondria in Parkinson's disease.

  7. Results suggest that activated STAT3 (show STAT3 Antibodies) regulates active beta-catenin (show CTNNB1 Antibodies) protein levels via stabilization of SIAH-1 and the subsequent ubiquitin-dependent proteasomal degradation of beta-catenin (show CTNNB1 Antibodies) in HEK293T cells.

  8. Siah-1 expression was observed in 41.4% of oral squamous cell carcinoma. Siah-1 was expressed in the cytoplasm and cell membranes, and partially in the nucleus .

  9. SIAH1 is associated with a tumor promoting role in breast cancer.

  10. In neuroblastoma cells, siRNA silencing of SIAH1 promoted cellular proliferation and suppressed apoptosis. Protein and mRNA expression of alpha-synuclein, LC3-II and p53 decreased after SIAH1 knockdown. E1 protein and mRNA levels increased after SIAH1 siRNA.

Xenopus laevis E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) interaction partners

  1. two splicing forms, Siah1a and Siah1b, of the Xenopus seven in absentia homolog 1 gene (Siah1) were characterized.

SIAH1 Antigen Profile

Protein Summary

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Gene names and symbols associated with SIAH1

  • E3 ubiquitin-protein ligase Siah1 (Tsp_03055) antibody
  • E3 ubiquitin-protein ligase siah-1 (siah-1) antibody
  • siah E3 ubiquitin protein ligase 1 (Siah1) antibody
  • siah E3 ubiquitin protein ligase 1 (siah1) antibody
  • siah E3 ubiquitin protein ligase 1 (SIAH1) antibody
  • siah E3 ubiquitin protein ligase 1 L homeolog (siah1.L) antibody
  • id:ibd2635 antibody
  • siah antibody
  • Siah1 antibody
  • SIAH1A antibody
  • zgc:56026 antibody

Protein level used designations for SIAH1

E3 ubiquitin-protein ligase Siah1 , E3 ubiquitin-protein ligase SIAH1 , seven in absentia homolog 1 , siah-1 , siah-1a , seven in absentia 1A , seven in absentia-like protein 1

GENE ID SPECIES
10900332 Trichinella spiralis
177138 Caenorhabditis elegans
140941 Rattus norvegicus
80955 Danio rerio
534655 Bos taurus
374076 Gallus gallus
6477 Homo sapiens
443864 Xenopus laevis
487293 Canis lupus familiaris
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