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EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. Additionally we are shipping EWSR1 Kits (5) and EWSR1 Proteins (4) and many more products for this protein.
Showing 10 out of 160 products:
Human Polyclonal EWSR1 Primary Antibody for ICC, IF - ABIN152318
Davis, Kim, Ozsolak, Widlund, Rozenblatt-Rosen, Granter, Du, Fletcher, Denny, Lessnick, Linehan, Kung, Fisher: Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. in Cancer cell 2006
Human Polyclonal EWSR1 Primary Antibody for IHC (p), IHC - ABIN449908
Toretsky, Erkizan, Levenson, Abaan, Parvin, Cripe, Rice, Lee, Uren: Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. in Cancer research 2006
Human Polyclonal EWSR1 Primary Antibody for IP, WB - ABIN152319
Sohn, Park, Kang, Wu: Accumulation of pre-let-7g and downregulation of mature let-7g with the depletion of EWS. in Biochemical and biophysical research communications 2012
ATG4B (show ATG4B Antibodies) expression was observed markedly upregulated by EWS-FLI1 (show FLI1 Antibodies) overexpression, and silencing of ATG4B (show ATG4B Antibodies) dramatically inhibits autophagy in Ewing sarcoma cells.
Studies demonstrate that the translocation-derived fusion protein EF (EWS-FLI1 (show FLI1 Antibodies)) misregulates numerous genes involved in metabolism suggesting that EF is a master regulator of metabolic reprogramming in Ewing sarcoma, diverting metabolites toward biosynthesis.
Together, the data demonstrate the critical requirement of GGAA-microsatellites as EWS/FLI (show FLII Antibodies) activating response elements in vivo and reveal an unexpected role for the EWS portion of the EWS/FLI (show FLII Antibodies) fusion in binding to sweet-spot GGAA-microsatellites.
EWSR1 fusion protein is required for PAX7 (show PAX7 Antibodies) expression in Ewing sarcoma and identify a candidate EWSR1-FLI1 (show FLI1 Antibodies)-bound PAX7 (show PAX7 Antibodies) enhancer that coincides with both a consensus GGAA repeat-containing binding site and a peak of regulatory H3K27 acetylation.
In the 3 cases of the primary extraskeletal myxoid chondrosarcoma (EMC) of bone we found the most frequent and specific chromosomal translocation t(9:22) EWSR1-NR4A3 (show NR4A3 Antibodies) of the extraskeletal counterpart.
a breakpoint in the EWSR1-ATF1 (show AFT1 Antibodies) fusion to be the same as that reported in HCCC. Established CCOC-T cells grew extremely slowly, but the cells showed highly invasive activity
study proposed that EWSR1 rearrangement was present in a subset of myoepithelial tumors of salivary glands, with variable morphological features
EWSR1 Gene Rearrangement is associated with Endometrial Primitive Neuroectodermal Tumor.
-cell lymphoblastic leukemia with t(11;22)(q24;q12) and EWSR1 rearrangement.
Kinetics of EWSR1 fusion sequence copy numbers in the plasma are correlated with changes of the tumor volume in patients with localized and metastatic disease.
the Fox transcription factor binding motif was frequently observed within EWS-FLI1 (show FLI1 Antibodies) peaks and Foxq1 (show FOXQ1 Antibodies) was identified as the cooperative partner that interacts with the EWS portion of EWS-FLI1 (show FLI1 Antibodies).
Authors found that FUS (show FUS Antibodies), EWS and TAF15 (show TAF15 Antibodies) expression is differentially regulated during brain development, both in time and in space. In particular, this study identifies a fine-tuned regulation of FUS (show FUS Antibodies) and EWS during neuronal differentiation.
Gnai1 (show GNAI1 Antibodies) function is impaired in the spinal cord of Ews/Ewsr1 KO mice
EWS is normally O-GlcNAc glycosylated in the brain.
glycosylation of EWS protein
EWSR1 is involved in the post-transcriptional regulation of Uvrag (show UVRAG Antibodies) via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.
EWS is essential during the early steps of white adipocyte differentiation, at least in part through its regulation of BMP2 (show BMP2 Antibodies) and BMP4 (show BMP4 Antibodies) expression.
EWS has a role in mitochondrial and cellular energy homeostasis that involves controlling PGC-1alpha protein stability
both Etv1 (show ETV1 Antibodies) and Ewsr1 were necessary for Fgf10 (show FGF10 Antibodies) expression and elongation of the limb bud.
EWS is involved in post-transcriptional regulation of Col4a1 (show COL4A1 Antibodies) and CTGF (show CTGF Antibodies) via a Drosha (show DROSHA Antibodies)-miRNA-dependent pathway.
Mutation of the EWS gene modulates Sox9 (show SOX9 Antibodies) gene expression essential for chondrocyte differentiation.
Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development
Interaction between EWSR1/FLI1 (show FLI1 Antibodies) and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
Ewing sarcoma breakpoint region 1
, Ewings sarcoma EWS-Fli1 (type 1) oncogene
, RNA-binding protein EWS
, Ewing sarcoma homolog
, Ewing sarcoma RNA-binding protein
, EWS RNA binding protein 1 S homeolog
, uncharacterized protein LOC734969
, Ewing sarcoma breakpoint region 1b
, fusion, derived from t(12;16) malignant liposarcoma, like