anti-Ewing Sarcoma Breakpoint Region 1 (EWSR1) Antibodies

EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. Additionally we are shipping EWSR1 Kits (5) and EWSR1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EWSR1 2130 Q01844
EWSR1 14030 Q61545
EWSR1 289752  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-EWSR1 Antibodies at antibodies-online.com

Showing 10 out of 156 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-EWSR1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate Lanes:   Lane 1: 50ug Hela Lysate  Primary Antibody Dilution:   1:1000  Secondary Antibody:   Anti-rabbit-HRP  Secondary Antibody Dilution:   1:10,000  Gene Name:   EWSR1  Submitted by:   Archa Fox, University of Western Australia  EWSR1 is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-EWSR1 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Jurkat cell lysate EWSR1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells WB Suggested Anti-EWSR1  Antibody Titration: 0.2-1 µg/mL  Positive Control: Jurkat cell lysate  EWSR1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-EWSR1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Jurkat cell lysate. EWSR1 is strongly supported by BioGPS gene expression data to be expressed in Jurkat Lanes:   Lane 1: 50ug Hela Lysate  Primary Antibody Dilution:   1:1000  Secondary Antibody:   Anti-rabbit-HRP  Secondary Antibody Dilution:   1:10,000  Gene Name:   EWSR1  Submitted by:   Archa Fox, University of Western Australia  EWSR1 is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells 100 μL 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB EB09167 (0.1µg/ml) staining of nuclear HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN335135 (0.3µg/ml) staining of nuclear HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- EWSR1 Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated IF, WB Western blot analysis of EWSR1 (arrow) using rabbit polyclonal EWSR1 Antibody (C-term) (ABIN658497). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the EWSR1 gene. 400 μL 10 to 11 Days
$385.00
Details
Cow Rabbit Un-conjugated WB Western blot analysis of EWS expression in HepG2 (A), Jurkat (B), HeLa (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Cow Goat Un-conjugated EIA, IHC (p), WB   0.1 mg 4 to 8 Days
$462.00
Details
Cow Rabbit Un-conjugated IHC, WB Host: Rabbit Target Name: EWSR1 Sample Type: 721_B Whole cell lysates Antibody Dilution: 1.0ug/ml  EWSR1 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells Rabbit Anti-EWSR1 Antibody Catalog Number: ARP32266_P050 Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Cytoplasmic, plasma membrane Primary Antibody Concentration: 1:100 Other Working Concentrations: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec 100 μL 2 to 3 Days
$289.00
Details
Bat Goat Un-conjugated ELISA, IHC, IHC (p), WB Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 to 14 Days
$484.00
Details

Top referenced anti-EWSR1 Antibodies

  1. Human Polyclonal EWSR1 Primary Antibody for IHC (p), IHC - ABIN449908 : Toretsky, Erkizan, Levenson, Abaan, Parvin, Cripe, Rice, Lee, Uren: Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. in Cancer research 2006 (PubMed)

  2. Human Polyclonal EWSR1 Primary Antibody for IP, WB - ABIN152319 : Sohn, Park, Kang, Wu: Accumulation of pre-let-7g and downregulation of mature let-7g with the depletion of EWS. in Biochemical and biophysical research communications 2012 (PubMed)

  3. Human Polyclonal EWSR1 Primary Antibody for ICC, IF - ABIN152318 : Davis, Kim, Ozsolak, Widlund, Rozenblatt-Rosen, Granter, Du, Fletcher, Denny, Lessnick, Linehan, Kung, Fisher: Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. in Cancer cell 2006 (PubMed)

More Antibodies against EWSR1 Interaction Partners

Human Ewing Sarcoma Breakpoint Region 1 (EWSR1) interaction partners

  1. EWSR1 fusion with CREM has only been observed in 3 intracranial myxoid tumors

  2. FUS, EWSR1, TAF15 and MATR3 within the RNAP II/U1 snRNP machinery play distinct roles in the development of amyotrophic lateral sclerosis and spinal muscular atrophy that are more intimately tied to one another than previously thought.

  3. A high quality EWS-RNA interactome uncovered its specific and prevalent interaction with a large subset of primary microRNAs. Knockdown of EWS reduced, whereas overexpression enhanced, expression of its target miRNAs. While repressing Drosha expression, as reported earlier, EWS was also able to enhance the recruitment of Drosha to chromatin. EWS may positively and negatively regulate miRNA biogenesis in distinct ways.

  4. REVIEW: summarizes the growing list of mesenchymal neoplasms that are associated with EWSR1 gene rearrangements

  5. URCS with EWSR1-NFATc2 fusion share a distinct DNA methylation signature and carry characteristic copy number alterations, which emphasizes that these sarcomas should be considered separately from EwS.

  6. Case Report: renal cell carcinoma with EWSR1-TFE3 fusion.

  7. Report a group of locally recurrent superficial acral tumors, characterized by bland spindle cell fascicular growth, occasional zonation pattern, ERG positivity, and recurrent EWSR1-SMAD3 gene fusions.

  8. EWSR1 rearrangement was detected without definitive partner genes should be considered for the presence of cAMP response element modulator rearrangement

  9. ATG4B expression was observed markedly upregulated by EWS-FLI1 overexpression, and silencing of ATG4B dramatically inhibits autophagy in Ewing sarcoma cells.

  10. Studies demonstrate that the translocation-derived fusion protein EF (EWS-FLI1) misregulates numerous genes involved in metabolism suggesting that EF is a master regulator of metabolic reprogramming in Ewing sarcoma, diverting metabolites toward biosynthesis.

  11. Together, the data demonstrate the critical requirement of GGAA-microsatellites as EWS/FLI activating response elements in vivo and reveal an unexpected role for the EWS portion of the EWS/FLI fusion in binding to sweet-spot GGAA-microsatellites.

  12. EWSR1 fusion protein is required for PAX7 expression in Ewing sarcoma and identify a candidate EWSR1-FLI1-bound PAX7 enhancer that coincides with both a consensus GGAA repeat-containing binding site and a peak of regulatory H3K27 acetylation.

  13. In the 3 cases of the primary extraskeletal myxoid chondrosarcoma (EMC) of bone we found the most frequent and specific chromosomal translocation t(9:22) EWSR1-NR4A3 of the extraskeletal counterpart.

  14. a breakpoint in the EWSR1-ATF1 fusion to be the same as that reported in HCCC. Established CCOC-T cells grew extremely slowly, but the cells showed highly invasive activity

  15. study proposed that EWSR1 rearrangement was present in a subset of myoepithelial tumors of salivary glands, with variable morphological features

  16. EWSR1 Gene Rearrangement is associated with Endometrial Primitive Neuroectodermal Tumor.

  17. -cell lymphoblastic leukemia with t(11;22)(q24;q12) and EWSR1 rearrangement.

  18. Kinetics of EWSR1 fusion sequence copy numbers in the plasma are correlated with changes of the tumor volume in patients with localized and metastatic disease.

  19. Authors found that FUS, EWS and TAF15 expression is differentially regulated during brain development, both in time and in space. In particular, this study identifies a fine-tuned regulation of FUS and EWS during neuronal differentiation.

  20. Recent advances in biologic and genomic understanding of these two cancers has expanded the potential for therapeutic advancement and prevention. In Ewing sarcoma, directed focus on inhibition of EWSR1-FLI1 and its effectors has produced promising results.

Mouse (Murine) Ewing Sarcoma Breakpoint Region 1 (EWSR1) interaction partners

  1. the Fox transcription factor binding motif was frequently observed within EWS-FLI1 peaks and Foxq1 was identified as the cooperative partner that interacts with the EWS portion of EWS-FLI1.

  2. Authors found that FUS, EWS and TAF15 expression is differentially regulated during brain development, both in time and in space. In particular, this study identifies a fine-tuned regulation of FUS and EWS during neuronal differentiation.

  3. Gnai1 function is impaired in the spinal cord of Ews/Ewsr1 KO mice

  4. EWS is normally O-GlcNAc glycosylated in the brain.

  5. glycosylation of EWS protein

  6. EWSR1 is involved in the post-transcriptional regulation of Uvrag via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.

  7. EWS is essential during the early steps of white adipocyte differentiation, at least in part through its regulation of BMP2 and BMP4 expression.

  8. EWS has a role in mitochondrial and cellular energy homeostasis that involves controlling PGC-1alpha protein stability

  9. both Etv1 and Ewsr1 were necessary for Fgf10 expression and elongation of the limb bud.

  10. EWS is involved in post-transcriptional regulation of Col4a1 and CTGF via a Drosha-miRNA-dependent pathway.

  11. These results demonstrate that EWS is essential for early brown fat lineage determination.

  12. Forced expression of EWS/ATF1 resulted in the development of EWS/ATF1-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1-driven transformation.

  13. these findings suggest that EWS mediates generation of mature let-7g from pre-let-7g.

  14. EWS is likely to play a significant role in maintaining the functional capacity of stem cells.

  15. Findings suggest that EWS/FLI1 induces apoptosis, at least partially, through the activation of CASP3.

  16. EWS has a role in mesodermal cell differentiation

  17. Oct-4-mediated transactivation is stimulated by EWS

  18. EWS/FLI1 has a role in regulating tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins TSP1 and TSP2

  19. GLI1 appears to be a transcriptionally deregulated target of EWS/FLI1 that mediates a portion of its tumorigenic phenotype.

  20. EWS contributes to start site recognition in TATA-less mammalian promoters.

Zebrafish Ewing Sarcoma Breakpoint Region 1 (EWSR1) interaction partners

  1. Mutation of the EWS gene modulates Sox9 gene expression essential for chondrocyte differentiation.

  2. Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development

  3. Interaction between EWSR1/FLI1 and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.

EWSR1 Antigen Profile

Protein Summary

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

Gene names and symbols associated with EWSR1

  • EWS RNA binding protein 1 (EWSR1) antibody
  • Ewing sarcoma breakpoint region 1 (Ewsr1) antibody
  • EWS RNA-binding protein 1 (Ewsr1) antibody
  • EWS RNA-binding protein 1a (ewsr1a) antibody
  • EWS RNA binding protein 1 (ewsr1) antibody
  • EWS RNA binding protein 1 (Ewsr1) antibody
  • EWS RNA binding protein 1 L homeolog (ewsr1.L) antibody
  • EWS RNA-binding protein 1b (ewsr1b) antibody
  • AU018891 antibody
  • bK984G1.4 antibody
  • DKFZp459K1116 antibody
  • Ews antibody
  • Ewsh antibody
  • ewsr1 antibody
  • ewsr1.S antibody
  • fb40b11 antibody
  • fc04c01 antibody
  • fusl antibody
  • wu:fb40b11 antibody
  • wu:fb75g09 antibody
  • wu:fc04c01 antibody
  • zgc:55864 antibody

Protein level used designations for EWSR1

Ewing sarcoma breakpoint region 1 , Ewings sarcoma EWS-Fli1 (type 1) oncogene , RNA-binding protein EWS , Ewing sarcoma homolog , Ewing sarcoma RNA-binding protein , EWS RNA binding protein 1 S homeolog , uncharacterized protein LOC734969 , Ewing sarcoma breakpoint region 1b , fusion, derived from t(12;16) malignant liposarcoma, like

GENE ID SPECIES
2130 Homo sapiens
14030 Mus musculus
289752 Rattus norvegicus
323597 Danio rerio
748264 Pan troglodytes
100034010 Equus caballus
100156911 Sus scrofa
417022 Gallus gallus
534073 Bos taurus
609786 Canis lupus familiaris
100018014 Monodelphis domestica
100173925 Pongo abelii
100550662 Meleagris gallopavo
100557388 Anolis carolinensis
100595788 Nomascus leucogenys
100718262 Cavia porcellus
734969 Xenopus laevis
322880 Danio rerio
Selected quality suppliers for anti-EWSR1 (EWSR1) Antibodies
Did you look for something else?